Home Cart Sign in  
Chemical Structure| 5325-20-2 Chemical Structure| 5325-20-2

Structure of 5325-20-2

Chemical Structure| 5325-20-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 5325-20-2 ]

CAS No. :5325-20-2
Formula : C8H7NOS
M.W : 165.21
SMILES Code : O=C1NC2=CC=CC=C2SC1
MDL No. :MFCD00006698
InChI Key :GTFMIJNXNMDHAB-UHFFFAOYSA-N
Pubchem ID :21396

Safety of [ 5325-20-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 5325-20-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5325-20-2 ]

[ 5325-20-2 ] Synthesis Path-Downstream   1~4

  • 2
  • [ 105-53-3 ]
  • [ 1141-88-4 ]
  • [ 5325-20-2 ]
  • [ 13920-91-7 ]
  • 4
  • [ 5325-20-2 ]
  • [ 1150271-74-1 ]
  • 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 60.0℃; for 3h;Inert atmosphere; j00634j 2-(4-(Bromomethyl)-3 -fluorophenyl)-4,4,5,5-tetramethyl- 1,3 ,2-dioxaborolane was prepared in three steps from 4-bromo-2-fluoro-1-methylbenzene following the procedure of White, J.R., et al., Tetrahedron Leu. 2010, 51, 3913-3917. In a dry round bottom flask equipped with a stir bar and septum, 2H-benzo[b][1,4]thiazin-3(4H)-one (90 mg, 0.545 mmol), 2-(4-(bromomethyl)-3 -fluorophenyl)-4,4,5,5 -tetramethyl- 1,3,2- dioxaborolane (150 mg, 0.476 mmol), and potassium carbonate (90 mg, 0.652 mmol) were massed. The flask was purged with argon then charged with dry DMF (3 mL). The reaction was stirred at 60 C and monitored by LCMS. After 3 h, reaction was deemed to be complete and cooled to room temperature. The reaction was diluted with ethyl acetate (20 mL), and the organic layer was washed with saturated NaHCO3. The two layers were separated and the aqueous layer was extracted with ethyl acetate (3x20 mL). The organic extracts were combined then washed with saturated LiC1 solution (20 mL) and brine (20 mL). The organic portion was dried over MgSO4, filtered, and concentrated in vacuo. The crude residue was purified by flash column chromatography on silica gel, eluting with hexanes/ethyl acetate to afford 4-(2-fluoro-4-(4,4,5 ,5 -tetramethyl- 1,3 ,2-dioxaborolan-2- yl)benzyl)-2H-benzo[b][1,4]thiazin-3(4H)-one
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 5325-20-2 ]

Amides

Chemical Structure| 21762-31-2

A651820 [21762-31-2]

8-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one

Similarity: 0.98

Chemical Structure| 21762-78-7

A125642 [21762-78-7]

6-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one

Similarity: 0.98

Chemical Structure| 21762-33-4

A634154 [21762-33-4]

N-(3-Oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)acetamide

Similarity: 0.98

Chemical Structure| 92906-38-2

A535086 [92906-38-2]

2-((2-Aminophenyl)thio)-N-phenylacetamide

Similarity: 0.96

Chemical Structure| 30322-02-2

A369651 [30322-02-2]

7-Methyl-2H-benzo[b][1,4]thiazin-3(4H)-one

Similarity: 0.93

Related Parent Nucleus of
[ 5325-20-2 ]

Other Aromatic Heterocycles

Chemical Structure| 21762-31-2

A651820 [21762-31-2]

8-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one

Similarity: 0.98

Chemical Structure| 21762-78-7

A125642 [21762-78-7]

6-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one

Similarity: 0.98

Chemical Structure| 21762-33-4

A634154 [21762-33-4]

N-(3-Oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)acetamide

Similarity: 0.98

Chemical Structure| 30322-02-2

A369651 [30322-02-2]

7-Methyl-2H-benzo[b][1,4]thiazin-3(4H)-one

Similarity: 0.93

Chemical Structure| 5333-05-1

A584571 [5333-05-1]

7-Chloro-2H-benzo[b][1,4]thiazin-3(4H)-one

Similarity: 0.92