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CAS No. : | 5335-75-1 | MDL No. : | MFCD00129015 |
Formula : | C9H13N | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LWMDPZVQAMQFOC-UHFFFAOYSA-N |
M.W : | 135.21 | Pubchem ID : | 138459 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.44 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 43.62 |
TPSA : | 12.89 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -4.9 cm/s |
Log Po/w (iLOGP) : | 2.17 |
Log Po/w (XLOGP3) : | 3.13 |
Log Po/w (WLOGP) : | 2.42 |
Log Po/w (MLOGP) : | 1.8 |
Log Po/w (SILICOS-IT) : | 2.79 |
Consensus Log Po/w : | 2.46 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 2.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.9 |
Solubility : | 0.172 mg/ml ; 0.00127 mol/l |
Class : | Soluble |
Log S (Ali) : | -3.07 |
Solubility : | 0.115 mg/ml ; 0.000851 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -3.59 |
Solubility : | 0.0344 mg/ml ; 0.000255 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.16 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
20% | 4-Picoline (3,00 g, 32.00 mmol) was dissolved in (14 ml) of dry THF and theIQ solution was cooled to -78 0C with an acetone - dry ice bath. n-Butyllithium (16.80 ml, 42.00 mmol) was added slowly while keeping the internal 0T below -50 0C. The reaction was allowed to warm up to room 0T and then stirred at 40 to 45 0C for 2 h. THF (14 ml) was added to dissolve the 4-picolyllithium slurry to give a deep orange solution. The solution was cooled down to 0 0C and carefully added into the solution of 1- i5 bromopropane (5.02 ml, 64.00 mmol) in THF (6.0 ml) at -78 0C. During the addition, the 0T was kept below -65 0C. The reaction was allowed to gradually warm up to room 0T and stirred overnight. The reaction was worked up by adding (1 - 1.5 ml) of H2O. The crude was passed through RSF (Rapid Silica Filtration), eluting with EtOAc (volume = 6 x size of column) and the solvent was evaporated by water aspirator. The residue was further 0 purified by flash chromatography (Hex/EtOAc 1.5/1) and the combined fractions were concentrated by water aspirator to give the above compound as a light yellow liquid (0.73 g, 20 %). 1H NMR (200 MHz, CDCl3): delta 8.46 (2H, d, J = 6.5 Hz, CH (2,6)), 7.09 (2H, d, J= 6.5 Hz, CH(3,5)), 2.59 (2H, t, J= 7.6 Hz, CH2(I ')), 1.64 (2H, m, CH2(2')), 1.31 (2H, m, CH2(3')), 0.91 (3H, t, J= 7.6 Hz3 CH3(4')). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | 1,12-Dibromododecane (0.25 g, 0.76 mmol) was dissolved in 4-methyl-2- pentanone (2.0 ml) and <strong>[5335-75-1]4-butylpyridine</strong> (0.24 g, 1.74 mmol) was added. The mixture was stirred at reflux for 18 h under a nitrogen atmosphere, and the solvent was removed under reduced pressure. The residue was then diluted with H2O (~ 15 ml) and washed with dry20 Et2O (3 x 20 ml). The aqueous layer was extracted with CH2Cl2 (3 x 20 ml), then the CH2Cl2 layer was concentrated under reduced pressure. The residue was purified by Al2O3 chromatography (neutral, activity H-III). using gradient elution (starting with CHCl3MeOH = 2 % to 10 %). The residue was passed down a column of Lewatit MP-64 anion resin (Cl'), eluting with EtOH. The resulting fractions were combined and the 5 solvent removed under reduced pressure to give the above compound as a light yellow waxy oil (0.07 g, 37 %). 1H NMR (300 MHz, CDCl3): delta 9.54 (4H, d, J = 6.5 Hz, CH(2',6')), 7.78 (4H, d, J = 6.5 Hz, CH(3',5')), 4.79 (4H, t, J = 7.6 Hz, CH2(I)), 2.75 (4H, t, J= 7.5 Hz, CH2(I")), 1.92 (4H, m, CH2(2)), 1.57 (4H, m, CH2(2")), 1.26 (12H, m, CH2(3,4,3",4")), 1.10 (8H, m, CH2(5,6)), 0.96 (6H, m, CH3(5")). 13C NMR (300 MHz, o CDCl3): 163.0, 145.2, 128.3, 61.2, 35.8, 32.2, 31.9, 29.6, 29.2, 29.0, 26.2, 22.5, 14.0, MS: <n="31"/>m/z ESI (positive ion) 219 [M-2Clf+ (100 %), 437 [M-2Cr-H+]+ (50). Found [M-2C17 ,2+219.1976, [C15H25Nf |2++ . requires 219.1981. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
39% | In water; | Example 43 Synthesis of compound 1,2-bis-[5-(3-n-butyl-pyridinium)-pentyl]-benzene dibromide A mixture of 1,2-bis-(5-bromo-pentyl)-benzene (232 mg, 0.62 mmol) and <strong>[5335-75-1]4-n-butylpyridine</strong> (0.5 mL) was heated at 60-70 C. for 12 hrs. The resulted mixture was washed with diethyl ether and then dissolved in water (20 mL), the aqueous solution was extracted with chloroform (20 mL*3). Water was removed by lyophilization to afford 154 mg of the title compound. Yield: 39%. 1H NMR (300 MHz, CD3OD) delta 0.98 (t, J=7.2 Hz, 6H), 1.30-1.87 (m, 16H), 2.09 (m, 4H), 2.64 (t, J=7.5 Hz, 4H), 2.92 (t, J-7.2 Hz, 4H), 4.70 (t, J=6.6 Hz, 4H), 6.98-7.18 (m, 4H), 8.05 (dd, J=8.1, 5.4 Hz, 2H), 8.49 (d, J=8.1 Hz, 2H), 9.95 (d, J=5.7 Hz, 2H), 10.08 (s, 2H) ppm; 13C NMR (75 MHz, CD3OD) delta 14.4, 23.3, 27.2, 31.9, 32.6, 33.3, 33.4, 33.8, 62.8, 127.0, 128.9, 130.3, 140.9, 143.3, 145.2, 145.5, 146.5 ppm. |
39% | at 60 - 70℃; for 12h; | A mixture of 1 ,2-6j_?-(5-bromo-pentyl)-benzene (232 mg, 0.62 mmol) and 4-n-25 butylpyridine (0.5 mL) was heated at 60-700C for 12 hrs. The resulted mixture was washed with diethyl ether and then dissolved in water (20 mL), the aqueous solution was extracted with <n="49"/>48chloroform (20 mL chi 3). Water was removed by lyophilization to afford 154 mg of the title compound. Yield: 39 %. 1H NMR (300 MHz, CD3OD) delta 0.98 (t, J = 7.2 Hz, 6H), 1.30-1.87 (m, 16H), 2.09 (m, 4H), 2.64 (t, J = 7.5 Hz, 4H), 2.92 (t, J = 7.2 Hz, 4H), 4.70 (t, J = 6.6 Hz, 4H), 6.98-7.18 (m, 4H), 8.05 (dd, J = 8.1, 5.4 Hz, 2H), 8.49 (d, J = 8.1 Hz, 2H), 9.95 (d, J = 5.7 Hz, 2H), 10.08 (s, 2H) ppm; 13C NMR (75 MHz, CD3OD) delta 14.4, 23.3, 27.2, 31.9, 32.6, 33.3, 33.4, 33.8, 62.8, 127.0, 128.9, 130.3, 140.9, 143.3, 145.2, 145.5, 146.5 ppm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | In water; | Example 57 Synthesis of compound 1,3-bis-[5-(3-n-butyl-pyridinium)-pent-1-ynyl]-benzene dibromide A mixture of 1,3-bis-(5-bromo-pent-1-ynyl)-benzene (242 mg, 0.66 mmol) and <strong>[5335-75-1]4-n-butylpyridine</strong> (0.5 mL) was heated at 60-70 C. for 12 hrs. The resulted mixture was washed with diethyl ether and then dissolved in water (30 mL), the aqueous solution was extracted with chloroform (20 mL*3). Water was removed by lyophilization to afford 347 mg of the title compound. Yield: 83%. 1H NMR (300 MHz, CD3OD) delta 0.98 (t, J=7.2 Hz, 6H), 0.95 (t, J=7.2 Hz, 6H), 1.40 (m, 4H), 1.67 (m, 4H), 2.39 (m, 4H), 2.67 (t, J=6.6 Hz, 4H), 2.88 (t, J=7.8 Hz, 4H), 4.90 (t, J=6.9 Hz, 4H), 7.29 (d, J=1.2 Hz, 3H), 7.33 (s, 1H), 8.07 (dd, J=7.8, 6.0 Hz, 2H), 8.45 (d, J=8.1 Hz, 2H), 9.04 (d, J-6.3 Hz, 2H), 9.14 (s, 2H) ppm; 13C NMR (75 MHz, CD3OD) delta 14.4, 17.3, 23.3, 31.0, 33.3, 33.6, 62.1, 82.1, 89.4, 124.7, 129.0, 129.7, 132.2, 135.4, 143.5, 145.4, 145.5, 146.8 ppm. |
83% | at 60 - 70℃; for 12h; | A mixture of l,3-fc/s-(5-bromo-pent-l-ynyl)-benzene (242 mg, 0.66 mmol) and 4-n- butylpyridine (0.5 mL) was heated at 60-70 0C for 12 hrs. The resulted mixture was washed with diethyl ether and then dissolved in water (30 mL), the aqueous solution was extracted with chloroform (20 mL * 3). Water was removed by lyophilization to afford 347 mg of the title compound. Yield: 83 %. 1H NMR (300 MHz, CD3OD) delta 0.98 (t, J = 7.2 Hz, 6H), 0.95 (t, J = 7.2 Hz, 6H), 1.40 (m, 4H), 1.67 (m, 4H), 2.39 (m, 4H), 2.67 (t, J = 6.6 Hz, 4H), 2.88 (t, J = 7.8 Hz, 4H), 4.90 (t, J = 6.9 Hz, 4H), 7.29 (d, J = 1.2 Hz, 3H), 7.33 (s, IH), 8.07 (dd, J = 7.8, 6.0 Hz, 2H), 8.45 (d, J = 8.1 Hz, 2H), 9.04 (d, J = 6.3 Hz, 2H), 9.14 (s, 2H) ppm; 13C NMR (75 MHz, CD3OD) delta 14.4, 17.3, 23.3, 31.0, 33.3, 33.6, 62.1, 82.1, 89.4, 124.7, 129.0, 129.7, 132.2, 135.4,10 143.5, 145.4, 145.5, 146.8 ppm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With hydrogen;palladium 10% on activated carbon; In methanol; under 760.051 Torr; | 4-Butylpyridine was prepared by adding potassium-t-butoxide (0.68 g, 6 mmol) to propylphosphonium bromide (Aldrich) (2.4 g, 6.0 mmol) in THF (10 mL), at [0 C] and stirring at room temperature for 1 hour. Pyridine-4-carbaldehyde (428 mg, 4 mmol) was added and the reaction mixture stirred for 2h. The reaction mixture was then poured into water and extracted with ethyl acetate. The product obtained after removing the solvent was taken as such in methanol [(30] mL) to which palladium on carbon (10%, [300] mg) was added and hydrogenated at 1 atm pressure over night. Removal of solvent and purification on column chromatography using ethyl acetate resulted in pure product 4-butylpyridine (500 mg, 92%): [[0318] 1H] NMR (CDC13): [8] 8.42 (d, [J=] 6.0, 2), 7.05 (d, [J=] 6.0, 1), 2.60 (t, [J=] 6.5, 2), 1.62 (m, 2), 1. [37] (m, 2), 0.93 (t, [J=] 7.0, 3). MS (ES+): [136 (M+1).] [[0319]] 4-Butylpyridine-2-carboxylic acid, compound [(10B)] (R9 = butyl), was made employing general Method P. To [4-BUTYLPYRIDINE] (2 g, 0. [014] mol) in acetic acid (15 mL), hydrogen peroxide (30%, 5 mL, 0.056 mol) was added and refluxed over night. After removing the solvent, the residue was dissolved in DCM dried over magnesium sulfate and taken as such for the next step. To the compound from the previous step in dichloromethane (10 mL) trimethylsilyl cyanide (3.92 mL, 0.029 mol) and dimethylcarbamoyl chloride (2.67 mL, 0. [028] mol) was added and stirred at room temperature for 24 hours. Aqueous potassium carbonate (10%, 50 mL) was added and extracted with dichloromethane (100 mL). The crude product obtained on removal of solvent was taken up in hydrochloric acid (6N, 30 mL) and refluxed for 24 hours. Removal of acid followed by crystallization of the crude product from acetonitrile resulted in acid [10B] [(R9 =] butyl) [(1.] 5g, 60%). [[0320]'H] NMR [(CDC13)] : 8 8.92 (d, [J=] 6.0, 1), 8.65 (s, 1), 8.27 (m, 1), 3.23 (t, [J=] 6.5, 2), 1.98 (m, 2), 1.67 (m, 2), 1.20 (t, [J=] 7.0, 3). MS (ES-): 178 (M-1). [[0321]] To the amine, compound 2b (Rl=Me, [R=ME),] (140 mg, 0.56 mmol) in DMF (3 mL), BSTFA (0.59 mL, 2.24 mmol) and triethylamine (0.18 mL, 1.26 mmol) were added at [0 C] and then stirred at room temperature for 3 hours. Acid [10B (R9] = butyl) (203 mg, 1.13 mmol) and HATU (319 mg, 0.84 mmol) were added and the reaction mixture was stirred for 4 more hours at room temperature. The DMF was removed and the residue was extracted with ethyl acetate (100 mL) and washed with saturated bicarbonate (40 mL). The product obtained on removal of solvent was taken up in methanol and treated with Dowex [HF] resin for 1 hour. After filtering the resin, methanol was removed to obtain the crude product. The product was then purified on silica gel column using ethyl acetate as eluent to provide for compound [L LB (RL=ME, R2=ME] [R3--H,] R9 = butyl) (200 mg, 86 %). [[0322] 1H] NMR (CDC13) [8] 8.40 (d, J= 4.2, 1), 8.01 (s, 1), 7.29 (m, 1), 5.40 (d, J = 5. 4, [1),] 4.02-4. 36 (m, 3), 4.80 (s, 1), 3.48-3. 60 (m, 1), 3.72 (t, J= 6.0, 2), 2.49 (m, [1),] 2.20 9s, 3), 1. 67 (m, 4), 1.40 [(M,] 3), 0.98-1. 18 (m, 9). Mass 413 [(M+1).] [[0323]] To compound 1 lb (Rl=Me, R2=Me [R3=H,] R9 = butyl) (200 mg, 0.49 mmol} in methanol (5 mL), water (10 mL) and acetic acid (5 mL), platinum dioxide (100 mg, 0.44 mmol) was added and hydrogenated at 60 psi for 16 h. After filtering the catalyst, the solvent was stripped off to obtain the crude product, which was then purified on silica gel column chromatography using 20% methanol in dichloromethane as eluent. The lower Rf fractions provided the title compound (60 mg, 29%). [[0324] 1H] NMR [(CDC13)] : 8 5.20 (d, J= 3.6, 1), 4.20 (dd, J= 3.0, 4.8, 1), 4.04 (m, 2), 3.80 (d, J =3. 0,1), 3.61-3. 66 (m, 1), 3.52 (dd, J= 3.3, 10.2), 2.88 (m, 1), 2.17 (m, 1), 2.14 (s, 3), 1.87 (m, 2), 1.62 (m, 2), 1.32 (m, 6), 0.89 (m, 9); MS (ES+): 419 (M+1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dihydrogen peroxide; acetic acid; In water;Heating / reflux; | 4-Butylpyridine was prepared by adding potassium-t-butoxide (0.68 g, 6 mmol) to propylphosphonium bromide (Aldrich) (2.4 g, 6.0 mmol) in THF (10 mL), at [0 C] and stirring at room temperature for 1 hour. Pyridine-4-carbaldehyde (428 mg, 4 mmol) was added and the reaction mixture stirred for 2h. The reaction mixture was then poured into water and extracted with ethyl acetate. The product obtained after removing the solvent was taken as such in methanol [(30] mL) to which palladium on carbon (10%, [300] mg) was added and hydrogenated at 1 atm pressure over night. Removal of solvent and purification on column chromatography using ethyl acetate resulted in pure product <strong>[5335-75-1]4-butylpyridine</strong> (500 mg, 92%): [[0318] 1H] NMR (CDC13): [8] 8.42 (d, [J=] 6.0, 2), 7.05 (d, [J=] 6.0, 1), 2.60 (t, [J=] 6.5, 2), 1.62 (m, 2), 1. [37] (m, 2), 0.93 (t, [J=] 7.0, 3). MS (ES+): [136 (M+1).] [[0319]] 4-Butylpyridine-2-carboxylic acid, compound [(10B)] (R9 = butyl), was made employing general Method P. To [4-BUTYLPYRIDINE] (2 g, 0. [014] mol) in acetic acid (15 mL), hydrogen peroxide (30%, 5 mL, 0.056 mol) was added and refluxed over night. After removing the solvent, the residue was dissolved in DCM dried over magnesium sulfate and taken as such for the next step. To the compound from the previous step in dichloromethane (10 mL) trimethylsilyl cyanide (3.92 mL, 0.029 mol) and dimethylcarbamoyl chloride (2.67 mL, 0. [028] mol) was added and stirred at room temperature for 24 hours. Aqueous potassium carbonate (10%, 50 mL) was added and extracted with dichloromethane (100 mL). The crude product obtained on removal of solvent was taken up in hydrochloric acid (6N, 30 mL) and refluxed for 24 hours. Removal of acid followed by crystallization of the crude product from acetonitrile resulted in acid [10B] [(R9 =] butyl) [(1.] 5g, 60%). [[0320]'H] NMR [(CDC13)] : 8 8.92 (d, [J=] 6.0, 1), 8.65 (s, 1), 8.27 (m, 1), 3.23 (t, [J=] 6.5, 2), 1.98 (m, 2), 1.67 (m, 2), 1.20 (t, [J=] 7.0, 3). MS (ES-): 178 (M-1). [[0321]] To the amine, compound 2b (Rl=Me, [R=ME),] (140 mg, 0.56 mmol) in DMF (3 mL), BSTFA (0.59 mL, 2.24 mmol) and triethylamine (0.18 mL, 1.26 mmol) were added at [0 C] and then stirred at room temperature for 3 hours. Acid [10B (R9] = butyl) (203 mg, 1.13 mmol) and HATU (319 mg, 0.84 mmol) were added and the reaction mixture was stirred for 4 more hours at room temperature. The DMF was removed and the residue was extracted with ethyl acetate (100 mL) and washed with saturated bicarbonate (40 mL). The product obtained on removal of solvent was taken up in methanol and treated with Dowex [HF] resin for 1 hour. After filtering the resin, methanol was removed to obtain the crude product. The product was then purified on silica gel column using ethyl acetate as eluent to provide for compound [L LB (RL=ME, R2=ME] [R3--H,] R9 = butyl) (200 mg, 86 %). [[0322] 1H] NMR (CDC13) [8] 8.40 (d, J= 4.2, 1), 8.01 (s, 1), 7.29 (m, 1), 5.40 (d, J = 5. 4, [1),] 4.02-4. 36 (m, 3), 4.80 (s, 1), 3.48-3. 60 (m, 1), 3.72 (t, J= 6.0, 2), 2.49 (m, [1),] 2.20 9s, 3), 1. 67 (m, 4), 1.40 [(M,] 3), 0.98-1. 18 (m, 9). Mass 413 [(M+1).] [[0323]] To compound 1 lb (Rl=Me, R2=Me [R3=H,] R9 = butyl) (200 mg, 0.49 mmol} in methanol (5 mL), water (10 mL) and acetic acid (5 mL), platinum dioxide (100 mg, 0.44 mmol) was added and hydrogenated at 60 psi for 16 h. After filtering the catalyst, the solvent was stripped off to obtain the crude product, which was then purified on silica gel column chromatography using 20% methanol in dichloromethane as eluent. The lower Rf fractions provided the title compound (60 mg, 29%). [[0324] 1H] NMR [(CDC13)] : 8 5.20 (d, J= 3.6, 1), 4.20 (dd, J= 3.0, 4.8, 1), 4.04 (m, 2), 3.80 (d, J =3. 0,1), 3.61-3. 66 (m, 1), 3.52 (dd, J= 3.3, 10.2), 2.88 (m, 1), 2.17 (m, 1), 2.14 (s, 3), 1.87 (m, 2), 1.62 (m, 2), 1.32 (m, 6), 0.89 (m, 9); MS (ES+): 419 (M+1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59%Spectr.; 15%Spectr. | General procedure: 20 mL scintillation vial was charged with a solution of MnCl2THF1.6 (3 mol%, 3 mg, 0.012mmol) in 3 mL THF in a glove box. The corresponding electrophile (0.41 mmol, 1 equiv.) andinternal standard, mesitylene (0.41 mmol, 1equiv.), were added. After five minutes of stirring atroom temperature, the Grignard solution (1.2- 2.6 equiv.) was added dropwise and the reactionwas stirred at room temperature. The reaction mixture was removed from the glovebox andquenched with a saturated K2CO3 solution (3 mL) and EtOAc (3 mL). The organic layer wasextracted with EtOAc (3 x 3mL), and dried over MgSO4. The solution was then filtered andconcentrated. The crude product was purified via a silica plug. |
Tags: 5335-75-1 synthesis path| 5335-75-1 SDS| 5335-75-1 COA| 5335-75-1 purity| 5335-75-1 application| 5335-75-1 NMR| 5335-75-1 COA| 5335-75-1 structure
[ 30532-36-6 ]
3-(Pyridin-4-yl)propan-1-amine
Similarity: 0.91
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P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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