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CAS No. : | 53277-43-3 | MDL No. : | MFCD19649486 |
Formula : | C7H8N2O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | UCZQHSHTLWCFEW-UHFFFAOYSA-N |
M.W : | 136.15 | Pubchem ID : | 10773027 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With oxalic acid In tetrahydrofuran | 1 1-(4-Amino-3-pyridinyl)ethanone EXAMPLE 1 1-(4-Amino-3-pyridinyl)ethanone To a solution of 17.72 g (4-amino-3-pyridyl)carbonitrile in 400 ml THF (tetrahydrofuran) at 0° C. was added dropwise 200 ml 3.0M methylmagnesium chloride in THF. After the addition was complete, the reaction mixture was allowed to come to room temperature and stirred twenty-four hours. The reaction was quenched with water. Saturated oxalic acid solution (350 ml) was added, and the mixture was then refluxed for one and a half hours. This mixture was made basic with dilute NaOH solution, and extracted with EtOAc. The extracts were washed with saturated NaCl solution, dried (MgSO4), and concentrated to yield 16.14 g solid. Purification of 1.5 g by flash chromatography and recrystallization from toluene yielded 0.71 g solid, m.p. 161°-163° C. ANALYSIS: Calculated for C7 H8 N2 O: 61.75% C; 5.92% H; 20.57% N. Found: 62.09% C; 5.83% H; 20.34% N. |