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Chemical Structure| 52916-82-2 Chemical Structure| 52916-82-2

Structure of 52916-82-2

Chemical Structure| 52916-82-2

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Product Details of [ 52916-82-2 ]

CAS No. :52916-82-2
Formula : C11H13NO3
M.W : 207.23
SMILES Code : CN(C)C(=O)OC1=CC=C(C=C1)C(C)=O
MDL No. :MFCD03028776

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Application In Synthesis of [ 52916-82-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52916-82-2 ]

[ 52916-82-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 383-62-0 ]
  • [ 52916-82-2 ]
  • 4-[4-chloro-4,4-difluoro-3-hydroxybut-2-enoyl]phenyl dimethylcarbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Sodium hydride (1 16 mg, 2.9 mmol, 60% in mineral oil) was added to a suspension of 4-acetylphenyl dimethylcarbamate (300 mg, 1.4 mmol) in Tetrahydrofuran (3.0 ml_) at 0C. The reaction mixture was stirred at 0C for 30 min and <strong>[383-62-0]ethyl 2-chloro-2,2-difluoroacetate</strong> (344 mg, 2.2 mmol) was then added. The reaction mixture was stirred for 3h at rt. Water was then added and the organic solvent was concentrated under reduced pressure. Aqueous hydrochloric acid solution (1 M) was then added until pH 1. The aqueous layer was extracted with EtOAc, the combined organic layers were dried (MgSC), filtered and concentrated under reduced pressure to give 4-[4-chloro-4,4-difluoro-3-hydroxybut-2- enoyl]phenyl dimethylcarbamate as a yellow oil (449 mg, 20% yield, 20% purity) which was used in the next step without further purification. MS (ESI): 320 ([M+H]+)
 

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