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Chemical Structure| 53242-70-9 Chemical Structure| 53242-70-9

Structure of 53242-70-9

Chemical Structure| 53242-70-9

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Product Details of [ 53242-70-9 ]

CAS No. :53242-70-9
Formula : C11H9NO3
M.W : 203.19
SMILES Code : O=C(O)C1=CC(N2C=CC=C2)=CC=C1O
MDL No. :MFCD01321228
InChI Key :RJOWHWZRBQBAMZ-UHFFFAOYSA-N
Pubchem ID :853752

Safety of [ 53242-70-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 53242-70-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53242-70-9 ]

[ 53242-70-9 ] Synthesis Path-Downstream   1~4

YieldReaction ConditionsOperation in experiment
...ogistically active carboxylic acids R1 COOH from which the derivatives of Formula I can be derived, i.e., the following are equivalents of the foregoing mentioned R1 COOH acids as are the corresponding derivatives of this invention equivalents of the aforementioned derivatives. ... 4-(4-chlorophenyl)-2-phenyl-5-thiazolylacetic acid 2-(6-methoxy-2-naphthyl)propionic acid 2-[2-(4-chlorophenyl)benzoxazol-5-yl]propionic acid 4-chloro-3-propenyloxyphenylacetic acid 2-hydroxy-5-(pyrrol-1-yl)benzoic acid 2-hydroxy-5-(2,4-difluorophenyl)benzoic acid 5-fluoro-2-methyl-1-(4-methylsulfynylbenzylidene)indene-3-carboxylic acid 2-hydroxy-5-[2-phenyl(benz[f]indol-1-yl)]benzoic acid ...
  • 2
  • [ 53242-70-9 ]
  • [ 328-74-5 ]
  • N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-(1-pyrrolyl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
57.8% Example 73 N-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxy-5-(pyrrol-1-yl)benzamide (Comopund No. 71). Using 2-hydroxy-5-(pyrrol-1-yl)benzoic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound. Yield: 57.8%. 1H-NMR(DMSO-d6): δ 6.27(2H, dd, J=2.4, 1.8Hz), 7.10(1H, d, J=9.0Hz), 7.29(2H, dd, J=2.4, 1.8Hz), 7.66(1H, dd, J=9.0, 2.7Hz), 7.86(1H, s), 7.98(1H, d, J=2.4Hz), 8.47(2H, s), 10.89(1H, s), 11.24(1H, s).
With pyridine; phosphorus trichloride; In toluene; for 12.0h;Inert atmosphere; Reflux; General procedure: The salicylic acid (1.2 equiv) was added to a mixture of toluene (0.3 M), aniline (1.0 equiv), phosphorus trichloride (1.1 equiv), and pyridine (0.05 equiv) in a Radley’s Carousel reaction tube (modified from Itai et al.20). The mixture was refluxed under nitrogen for 12 h then cooled to room temperature. Aqueous sodium bicarbonate was added dropwise to attain pH 6-7. The resultant mixture was extracted with EtOAc. The organic extracts were combined, dried (MgSO4), and concentrated under vacuum. After chromatography (1:10 EtOAc:Hex) compounds were recrystallized (EtOAc/Hex).
  • 3
  • [ 53242-70-9 ]
  • [ 64399-23-1 ]
  • 2-[2-hydroxy-5-(1-pyrrolyl)benzoyl]amino-4-phenylthiazol-5-carboxylic acid ethylester [ No CAS ]
YieldReaction ConditionsOperation in experiment
55.0% Example 222 2-[2-Hydroxy-5-(1-pyrrolyl)benzoyl] amino-4-phenylthiazole-5-carboxylic acid ethyl ester (Comopund No. 222). Using 2-hydroxy-5-(1-pyrrolyl)benzoic acid and 2-amino-4-phenylthiazole-5-carboxylic acid ethyl ester as the raw materials, the same operation as the example 195(3) gave the title compound. Yield: 55.0%. 1H-NMR(DMSO-d6): δ 1.22(3H, t, J=7.2Hz), 4.22(2H, q, J=7.2Hz), 6.26(2H, t, J=2.1Hz), 7.13(1H, d, J=8.7Hz), 7.32(2H, t, J=2.1Hz), 7.43-7.47(3H, m), 7.70-7.75(3H, m), 8.09(1H, d, J=2.7Hz), 11.58(1H, brs), 12.55(1H, brs).
  • 4
  • [ 696-59-3 ]
  • [ 89-57-6 ]
  • [ 53242-70-9 ]
 

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