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Chemical Structure| 5331-28-2 Chemical Structure| 5331-28-2

Structure of 5331-28-2

Chemical Structure| 5331-28-2

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Product Details of [ 5331-28-2 ]

CAS No. :5331-28-2
Formula : C16H18O
M.W : 226.31
SMILES Code : CC(C1=CC=C(OC2=CC=CC=C2)C=C1)(C)C
MDL No. :MFCD00026305

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Application In Synthesis of [ 5331-28-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5331-28-2 ]

[ 5331-28-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 3972-56-3 ]
  • [ 108-95-2 ]
  • [ 253185-03-4 ]
  • [ 1625-91-8 ]
  • [ 5331-28-2 ]
  • 2
  • [ 3972-56-3 ]
  • [ 108-95-2 ]
  • [ 1625-91-8 ]
  • [ 5331-28-2 ]
YieldReaction ConditionsOperation in experiment
6%Chromat.; 90% With di-tert-butyl{2?-isopropoxy-[1,1?-binaphthalen]-2-yl}phosphane; sodium hydride; bis(dibenzylideneacetone)-palladium(0); In o-xylene; at 110℃; for 18h;Inert atmosphere;Catalytic behavior; General procedure: An oven-dried Schlenk tube was evacuated and backfilled with nitrogen. The Schlenk tube was charged with NaH (60.0 mg, 60percent,1.2 mmol) and o-xylene (1 mL), and then phenol (1.2 mmol) wasadded. After stirring for 15 min, aryl halide (1.0 mmol) and the solution of Pd(dba)2 (11.5 mg, 0.02 mmol) and L1 (13.7 mg, 0.03 mmol) in o-xylene (1.5 mL) were added sequentially. The septum was replaced with an inside reflux condenser, and then the reaction mixture was stirred for 18 h at 110 C. Then, reaction mixture was cooled to room temperature and quenched with saturated NH4Cl(5 mL). After separating the organic phase, the aqueous phase was extracted with diethyl ether (3 mL3), and the combined organic phase was dried over anhydrous Na2SO4. The solvent was concentrated under reduced pressure, and then the crude material was purified by column chromatography on silica gel.
 

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