[ CAS No. 5333-40-4 ] {[proInfo.proName]}

Name: 5333-40-4|2-(2-Isopropyl-5-methylphenoxy)acetic acid|98%
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SKU: A304642
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Quality Control of [ 5333-40-4 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 5333-40-4 ]

Product Details of [ 5333-40-4 ]

CAS No. :	5333-40-4	MDL No. :	MFCD00021757
Formula :	C₁₂H₁₆O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MURZAHIYMVFXCF-UHFFFAOYSA-N
M.W :	208.25	Pubchem ID :	220116
Synonyms :

Safety of [ 5333-40-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 5333-40-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 5333-40-4 ]

[ 5333-40-4 ] Synthesis Path-Downstream 1~51

1
[ 67-56-1 ]
[ 5333-40-4 ]
[ 111304-01-9 ]

Yield	Reaction Conditions	Operation in experiment
65%	With sulfuric acid for 8h; Reflux;	1.2. Synthesis of methyl 2-(2-isopropyl-5-methylphenoxy)acetate (37) 2-(2-Isopropyl-5-methylphenoxy)acetic acid (10 mmol) was dissolved in 50 mL of dried methanol, and a few drops of concentrated sulfuric acid were added. The mixture was refluxed 8 hours. Next, the solvent was evaporated, and the residue dissolved in 40 mL of ethyl acetate, washed with 0.5% NaOH and brine. The organic layer dried over anhydrous Na2SO4 and filtered. The solvent was evaporated to give the product 37.
	With sulfuric acid

Reference： [1]Ali, Wesam; Więcek, Małgorzata; Łażewska, Dorota; Kurczab, Rafał; Jastrzębska-Więsek, Magdalena; Satała, Grzegorz; Kucwaj-Brysz, Katarzyna; Lubelska, Annamaria; Głuch-Lutwin, Monika; Mordyl, Barbara; Siwek, Agata; Nasim, Muhammad Jawad; Partyka, Anna; Sudoł, Sylwia; Latacz, Gniewomir; Wesołowska, Anna; Kieć-Kononowicz, Katarzyna; Handzlik, Jadwiga [European Journal of Medicinal Chemistry, 2019, vol. 178, p. 740 - 751]
[2]Soper et al. [Journal of the American Chemical Society, 1948, vol. 70, p. 2849,2851]

2
[ 64-17-5 ]
[ 5333-40-4 ]
[ 65101-72-6 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride

Reference： [1]Spica [Gazzetta Chimica Italiana, 1880, vol. 10, p. 345]

3
[ 5333-40-4 ]
[ 1197-37-1 ]
5-ethoxy-2-(2-isopropyl-5-methyl-phenoxymethyl)-1⁽³⁾<i>H</i>-benzimidazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 140 - 150℃;

Reference： [1]Cohn [Journal fur praktische Chemie (Leipzig 1954), 1901, vol. <2> 63, p. 188]

4
[ 5333-40-4 ]
[ 1600-27-7 ]
2-carboxymethoxy-3-isopropyl-6-methyl-phenylmercury ⁽¹⁺⁾-betaine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With water at 70 - 80℃; durch Aufloesen des Reaktionsprodukts in verd. Natronlauge und Einleiten von Kohlendioxyd;

Reference： [1]Current Patent Assignee: Bayer & Co. - DE261229, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 1105][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 1105]

5
[ 5333-40-4 ]
[ 55129-21-0 ]

Yield	Reaction Conditions	Operation in experiment
	With lithium aluminium tetrahydride; diethyl ether

Reference： [1]Kjeldgaard [Farmaceutisk tidende, 1956, vol. 66, p. 49,53]

6
[ 5333-40-4 ]
[ 100121-58-2 ]

Yield	Reaction Conditions	Operation in experiment
61.7%	With PPA; phosphorus pentoxide 1) 30 min, room temperature, 2) 70 deg C, 2 h;
60%	With PPA at 80℃; for 2h;
	With phosphorus pentachloride; benzene Behandeln mit Aluminiumchlorid;

Reference： [1]Hogale; Kharade [Journal of the Indian Chemical Society, 1991, vol. 68, # 5, p. 298 - 299]
[2]Deshmukh, M.; Kharade, D.; Shirke, S. D. [Monatshefte fur Chemie, 1994, vol. 125, # 8/9, p. 971 - 976]
[3]Mameli [Gazzetta Chimica Italiana, 1922, vol. 52 I, p. 328][Gazzetta Chimica Italiana, 1926, vol. 56, p. 764]

7
[ 5333-40-4 ]
[ 31339-06-7 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride
	With thionyl chloride Heating;
	With thionyl chloride In tetrahydrofuran

With thionyl chloride In dichloromethane for 4h;

3 2-isopropyl-5-methylphenyl hydrogen carbonate (0.3g, 1.44mmol) was added to DCM (2ml) followed by the addition of thionyl chloride (4ml) in a round bottom flask. This solution was stirred for 4hrs, and then evaporated. The evaporated flask was then diluted with 4ml of DCM and then added to a solution of (3-amino-4- methoxyphenyl)(morpholino)methanone (0.3g, 1.45mmol) and in DCM (10ml) and triethylamine (0.8ml, 5.81mmol). NaHC03was added to quench the reaction followed by extraction with DCM (20ml x 3 times). The organic layers were collected and dried using MgSC . The mixture was filtered and concentrated in vacuo. The product was purified through column chromatography to form yellow oil (89mg, 14%)[00124]XH NMR (400MHz, CDCI3) d ppm 8.52 (s, 1H), 7.74-7.73 (s, 1H), 7.63-7.61 (d, 1H), 7.34-7.23 (m, 4H), 7.02-7.01 (t, 1H), 6.99-6.92(d, 2H), 4.56 (s, 2H), 3.60-3.566 (t, 2H), 3.42-3.39 (t, 2H), 1.99 (s, 1H), 1.92-1.87 (m, 4H), 1.23-1.19 (t, 1H)[00125]13C NMR (400MHz, CDCI3) d ppm 168.960, 166.525, 157.024, 138.026,136.948, 129.890, 129.053, 123.355, 122.432, 121.386, 118.985, 114.822, 67.556, 60.375, 49.598, 46.250, 26.383, 24.436, 21.039, 14.199

Reference： [1]Bisagni; Royer [Bulletin de la Societe Chimique de France, 1959, p. 521,526] Varma, R. Luxmi; Narayanan, C. S. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 302 - 304]
[2]MAJOR; OHLY [Journal of medicinal and pharmaceutical chemistry, 1961, vol. 4, p. 317 - 326]
[3]CONTI [Bollettino Chimico Farmaceutico, 1961, vol. 100, p. 572 - 575]
[4]Current Patent Assignee: CRITICAL OUTCOME TECH - WO2021/97552, 2021, A1 Location in patent: Paragraph 0097; 00123-00125

8
[ 5333-40-4 ]
[ 17693-39-9 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium chlorate; hydrogen bromide; acetic acid

Reference： [1]Eckstein [Roczniki Chemii, 1958, vol. 32, p. 1357,1361]

9
[ 5333-40-4 ]
(2-isopropyl-4-iodo-5-methyl-phenoxy)-acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With i-Amyl alcohol; iodine; iodic acid

Reference： [1]Mameli; Gambetta; Rimini [Gazzetta Chimica Italiana, 1920, vol. 50 I, p. 183]

10
[ 5333-40-4 ]
[ 636-94-2 ]
[ 99-06-9 ]

Reference： [1]Patent: DE80747,
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 4,p. 151

11
[ 5333-40-4 ]
[ 103-71-9 ]
(2-isopropyl-5-methyl-phenoxy)-acetic acid anilide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 90℃;

Reference： [1]Lambling [Bulletin de la Societe Chimique de France, 1897, vol. <3>17, p. 357]

12
[ 89-83-8 ]
[ 79-11-8 ]
[ 5333-40-4 ]

Yield	Reaction Conditions	Operation in experiment
95%	With sodium hydroxide at 95 - 100℃; for 0.166667h; Microwave irradiation; Green chemistry;	3.2.2. MW Method General procedure: In a 50 mL flask, 1 mmol of phenol (1-15), the appropriate amount of chloroacetic acid (16) andsodium hydroxide (potassium carbonate for nipagins) were mixed.Number of moles of chloroacetic acid (16) and NaOH (K2CO3): 1.2 mmol (0.11 g) of 16 and 2.3 mmol of base for monophenols (1-9) 2.2 mmol (0.21 g) of 16 and 3.3 mmol of base for diphenols (10-12) 3.2 mmol (0.30 g) of 16 and 4.3 mmol of base for triphenols (13-15)A flask with carefully mixed solid reagents was placed in a MW-US reactor and the contentsreacted under MW conditions characterized by the following parameters: MW = 200Wat 95-100° Cfor 10min. After the process was complete, 5 mL of water was added to dissolve of solids andconcentrated hydrochloric acid was added to the reaction mixture until an acidic pH~3 was obtained,to isolate the free products. The separated precipitate was filtered off. The main product was purifiedby crystallization or column chromatography using a mixture of chloroform and methanol (9:1 or 5:1)as an eluent.
87%	Stage #1: thymol With sodium hydroxide In water monomer at 50℃; for 0.5h; Stage #2: chloroacetic acid In water monomer at 50℃; Stage #3: With sulfuric acid	Phenoxy Acid Synthesis General procedure: A phenol compound (thymol, carvacrol, eugenol, vanilin) dissolved in warm waterwas added to a solution of sodium hydroxide (2.1 eq.) in warm water. After mixing for30 min at 50 C, monochloroacetic acid (2.1 eq.) was added. The obtained solution wasmixed overnight at 50 C. After cooling to room temperature, the solution was acidified topH 2 with 10% sulfuric acid. The obtained solid phenoxy acetic acid was separated witha Buchner funnel. Water from the aqueous phase was removed on a rotary evaporator,and the residue was dissolved in hot toluene and washed with water. After separationfrom the organic phase, phenoxyacetic acid was precipitated and separated with a Buchnerfunnel. The combined crude phenoxyacids were dissolved in hot toluene, and activatedcharcoal was added and mixed for 15 min at 50 C. After removing the charcoal from thehot solution, the organic phase was cooled to room temperature, and the obtained solidphenoxyacetic acid was filtrated and dried in vacuum.
50%	With sodium hydroxide In water monomer for 3h; Heating;

32%	With sodium hydroxide In water monomer Reflux;	3 General Procedure 3: Chloroacetic Acid Coupling General procedure: In a round bottom flask equipped with a magnetic stirrer, selected alcohol(1.1 equiv.) was dissolved in dhhO with chloroacetic acid (1 equiv.). Solid NaOH (3 equiv.) was then added to the flask and the reaction was brought to reflux. Once the reaction was deemed complete by TLC analysis, the mixture was cooled to room temperature and carefully acidified with concentrated HCI. The product was filtered off from the solvent and purified by recrystallization (Ethyl Acetate and Hexanes). The product was then characterized by NMR analysis. This compound was prepared following general procedure 3 using Thymol (34.9 g. 232.8 mmol), chloroacetic acid (20 g, 211.7 mmol), and NaOH (25.4 g, 635 mmol) in distilled H2O (75 mL).[00154] No purification was required for this reaction. Pure product, 2-(2-isopropyl-5methylphenoxy)acetic acid, a beigh powder (14.23 g, 32%, Rf= 0.57 in 3:2 EtOAc : Hexanes).1H NMR (400 MHz; CDCI3): d 7.15 (d, J = 7.7, 1H), 6.83 (d, J = 7.7, 1H), 6.58 (s, 1H), 4.70 (s, 2H), 3.36 (7, J = 6.9, 1H), 2.33 (s, 3H), 1.24 (d, J = 6.9, 6H).13C NMR: (400 MHz; CDCI3): d 174.85, 155.01, 136.91, 135.01, 126.85,123.12, 112.84, 65.63, 27.03, 23.25, 21.74
29%	Stage #1: thymol; chloroacetic acid With sodium hydroxide In water monomer at 120℃; for 3h; Heating / reflux; Stage #2: In water monomer at 20℃; Acidic conditions;	7 NaOH beads (66.6 mmol) dissolved in water were added to a mixture of thymol 20 (33.3 mmol), chloroacetic acid 21 (33.3 mmol) and water. The mixture was refluxed at 120 °C for 3 h. The mixture was cooled to room temperature, acidified, extracted with diethyl ether and washed. The solvent was evaporated thus giving precipitated thymolacetic acid 22 with a yield of 29 %. Betulin 1 (7.2 mmol), thymolacetic acid 22 (7.2 mmol), and toluene (80 ml) were heated to 160 °C, followed by the addition of isopropyl titanate (1.4 mmol) to the reaction mixture. The reaction mixture was refluxed for 4.5 h untill all water was separated by the water separation tube. The mixture was cooled to room temperature and the precipitate formed was filtered. The organic phase was washed and the solvent was evaporated. The crude product was recrystallized from boiling solution of cyclohexane and toluene (3.5:1), thus giving 28-carboxymethoxythymol ester of betulin 23 (yield: 61 %) as the reaction product.
29%	Stage #1: thymol; chloroacetic acid With sodium hydroxide In water monomer at 120℃; for 3h; Stage #2: In water monomer at 20℃; Acidic conditions;	7 NaOH beads (66.6 mmol), dissolved in water, were added to a mixture of thymol 20 (33.3 mmol), chloroacetic acid 21 (33.3 mmol) and water. The mixture was refluxed at 120 °C for 3 h. The mixture was cooled to room temperature, acidified, extracted with diethyl ether and washed. The solvent was evaporated thus giving precipitated thymolacetic acid 22 with a yield of 29 %. Betulin 1 (7.2 mmol), thymolacetic acid 22 (7.2 mmol), and toluene (80 ml) were heated to 160 °C, followed by the addition of isopropyl titanate (1.4 mmol) to the reaction mixture. The reaction mixture was refluxed for 4.5 h until all water was separated by water separation tube. The mixture was cooled to room temperature and the pre- cipitate formed was filtered. The organic phase was washed and the solvent was 07 Aug 200736evaporated. The crude product was recrystallized from boiling solution of cyclo- hexane and toluene (3.5:1), thus giving 28-carboxymethoxythymol ester of betulin 23 with a yield of 61 %.
11%	With sodium hydroxide In water monomer at 100℃; for 2h; Inert atmosphere;
	With sodium hydroxide
	With sodium hydroxide
	With sodium hydroxide
	With sodium hydroxide for 3h; Heating;

Reference： [1]Pawełczyk, Anna; Sowa-Kasprzak, Katarzyna; Olender, Dorota; Zaprutko, Lucjusz [Molecules, 2018, vol. 23, # 9]
[2]Bojko, Barbara; Jaroch, Karol; Karolak, Maciej; Krysiński, Jerzy; Materna, Katarzyna; Pałkowski, Łukasz; Podemski, Jonasz; Skrzypczak, Andrzej; Walkiewicz, Filip; Wojcieszak, Marta [Molecules, 2022, vol. 27, # 6]
[3]Varma, Luxmi R; Narayanan, C S [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1991, vol. 30, # 7, p. 676 - 680]
[4]Current Patent Assignee: CRITICAL OUTCOME TECH - WO2021/97552, 2021, A1 Location in patent: Paragraph 0097; 00110-00111; 00153-00156
[5]Current Patent Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND - WO2007/141389, 2007, A1 Location in patent: Page/Page column 60
[6]Current Patent Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND - WO2007/141383, 2007, A1 Location in patent: Page/Page column 35-36
[7]Bauer, Christoph; Byrne, Ryan; Friedrich, Lukas; Gudermann, Thomas; Mederos y Schnitzler, Michael; Schneider, Gisbert; Singh, Inderjeet; Storch, Ursula; Treder, Aaron [ChemMedChem, 2020]
[8]Steinkopf; Hoepner [Journal fur praktische Chemie (Leipzig 1954), 1926, vol. <2> 113, p. 156] Mameli; Gambetta; Rimini [Gazzetta Chimica Italiana, 1920, vol. 50 I, p. 183]
[9]Koelsch [Journal of the American Chemical Society, 1931, vol. 53, p. 304]
[10]Saarbach [Journal fur praktische Chemie (Leipzig 1954), 1880, vol. <2> 21, p. 152] Spica [Gazzetta Chimica Italiana, 1880, vol. 10, p. 345]
[11]Varma, R. Luxmi; Narayanan, C. S. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 302 - 304]

13
[ 5333-40-4 ]
[ 62-53-3 ]
(2-isopropyl-5-methyl-phenoxy)-acetic acid anilide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 150℃;

Reference： [1]Lambling [Bulletin de la Societe Chimique de France, 1897, vol. <3>17, p. 357]

14
[ 5333-40-4 ]
[ 95-55-6 ]
2-(2-isopropyl-5-methyl-phenoxymethyl)-benzoxazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 170℃;

Reference： [1]Cohn [Journal fur praktische Chemie (Leipzig 1954), 1901, vol. <2> 64, p. 294]

15
[ 5333-40-4 ]
[ 141-75-3 ]
[ 1154-97-8 ]

Yield	Reaction Conditions	Operation in experiment
	With aluminium trichloride In carbon disulfide

Reference： [1]Current Patent Assignee: MERCK & CO INC - US3255241, 1966, A [Chem.Abstr., 1966, vol. 65, # 5406][Chem.Abstr., 1966, vol. 65, # 5406]

16
[ 79-08-3 ]
[ 5333-40-4 ]

Yield	Reaction Conditions	Operation in experiment
	With water

Reference： [1]Niederl; Natelson [Journal of the American Chemical Society, 1932, vol. 54, p. 1063,1069]

17
[ 5333-40-4 ]
alkali [ No CAS ]
[ 636-94-2 ]
[ 19420-59-8 ]
[ 99-06-9 ]

Reference： [1]Patent: DE80747,
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 4,p. 151

18
[ 89-83-8 ]
[ 5333-40-4 ]

Yield	Reaction Conditions	Operation in experiment
98%	With sodium hydroxide for 0.0833333h; microwave irradiation;

Reference： [1]More; Pawar; Dewang; Patil; Mahulikar [Russian Journal of General Chemistry, 2004, vol. 74, # 2, p. 217 - 218]

19
betulin [ No CAS ]
[ 5333-40-4 ]
28-carboxymethoxythymol ester of betulin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
61%	In toluene at 160℃; for 4.5h;	7 NaOH beads (66.6 mmol), dissolved in water, were added to a mixture of thymol 20 (33.3 mmol), chloroacetic acid 21 (33.3 mmol) and water. The mixture was refluxed at 120 °C for 3 h. The mixture was cooled to room temperature, acidified, extracted with diethyl ether and washed. The solvent was evaporated thus giving precipitated thymolacetic acid 22 with a yield of 29 %. Betulin 1 (7.2 mmol), thymolacetic acid 22 (7.2 mmol), and toluene (80 ml) were heated to 160 °C, followed by the addition of isopropyl titanate (1.4 mmol) to the reaction mixture. The reaction mixture was refluxed for 4.5 h until all water was separated by water separation tube. The mixture was cooled to room temperature and the pre- cipitate formed was filtered. The organic phase was washed and the solvent was 07 Aug 200736evaporated. The crude product was recrystallized from boiling solution of cyclo- hexane and toluene (3.5:1), thus giving 28-carboxymethoxythymol ester of betulin 23 with a yield of 61 %.

Reference： [1]Current Patent Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND - WO2007/141383, 2007, A1 Location in patent: Page/Page column 35-36

20
[ 473-98-3 ]
[ 5333-40-4 ]
[ 958881-78-2 ]

Yield	Reaction Conditions	Operation in experiment
61%	In toluene at 160℃; for 4.5h; Heating / reflux;	7 NaOH beads (66.6 mmol) dissolved in water were added to a mixture of thymol 20 (33.3 mmol), chloroacetic acid 21 (33.3 mmol) and water. The mixture was refluxed at 120 °C for 3 h. The mixture was cooled to room temperature, acidified, extracted with diethyl ether and washed. The solvent was evaporated thus giving precipitated thymolacetic acid 22 with a yield of 29 %. Betulin 1 (7.2 mmol), thymolacetic acid 22 (7.2 mmol), and toluene (80 ml) were heated to 160 °C, followed by the addition of isopropyl titanate (1.4 mmol) to the reaction mixture. The reaction mixture was refluxed for 4.5 h untill all water was separated by the water separation tube. The mixture was cooled to room temperature and the precipitate formed was filtered. The organic phase was washed and the solvent was evaporated. The crude product was recrystallized from boiling solution of cyclohexane and toluene (3.5:1), thus giving 28-carboxymethoxythymol ester of betulin 23 (yield: 61 %) as the reaction product.

Reference： [1]Current Patent Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND - WO2007/141389, 2007, A1 Location in patent: Page/Page column 60

21
[ 5333-40-4 ]
6-Isopropyl-9-methyl-2,3,4,4a-tetrahydro-dibenzofuran [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 60 percent / polyphosphoric acid / 2 h / 80 °C 2: 73 percent / 1M NaOMe / methanol / 6 h / Heating 3: 69 percent / 2N NaOH / methanol / 6 h / Heating 4: 82 percent / Zn/Hg, conc. HCl / toluene / 26 h / Heating

Reference： [1]Deshmukh, M.; Kharade, D.; Shirke, S. D. [Monatshefte fur Chemie, 1994, vol. 125, # 8/9, p. 971 - 976]

22
[ 5333-40-4 ]
[ 159302-28-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 60 percent / polyphosphoric acid / 2 h / 80 °C 2: 73 percent / 1M NaOMe / methanol / 6 h / Heating 3: 69 percent / 2N NaOH / methanol / 6 h / Heating

Reference： [1]Deshmukh, M.; Kharade, D.; Shirke, S. D. [Monatshefte fur Chemie, 1994, vol. 125, # 8/9, p. 971 - 976]

23
[ 5333-40-4 ]
[ 159302-21-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 60 percent / polyphosphoric acid / 2 h / 80 °C 2: 73 percent / 1M NaOMe / methanol / 6 h / Heating

Reference： [1]Deshmukh, M.; Kharade, D.; Shirke, S. D. [Monatshefte fur Chemie, 1994, vol. 125, # 8/9, p. 971 - 976]

24
[ 5333-40-4 ]
[ 100289-58-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂ 2: 60 percent / NEt₃ / CH₂Cl₂ / Ambient temperature

Reference： [1]Varma, R. Luxmi; Narayanan, C. S. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 302 - 304]

25
[ 5333-40-4 ]
[ 100289-61-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂ 2: 50 percent / NEt₃ / CH₂Cl₂ / Ambient temperature

Reference： [1]Varma, R. Luxmi; Narayanan, C. S. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 302 - 304]

26
[ 5333-40-4 ]
[ 139213-40-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 61.7 percent / polyphosphoric acid, P₂O₅ / 1) 30 min, room temperature, 2) 70 deg C, 2 h 2: 61.2 percent / K₂CO₃ / acetone / 18 h / Heating