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[ CAS No. 530081-57-3 ]

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Chemical Structure| 530081-57-3
Chemical Structure| 530081-57-3
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CAS No. :530081-57-3 MDL No. :MFCD07363814
Formula : C9H10BrNO2S Boiling Point : 369.6°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :276.15 g/mol Pubchem ID :-
Synonyms :

Safety of [ 530081-57-3 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 UN#:
Hazard Statements:H302-H312-H332 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 530081-57-3 ]

  • Downstream synthetic route of [ 530081-57-3 ]

[ 530081-57-3 ] Synthesis Path-Downstream   1~13

  • 1
  • [ 530081-57-3 ]
  • [ 73183-34-3 ]
  • C15H22BNO4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With anhydrous potassium acetate In 1,4-dioxane at 110℃; for 16h; B.6 378 mg of 1-(4-bromo-benzenesulfonyl)-azetidine (compound C3) are dissolved in 10 ml of oxygen- free dioxane under an atmosphere of dry nitrogen. Subsequently, 383 mg of bis(pinacolato)diboron, 30 mg of Pd(CI)2(dppf) ' CH2CI2, 23 mg of DPPF (1 ,1'-bis(diphenylphosphino)-ferrocene), and 403 mg of potassium acetate are added. The reaction mixture is heated at 1100C for 16 hours during which time the former yellowish suspension becomes black (LC-MS monitoring for boronic ester intermediate). Thereafter, 300 mg of 7-[2-(6-bromo-3/-/-imidazo[4,5-b]pyridin-2-yl)-ethyl]-azepan-2-one (compound C1), 2.70 ml of aqueous sodium carbonate solution (strength 2.0 M), and 66 mg of frans-dichloro- bis(tricyclohexyl-phosphine)-palladium(ll) are added and the reaction mixture is heated at 1100C for 72 hours. Subsequently, the mixture is diluted with 50 ml of water and extracted three times each with 100 ml of dichloromethane. The organic layer is separated, dried using Na2SO4 (solid) and concentrated in vacuo. The resulting crude material is purified by chromatography on flash silica gel (eluent gradient: dichloromethane / 0-10 vol.% ethanol) to yield 187 mg of the title compound as an oil. ESI-MS: 454.2 (MH+). TLC: Rf = 0.29 (dichloromethane/ethanol 10:1 parts by volume)
With palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous potassium acetate In 1,4-dioxane at 20 - 120℃; for 18h; Inert atmosphere; 10 Synthesis of Compound 10-2 Compound 10-1 (5.00 g, 17.9 mmol) was dissolved in dioxane (100 mL) at room temperature under nitrogen protection, followed by the addition of bis(pinacolato)diboron (5.01g, 19.73mmol), potassium acetate (5.28g, 53.80mmol) and [1,1'-bis(diphenylphosphino)ferrocene]dichloride Palladium dichloromethane complex (0.73 g, 0.90 mmol), the reaction mixture was heated to 70°C and stirred for 2 hours, then heated to 120°C and stirred for 16 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, poured into water (100 mL), and extracted with ethyl acetate (100 mL×3). The organic phases were combined, washed with saturated brine (200 mL), and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The obtained residue was separated by column chromatography (petroleum ether/ethyl acetate, volume ratio: V/V=1/1) to obtain compound 10-2.
  • 2
  • [ 503-29-7 ]
  • [ 98-58-8 ]
  • [ 530081-57-3 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In dichloromethane; water at 20℃; for 17h; C.3 4.09 g of azetidine are dissolved in a two-phase solvent system of 200 ml of dichloromethane and 130 ml of an aqueous potassium carbonate solution (strength 4.0 M). Subsequently, a solution of 15.25 g of commercially available 4-bromo-benzenesulfonyl chloride in 70 ml of dichloromethane is slowly added to the reaction mixture. Thereafter, the mixture is vigorously stirred for 17 hours at room temperature. For extraction, 200 ml of dichloromethane and 100 ml of water are added. The organic layer is dried using Na2SO4, filtered with suction, and concentrated in vacuo to yield 15.22 g of the title compound as a colorless, amorphous solid of m.p. 145°C. ESI-MS: 276.1/278.0 (MH+, 100%:95%). TLC: Rf = 0.59 (dichloromethane/ ethanol 10:1 parts by volume)
In dichloromethane at 15 - 25℃; Inert atmosphere; 1-((4-bromophenyl)sulfonyl)azetidine General procedure: To the solution of 4-bromobenzene-l-sulfonyl chloride (507 mg, 1.98 mmol) in DCM (6.0 mL), was added azetidine (280 mg, 4.90 mmol) and the reaction mixture was stirred at room tempearture under nitrogen overnight. The reaction was then quenched by addition of saturated aqueous NH4C1 and the reaction mixture was extracted with DCM (x 3). The organic layers were washed with water, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica chromatography, eluting with 0-60% EtOAc in hexanes to afford 1-24-1 as a solid. LRMS (ESI) calc'd for C9HnBrN02S [M+H]+: 278, found 278. 1H NMR (600 MHz, CDC13): δ 7.73 (d, 2H, / = 8.6 Hz), 7.70 (d, 2H, / = 8.6 Hz), 3.79 (t, 4H, / = 7.4 Hz), 2.11 (pentet, 2H, / = 7.9 Hz).
YieldReaction ConditionsOperation in experiment
93%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; 4-bromo-N-isopro ylbenzenesulfonamide General procedure: To a solution of propan-2-amine (160 mg, 2.6 mmol) and DIPEA (780 mg, 6.0 mmol) in CH2CI2 (7 mL) was added a solution of 4-bromobenzene-l-sulfonyl chloride (510 mg, 2.0 mmol) in CH2CI2 (14 mL). The resulting reaction mixture was stirred at rt overnight, then was poured into water (20 mL), and extracted with CH2CI2 (3 x 15 ml). The combined organic layers were concentrated in vacuo to afford a residue that was purified by column chromatography on silica (pet ether/EtOAc: 20/1) to give 4-bromo-N- isopropylbenzenesulfonamide. 1H NMR (400 MHz, CDC13): δ 7.75 - 7.72 (m, 2 H), 7.65 - 7.62 (m, 2 H), 4.43 (d, / = 7.52 Hz, 1 H), 3.49 - 3.44 (m, 1 H), 1.08 (d, / = 6.4 Hz, 6 H).
  • 4
  • [ 530081-57-3 ]
  • [ 934758-28-8 ]
  • 6-[4-(azetidine-1-sulfonyl)-phenyl]-2-[2-(4-methoxy-pyridin-2-yl)-vinyl]-oxazolo[4,5-b]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: 1-((4-bromophenyl)sulfonyl)azetidine With potassium acetate; bis(pinacol)diborane In 1,4-dioxane at 160℃; for 0.666667h; Microwave irradiation; Stage #2: 6-bromo-2-[2-(4-methoxy-pyridin-2-yl)-vinyl]-oxazolo[4,5-b]pyridine With sodium carbonate In 1,4-dioxane; water at 140℃; for 0.333333h; Microwave irradiation; A6 Example A6; 6-[4-(Azetidine-1-sulfonyl)-phenyl]-2-[2-(4-methoxy-pyridin-2-yl)-vinyl]-oxazolo[4,5- b]pyridine; A stirred mixture of 0.14 g (0.50 mmol) 1-(4-bromo-benzenesulfonyl)-azetidine, 0.14 g (0.55 mmol) bis(pinacolato)-diboron, 8.3 mg (0.015 mmol) 1 ,1'-bis(diphenylphosphino)ferrocene (dppf), 11 mg (0.015 mmol) PdCI2(dppf)xCH2CI2 and 0.15 g (1.50 mmol) potassium acetate in 3 ml absolute dioxane is heated to 16O0C for 40 min with a microwave equipment. After cooling to room temperature 0.11 g (0.33 mmol) 6-bromo-2-[2-(4-methoxy-pyridin-2-yl)-vinyl]-oxazolo[4,5-b]pyridine (starting compound A2), 15.0 mg (0.02 mmol) PdCI2(PcHeX)3 and 1 ml of a 2 N aqueous Na2CO3 solution are added to the EPO reaction mixture. The suspension is heated again with a microwave equipment to 14O0C for 20 min. For workup, the mixture is poured into 100 ml water and then extracted three times with CH2CI2- The combined organic phases are dried over MgSO4, filtered and concentrated in vacuo. Subsequent purification by silica gel chromatography [CH2CI2/CH3OH (98/2 parts by volume)] affords the title compound (0.34 g) as yellow crystals. The mass spectrum shows the molecular peak MH+ at 449.2 Da.
  • 5
  • [ 530081-57-3 ]
  • [ 1259614-15-7 ]
  • methyl 3-(4-(azetidin-1-ylsulfonyl)phenoxy)-5-((1-methoxypropan-2-yl)oxy)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate In N,N-dimethyl-formamide at 120℃; for 3h; Microwave irradiation; Inert atmosphere; Step 2: Synthesis of Methyl Benzoates 26a-j General procedure: N,N-dimethylformamide (5 mL) was added to the mixture of 25 (5.0 mmol, 1.0 equiv.), 4-bromophenyl derivatives (6.0 mmol, 1.2 equiv.), cesium carbonate (10.0 mmol, 2.0 equiv.), copper(I) iodide (2 mmol, 0.4 equiv.) and 2,2,6,6-tetramethyl-3,5-heptanedione (4.0 mmol, 0.8 equiv), and the mixture was stirred in a microwave reactor under argon for 3 h at 120 °C. After the reaction vials were cooled to room temperature and filtered over celite the filtrate was washed with saturated aqueous ammonium chloride and brine successively, dried over anhydrous sodium sulfate, and concentrated in vacuum. The resulting residue was purified by silica gel chromatography (ethyl acetate/petroleum ether, v/v, 25:75 to 50:50) to afford methyl benzoate 26a-j.
  • 6
  • azetidine hydrochloride [ No CAS ]
  • [ 98-58-8 ]
  • [ 530081-57-3 ]
YieldReaction ConditionsOperation in experiment
88.7% With triethylamine In tetrahydrofuran; water A91.5 Step-5. Synthesis of l-(4-bromobenzenesulfonyl)azetidine (A91.10) A solution of 4-bromobenzene-l-sulfonyl chloride (A91.8) (10 g, 39.1 mmol) in tetahydrofuran (200 mL) was added dropwise to a solution of azetidine hydrochloride (A91.9) (7.31 g, 7.31 g) and triethylamine (15.7 g, 156 mmol, 21.6 mL) in water (100 mL) at 0 OC. The solution was stirred for 12 hours at room temperature and evaporated. The resulting mass was suspended in water (200 mL) and extracted with ethyl acetate (200 mL). The organic layer was washed with water (200 mL), 5% aq solution of hydrochloric acid (200 mL), brine (200 mL), dried over sodium sulfate and evaporated under reduced pressure to afford l-(4- bromobenzenesulfonyl)azetidine as white powder (A91.10) (10 g, 36.2 mmol, 95% purity, 88.7% yield).
  • 7
  • [ 530081-57-3 ]
  • lithium-4-(azetidine-1-sulfonyl)benzene-1-sulfinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: 1-((4-bromophenyl)sulfonyl)azetidine With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Stage #2: With sulfur dioxide In tetrahydrofuran at -78℃; A91.6 Step-6. Synthesis oflithium-4-(azetidine-l-sulfonyl)benzene-l-sulfinate (A91.il) 2.5M solution of n-butyllithium (2.54 g, 39.8 mmol, 15.9 mL) in hexane was added dropwise for 30 min to a solution of l-(4-bromobenzenesulfonyl)azetidine (A91.10) (10 g, 36.2 mmol) in tetrahydrofuran (250 mL) maintained under nitrogen atmosphere at -78°C. The resulting solution was stirred at -78 °C for 2 h. Sulfur dioxide (23 g, 362 mmol) solution in tetrahydrofuran (200 mL) was added to the solution at -78 °C for 30 sec. After, ether (200 mL) was added and the precipitate was collected by filtration. The solid was washed with ether (100 mL x 2) and dried in vacuum to give lithium-4-(azetidine-l-sulfonyl)benzene-l-sulfmate as a white solid (A91.i l) (9 g, 33.6 mmol, 90% purity, 83.7% yield).
  • 8
  • [ 530081-57-3 ]
  • 4-(azetidine-1-sulfonyl)benzene-1-sulfonyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere 1.2: -78 °C 2.1: sulfuryl dichloride / dichloromethane
  • 9
  • [ 530081-57-3 ]
  • 4-(azetidine-1-sulfonyl)-N-[2-(4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}piperidin-1-yl)-3-fluorophenyl]benzene-1-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere 1.2: -78 °C 2.1: sulfuryl dichloride / dichloromethane 3.1: pyridine / acetonitrile / 24 h / 20 °C
  • 10
  • [ 530081-57-3 ]
  • C29H35FN4O6S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous potassium acetate / 1,4-dioxane / 18 h / 20 - 120 °C / Inert atmosphere 2: anhydrous sodium carbonate; methanesulfonato (2-di-tert-butylphosphino-3,4,5,6-tetramethyl-2’,4’,6’-triisopropyl-1,1-biphenyl)(2’-amino-1,1‘-biphenyl-2-yl) palladium(II) / N,N-dimethyl-formamide / 12 h / 20 - 65 °C / Inert atmosphere
  • 11
  • [ 530081-57-3 ]
  • (S)-N-((S)-2-(4'-(azetidin-1-ylsulfonyl)-3-fluoro-[1,1'-biphenyl]-4-yl)-1-cyanoethyl)-1,4-oxazepane-2-carboxamide formic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous potassium acetate / 1,4-dioxane / 18 h / 20 - 120 °C / Inert atmosphere 2: anhydrous sodium carbonate; methanesulfonato (2-di-tert-butylphosphino-3,4,5,6-tetramethyl-2’,4’,6’-triisopropyl-1,1-biphenyl)(2’-amino-1,1‘-biphenyl-2-yl) palladium(II) / N,N-dimethyl-formamide / 12 h / 20 - 65 °C / Inert atmosphere 3: 0.33 h / 50 °C
  • 12
  • [ 530081-57-3 ]
  • C29H34F2N4O6S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous potassium acetate / 1,4-dioxane / 18 h / 20 - 120 °C / Inert atmosphere 2: anhydrous sodium carbonate; methanesulfonato (2-di-tert-butylphosphino-3,4,5,6-tetramethyl-2’,4’,6’-triisopropyl-1,1-biphenyl)(2’-amino-1,1‘-biphenyl-2-yl) palladium(II) / N,N-dimethyl-formamide / 3 h / 20 - 60 °C / Inert atmosphere
  • 13
  • [ 530081-57-3 ]
  • (S)-N-((S)-2-(4'-(azetidin-1-ylsulfonyl)-2,5-difluoro-[1,1'-biphenyl]-4-yl)-1-cyanoethyl)-1,4-oxazepane-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous potassium acetate / 1,4-dioxane / 18 h / 20 - 120 °C / Inert atmosphere 2: anhydrous sodium carbonate; methanesulfonato (2-di-tert-butylphosphino-3,4,5,6-tetramethyl-2’,4’,6’-triisopropyl-1,1-biphenyl)(2’-amino-1,1‘-biphenyl-2-yl) palladium(II) / N,N-dimethyl-formamide / 3 h / 20 - 60 °C / Inert atmosphere 3: sulfuric acid / 1,4-dioxane / 0.33 h / 20 - 50 °C
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