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Chemical Structure| 5316-76-7 Chemical Structure| 5316-76-7

Structure of 5316-76-7

Chemical Structure| 5316-76-7

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Product Details of [ 5316-76-7 ]

CAS No. :5316-76-7
Formula : C4H5ClN2S
M.W : 148.61
SMILES Code : CC1=C(Cl)SC(N)=N1
MDL No. :MFCD10699130

Safety of [ 5316-76-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H318
Precautionary Statements:P280-P305+P351+P338
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 5316-76-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5316-76-7 ]

[ 5316-76-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6142-15-0 ]
  • [ 5316-76-7 ]
YieldReaction ConditionsOperation in experiment
With N-chloro-succinimide; In tetrahydrofuran; acetic acid; ethyl acetate; PREPARATION 2 A mixture of <strong>[6142-15-0]2-amino-4-methylthiazole hydrochloride</strong> 1.5 g) and N-chlorosuccinimide (1.6 g) in acetic acid (15 ml) was heated 40 C. for 5.5 hours with stirring. The reaction mixture was poured into ice water and the solution was adjusted to pH 8.5 using sodium bicarbonate. The mixture was extracted with a mixture of tetrahydrofuran and ethyl acetate (1:1), washed with aqueous saturated sodium chloride and dried over magnesium sulfate. The solvent was concentrated under reduced pressure to give 2-amino-5-chloro-4-methylthiazole (1.4 g, yield: 94.6%, oil). NMR (DMSO-d6, 200 MHZ, ppm): 2.09 (3H, s), 7.00 (2H, br s) Mass: M+2 150, M+1 149, M 148, m/e 133, 113, 99
 

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