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[ CAS No. 5326-50-1 ]

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Chemical Structure| 5326-50-1
Chemical Structure| 5326-50-1
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Product Details of [ 5326-50-1 ]

CAS No. :5326-50-1 MDL No. :MFCD00095227
Formula : C10H18O3 Boiling Point : 262.7°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :186.25 g/mol Pubchem ID :219250
Synonyms :

Safety of [ 5326-50-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5326-50-1 ]

  • Upstream synthesis route of [ 5326-50-1 ]
  • Downstream synthetic route of [ 5326-50-1 ]

[ 5326-50-1 ] Synthesis Path-Upstream   1~16

  • 1
  • [ 108-94-1 ]
  • [ 105-36-2 ]
  • [ 5326-50-1 ]
YieldReaction ConditionsOperation in experiment
94% With iodine; zinc In tetrahydrofuran for 5 h; Heating / reflux Reference Example 61; (1-Hydroxycyclohexyl) ethyl acetate; To a solution of cyclohexanone (9.52 g, 97.0 mmol), a zinc powder (7.6 g, 116.4 mmol) and a small amount of iodine in THF (100 ml) was added dropwise ethyl bromoacetate (11.8 ml, 106.7 mmol) under a nitrogen atmosphere, and the mixture was heated under reflux for 5 hrs. 10percent Sulfuric acid (100 ml) was carefully added under ice-cooling, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous MgS04, and concentrated under reduced pressure to give the title compound (17.2 g, 94percent) as a colorless oil. 1H-NMR (CDCl3) No.: 1 . 27 (3H, t, J=7.0 Hz) , 1.35-1.71 (10H, m), 2.46 (2H, s), 3.43 (lH, s), 4.17 (2H, q, J=7.4 Hz).
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[3] Patent: WO2005/105802, 2005, A1, . Location in patent: Page/Page column 127
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[30] Bulletin de la Societe Chimique de France, 1960, p. 1196 - 1201
[31] Journal of the American Chemical Society, 1981, vol. 103, p. 7550
[32] Journal of Organic Chemistry, 1987, vol. 52, # 21, p. 4796 - 4798
[33] Journal of the American Chemical Society, 1986, vol. 108, p. 1617
[34] Journal of Chemical Research, Miniprint, 1992, # 9, p. 2409 - 2446
[35] Journal of Organic Chemistry, 1985, vol. 50, # 3, p. 416 - 417
[36] Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7902 - 7907
[37] Patent: WO2007/25307, 2007, A2, . Location in patent: Page/Page column 300-301
[38] Synthesis (Germany), 2013, vol. 45, # 17, p. 2391 - 2396
[39] Advanced Synthesis and Catalysis, 2014, vol. 356, # 5, p. 1113 - 1118
[40] Patent: WO2008/106139, 2008, A1, . Location in patent: Page/Page column 470
  • 2
  • [ 108-94-1 ]
  • [ 105-39-5 ]
  • [ 5326-50-1 ]
Reference: [1] Journal of Organic Chemistry, 1991, vol. 56, # 6, p. 2018 - 2024
[2] Journal of the Chemical Society, Chemical Communications, 1986, # 10, p. 775
[3] Advanced Synthesis and Catalysis, 2007, vol. 349, # 3, p. 465 - 468
[4] Tetrahedron, 1998, vol. 54, # 36, p. 10827 - 10836
[5] Journal of Chemical Research, 2004, # 6, p. 406 - 407
[6] Synthesis, 2005, # 8, p. 1297 - 1300
  • 3
  • [ 6975-17-3 ]
  • [ 5326-50-1 ]
Reference: [1] Chemistry Letters, 1988, p. 507 - 508
[2] Tetrahedron, 1997, vol. 53, # 37, p. 12469 - 12486
[3] Chemistry Letters, 1984, p. 271 - 272
[4] Journal of Organic Chemistry, 1971, vol. 36, # 2, p. 330 - 335
[5] Synthesis, 1990, # 10, p. 897 - 899
[6] Tetrahedron Letters, 1987, vol. 28, # 37, p. 4293 - 4296
[7] Tetrahedron Letters, 1987, vol. 28, # 37, p. 4293 - 4296
  • 4
  • [ 27262-60-8 ]
  • [ 5326-50-1 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 493 - 498
  • 5
  • [ 108-94-1 ]
  • [ 141-78-6 ]
  • [ 5326-50-1 ]
Reference: [1] Synthetic Communications, 2005, vol. 35, # 3, p. 379 - 387
[2] Journal of the American Chemical Society, 1955, vol. 77, p. 1050
[3] Tetrahedron Letters, 1976, p. 2253 - 2256
[4] Chemistry - A European Journal, 2000, vol. 6, # 19, p. 3508 - 3516
  • 6
  • [ 108-94-1 ]
  • [ 5326-50-1 ]
Reference: [1] Patent: EP1471056, 2004, A1, . Location in patent: Page 41
  • 7
  • [ 108-94-1 ]
  • [ 623-48-3 ]
  • [ 5326-50-1 ]
Reference: [1] Journal of Organometallic Chemistry, 1989, vol. 369, p. 291 - 296
[2] Synthetic Communications, 1988, vol. 18, # 4, p. 453 - 458
  • 8
  • [ 1552-92-7 ]
  • [ 5326-50-1 ]
  • [ 62281-74-7 ]
Reference: [1] Tetrahedron Letters, 2000, vol. 41, # 50, p. 9725 - 9730
  • 9
  • [ 108-94-1 ]
  • [ 5326-50-1 ]
Reference: [1] Chemische Berichte, 1985, vol. 118, # 4, p. 1421 - 1440
  • 10
  • [ 117668-87-8 ]
  • [ 5326-50-1 ]
Reference: [1] Tetrahedron Letters, 1987, vol. 28, # 37, p. 4293 - 4296
  • 11
  • [ 6975-17-3 ]
  • [ 5326-50-1 ]
  • [ 117668-87-8 ]
Reference: [1] Tetrahedron Letters, 1987, vol. 28, # 37, p. 4293 - 4296
  • 12
  • [ 6975-17-3 ]
  • [ 23974-72-3 ]
  • [ 5326-50-1 ]
  • [ 117668-87-8 ]
Reference: [1] Tetrahedron Letters, 1987, vol. 28, # 37, p. 4293 - 4296
  • 13
  • [ 108-94-1 ]
  • [ 2678-54-8 ]
  • [ 5326-50-1 ]
Reference: [1] Journal of Organic Chemistry, 1969, vol. 34, p. 1181 - 1187
  • 14
  • [ 64-17-5 ]
  • [ 108-94-1 ]
  • [ 64-19-7 ]
  • [ 5326-50-1 ]
Reference: [1] Israel Journal of Chemistry, 1970, vol. 8, p. 731 - 736
  • 15
  • [ 123-19-3 ]
  • [ 56579-97-6 ]
  • [ 108-94-1 ]
  • [ 10297-62-8 ]
  • [ 5326-50-1 ]
Reference: [1] Journal of the Chemical Society, Chemical Communications, 1983, # 8, p. 406 - 408
  • 16
  • [ 123-19-3 ]
  • [ 108-94-1 ]
  • [ 10297-62-8 ]
  • [ 5326-50-1 ]
Reference: [1] Journal of the Chemical Society, Chemical Communications, 1983, # 8, p. 406 - 408
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