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CAS No. : | 53518-18-6 | MDL No. : | MFCD00041843 |
Formula : | C16H14F3NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | VSSSHNJONFTXHS-UHFFFAOYSA-N |
M.W : | 309.28 | Pubchem ID : | 72652 |
Synonyms : |
Coumarin 540A
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
26 % Turnov. | In dichloromethane; 1,1,2-Trichloro-1,2,2-trifluoroethane for 4h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water at 13.5 - 50℃; -ΔG; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With poly (ethylene glycol) 6000; Tween 80 In water at 24.84℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40% | In water at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water-d2 at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In cyclohexane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water-d2 at 80℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water-d2 at 80℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66.54% | With Lawessons reagent In toluene at 110℃; for 12h; Inert atmosphere; | 1 Synthesis of 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline -11-thione Under nitrogen protection, 2.00 g (6.47 mmol) of 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyridine[3,2,1-ij]quinolin-11-one and Lawesson's reagent 3.92 g (9.72 mmol) 1:1.5 equivalent were added to 20 mL of dry re-distilled toluene, and stirred at 110 °C for 12 hours to obtain a red solution; Spin dry the red reaction solution in step a, recrystallize from ethyl acetate to obtain a red solid, namely 9-(trifluoromethyl)-2,3,6,7-tetrahydro-1H, 5H, 11H-pyrano [2,3-f]pyrido[3,2,1-ij]quinoline-11-thione 1.4 g yielded 66.54%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: Lawessons reagent / toluene / 12 h / 110 °C / Inert atmosphere 2.1: sodium hydride / acetonitrile / 0.5 h / 20 °C / Inert atmosphere; Darkness 2.2: 2 h / 20 °C / Inert atmosphere; Darkness 2.3: 1.5 h / 20 °C / Inert atmosphere; Darkness |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: Lawessons reagent / toluene / 12 h / 110 °C / Inert atmosphere 2.1: sodium hydride / acetonitrile / 0.5 h / 20 °C / Inert atmosphere; Darkness 2.2: 2 h / 20 °C / Inert atmosphere; Darkness 2.3: 1.5 h / 20 °C / Inert atmosphere; Darkness 3.1: acetonitrile / 12 h / 80 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: Lawessons reagent / toluene / 15 h / 100 °C / Inert atmosphere 2.1: sodium hydride / acetonitrile / 3 h 2.2: 2 h / 20 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: Lawessons reagent / toluene / 15 h / 100 °C / Inert atmosphere 2.1: sodium hydride / acetonitrile / 3 h 2.2: 2 h / 20 °C / Inert atmosphere 3.1: dichloromethane / 16 h / 20 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: Lawessons reagent / toluene / 15 h / 100 °C / Inert atmosphere 2.1: sodium hydride / acetonitrile / 3 h 2.2: 2 h / 20 °C / Inert atmosphere 3.1: acetonitrile; ethyl acetate / 48 h / 60 °C |