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[ CAS No. 52927-98-7 ]

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Chemical Structure| 52927-98-7
Chemical Structure| 52927-98-7
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Product Details of [ 52927-98-7 ]

CAS No. :52927-98-7 MDL No. :MFCD22376643
Formula : C8H7Br2Cl Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :298.40 g/mol Pubchem ID :21828491
Synonyms :

Safety of [ 52927-98-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 52927-98-7 ]

  • Downstream synthetic route of [ 52927-98-7 ]

[ 52927-98-7 ] Synthesis Path-Downstream   1~7

  • 1
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  • [ 52927-98-7 ]
YieldReaction ConditionsOperation in experiment
77% With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20.0℃; for 2.0h; Step 1: 2-Bromo-l-(2-bromoethyl)-4-chlorobenzene [00342] 2-(2-bromo-4-chlorophenyl)ethanol ( 1.97 g, 8.36 mmol) and carbon tetrabromide (3.61 g, 10.9 mmol) were dissolved into DCM (30.0 mL, 468 mmol), then triphenylphosphine (3.29 g, 12.5 mmol) was added at rt. The reaction was stirred at rt for 2 hrs. To the reaction mixture was added 100 mL hexane with stirring, at which point a precipitate formed that was removed by filtration. The filtrate was concentrated and purified by flash column (80g column, 100% hexane as eluent) to provide 1.92g (77%) of the title compound. NMR (400 MHz, Chloroform-d) delta 7.55 - 7.41 (s, 1 H), 7.23 - 7.15 (d, J = 8.2 Hz, 1 H), 7.13 (d, J = 8.2 Hz, 1 H), 3.49 (t, J = 7.3 Hz, 2H), 3.18 (t, J = 7.3 Hz, 2H).
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  • 6
  • [ 52864-55-8 ]
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  • [ 6258-60-2 ]
  • 2-bromo-4-chloro-1-{2-[(4-methoxybenzyl)sulfanyl]ethyl}benzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With potassium carbonate; In dimethyl sulfoxide; at 20.0℃; for 72.0h; Step 2: 2-Bromo-4-chloro-l-{2-[(4-methoxybenzyl)sulfanyl]ethyl}benzene4-([2-(2-bromo-4- chlorophenyl)ethyl]sulfanyl}methyl)phenyl methyl ether [00343] To a solution of 2-biOmo- l -(2-bromoethyl)-4-chlorobenzene (2.47 g, 8.28 mmol) and p- methoxy-a-toluenethiol ( 1.3262 mL, 9.5190 mmol) in dimethyl sulfoxide (6.00 mL, 84.5 mmol) was added potassium carbonate (2.2880 g, 16.555 mmol) and the reaction was stirred at rt for 72 h. The reaction was quenched by pouring into 40ml water, the layers were separated, and the aqueous layer was extracted 2 x 15ml DCM. The combined organic layers were concentrated and purified by flash column (80g, eluent 0- 15% EtOAc in hexane for 15 min) to give 1.95g (64%) of title compound. NMR (400 MHz, Chloroform-d) delta 7.48 (s, 1 H), 7.23 - 7.13 (m, 3H), 7.06 (d, J = 8.2 Hz, 1 H), 6.80 (d, J = 8.5 Hz, 2H), 3.75 (s, 3H), 3.64 (s, 2H), 2.93 - 2.79 (t, J = 7.3 Hz, 2H), 2.65 - 2.51 (t, J = 7.3 Hz, 2H).
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