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[ CAS No. 53277-43-3 ] {[proInfo.proName]}

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Chemical Structure| 53277-43-3
Chemical Structure| 53277-43-3
Structure of 53277-43-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 53277-43-3 ]

CAS No. :53277-43-3 MDL No. :MFCD19649486
Formula : C7H8N2O Boiling Point : -
Linear Structure Formula :- InChI Key :UCZQHSHTLWCFEW-UHFFFAOYSA-N
M.W : 136.15 Pubchem ID :10773027
Synonyms :

Safety of [ 53277-43-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 53277-43-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53277-43-3 ]

[ 53277-43-3 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 676-58-4 ]
  • [ 15827-84-6 ]
  • [ 53277-43-3 ]
YieldReaction ConditionsOperation in experiment
With oxalic acid In tetrahydrofuran 1 1-(4-Amino-3-pyridinyl)ethanone EXAMPLE 1 1-(4-Amino-3-pyridinyl)ethanone To a solution of 17.72 g (4-amino-3-pyridyl)carbonitrile in 400 ml THF (tetrahydrofuran) at 0° C. was added dropwise 200 ml 3.0M methylmagnesium chloride in THF. After the addition was complete, the reaction mixture was allowed to come to room temperature and stirred twenty-four hours. The reaction was quenched with water. Saturated oxalic acid solution (350 ml) was added, and the mixture was then refluxed for one and a half hours. This mixture was made basic with dilute NaOH solution, and extracted with EtOAc. The extracts were washed with saturated NaCl solution, dried (MgSO4), and concentrated to yield 16.14 g solid. Purification of 1.5 g by flash chromatography and recrystallization from toluene yielded 0.71 g solid, m.p. 161°-163° C. ANALYSIS: Calculated for C7 H8 N2 O: 61.75% C; 5.92% H; 20.57% N. Found: 62.09% C; 5.83% H; 20.34% N.
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