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[ CAS No. 5388-42-1 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 5388-42-1
Chemical Structure| 5388-42-1
Chemical Structure| 5388-42-1
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Product Details of [ 5388-42-1 ]

CAS No. :5388-42-1 MDL No. :MFCD00023020
Formula : C14H11NO Boiling Point : -
Linear Structure Formula :- InChI Key :FIWLYGQHSKZFAQ-UHFFFAOYSA-N
M.W : 209.24 Pubchem ID :97035
Synonyms :

Calculated chemistry of [ 5388-42-1 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 16
Num. arom. heavy atoms : 12
Fraction Csp3 : 0.07
Num. rotatable bonds : 1
Num. H-bond acceptors : 1.0
Num. H-bond donors : 0.0
Molar Refractivity : 66.54
TPSA : 20.31 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.63 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.3
Log Po/w (XLOGP3) : 2.74
Log Po/w (WLOGP) : 2.31
Log Po/w (MLOGP) : 2.88
Log Po/w (SILICOS-IT) : 2.86
Consensus Log Po/w : 2.62

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -3.35
Solubility : 0.0929 mg/ml ; 0.000444 mol/l
Class : Soluble
Log S (Ali) : -2.82
Solubility : 0.316 mg/ml ; 0.00151 mol/l
Class : Soluble
Log S (SILICOS-IT) : -4.7
Solubility : 0.0042 mg/ml ; 0.0000201 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.44

Safety of [ 5388-42-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H317 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5388-42-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5388-42-1 ]

[ 5388-42-1 ] Synthesis Path-Downstream   1~95

  • 1
  • [ 520-03-6 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
86% With ethanol; tetrabutylammonium tetrafluoroborate; diisopropylamine at 20℃; for 3h; Electrochemical reaction; Schlenk technique; Green chemistry; chemoselective reaction;
With hydrogenchloride; tin
With ethanol; sulfuric acid; water at 85℃; Bei der elektrochemischen Reduktion an einer Blei-Kathode;
With hydrogenchloride; samarium diiodide 1.) THF, ca. 20 deg C, 15 min, 2.) THF; Yield given. Multistep reaction;
36 %Chromat. With cobalt(II) bis[bis((trifluoromethyl)sulfonyl)amide]; trimethylsilyl trifluoromethanesulfonate; (p-anisyl)triphos; hydrogen In n-heptane at 125℃; for 18h; Autoclave; Sealed tube;

  • 2
  • [ 87-41-2 ]
  • [ 62-53-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
95% With indium(III) chloride at 200℃; for 6h; Inert atmosphere; Typical Experimental Procedure for the Preparation of Phthalimidine Aniline (0.182 mL, d = 1.022, 2.0 mmol) was added to the reaction flask containing phthalide (0.134 g, 1.0 mmol) and InCl3(0.0442 g, 0.2 mmol) under Ar atmosphere over ca. 3 min with stirring, and the whole mixture was heated at gentle reflux utilizing an oil bath (200 oC) for 12 h. During the rise of temperature, powdered phthalide melted off and fully mixed with aniline. On the other hand, InCl3 partially dissolved to keep the mixture as a suspension throughout the reaction period. Then, the reaction mixture was cooled to room temperature and poured onto ice-cold 1 % HCl, and then extracted with EtOAc. Organic layer was washed by satd. aq. NaHCO3, dried over anhyd. MgSO4, and then filtered. Evaporation gave acrude product, which was purified by column chromatography (silica gel, eluted by hexane-EtOAc) to give pure 2-phenylphthalimidine (0.190 g, 91 %). Other phthalimidine derivatives in the present work were prepared from the combination between appropriate phthalide and primary amine using the similar procedure to that described above. Two 2-(nitrophenyl)-phthaliimidines (trace yields) were merely subjected to 1H NMR spectral comparisons with those of authentic samples previously prepared by us (references 3 and 8 of the main text).
95% With gallium(III) trichloride In neat (no solvent) at 200℃; for 12h; Inert atmosphere;
at 200 - 220℃;
  • 3
  • [ 5388-42-1 ]
  • [ 4770-74-5 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; potassium nitrate
  • 4
  • [ 5388-42-1 ]
  • [ 73357-35-4 ]
YieldReaction ConditionsOperation in experiment
80% With lithium dihydrido-bis(2-methoxyethoxo)aluminate In toluene at 20℃;
With lithium aluminium tetrahydride; diethyl ether
92 %Spectr. With diphenylsilane; potassium <i>tert</i>-butylate In 1,4-dioxane at 110℃; Inert atmosphere; Schlenk technique;
  • 5
  • [ 62-53-3 ]
  • [ 643-79-8 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
80% In N,N-dimethyl-formamide; acetonitrile at 20℃;
66% With 1,2,3-Benzotriazole; 2-hydroxyethanethiol In acetonitrile at 20℃; for 13h; Inert atmosphere; Preparation of 2-[p-(N,N-Diethylamino)phenyl]phthalimidine (1) General procedure: To a solution of o-phthaldehyde (OPT; 1.341 g, 10 mmol) in MeCN (30 mL) was added successively (i) a solution of 2-mercaptoethanol (MET; 6.0 mL, 86 mmol) in MeCN (10 mL) over 3 min, (ii) a solution of N,N-diethylphenylenediamine (1.720 g, 10 mmol) in MeCN (10 mL) over 2 min, (iii)1,2,3-1H-benzotriazole (1.191 g, 10 mmol) portionwise over 2 min, and (iv) pH 9.6 buffer (0.05 MH3BO3-KCl-NaOH; 5 mL) over 3 min with stirring at room temperature. After the additions were complete, the mixture was further stirred at room temperature for 13 h under N2., and then evaporated. After storage in refrigerator for 3 h, the resulting solids were filtered, washed successively with ice-cold Et2O and water, and then dried in vacuo to give crude phthalimidine (1.956 g, mp 145-206 oC). The filtrate was evaporated and diluted with water (100 mL). The further resulting solids were filtered,washed successively with ice-cold Et2O and water, and then dried in vacuo to give another crop of crude product (0.376 g, mp 142-224 oC). Both of the crude samples were combined (2.432 g, 87%) andsubjected to recrystallization from MeOH to give the analytically pure sample of2-[4-(N,N-diethylamino)phenyl]phthalimidine (1; 2.094 g, 72%, mp 149-152 oC) as lemon-yellow needles. Compounds 3-7, 9-16, 21, 22, 24, and 30 were also prepared from the corresponding primary amines using the similar procedure to that described above. In cases of compounds 2 and 8, precipitates appeared during 13 h reaction time, so the reaction mixture was first filtered to collect crude phthalimidine, followed by the work-up described above.
50% With acetic acid In ethyl acetate at 20℃; for 3h;
With diethyl ether
With acetic acid for 0.333333h; Heating;
With acetic acid Yield given;

  • 7
  • [ 33238-23-2 ]
  • [ 5388-42-1 ]
  • [ 66614-81-1 ]
YieldReaction ConditionsOperation in experiment
1: 55% 2: 35% With sodium acetate In ethylene glycol for 1h; Heating;
  • 8
  • [ 201230-82-2 ]
  • [ 50844-92-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
84% With sodium ethanolate In ethanol at 35℃;
  • 9
  • 3a,4-dihydro-1-oxo-4-phenylisoindoline [ No CAS ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
98% In xylene for 24h; Heating;
  • 10
  • (E)-N-benzylidenebenzenamine [ No CAS ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
With dicobalt octacarbonyl; benzene at 230℃;
With dicobalt octacarbonyl; benzene at 325℃;
  • 11
  • [ 5388-42-1 ]
  • [ 7664-93-9 ]
  • [ 4770-74-5 ]
  • 12
  • [ 59473-45-9 ]
  • [ 103-71-9 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
96% Stage #1: 2-(chloromethyl)iodobenzene With isopropylmagnesium bromide In tetrahydrofuran at -30℃; for 1h; Stage #2: phenyl isocyanate In tetrahydrofuran at -20 - 20℃; for 2h; Further stages.;
  • 13
  • [ 33966-11-9 ]
  • [ 27711-59-7 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
70% Stage #1: 2-(hydroxymethyl)-N-phenylbenzamide With isopropylmagnesium chloride In tetrahydrofuran at 50℃; Stage #2: With N,N,N',N'-Tetramethylphosphorodiamidic chloride In tetrahydrofuran at 50℃;
  • 14
  • [ 87-41-2 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: AlCl3 / 1,2-dichloro-ethane 2.1: i-PrMgCl / tetrahydrofuran; various solvent(s) / 50 °C 2.2: 70 percent / ClP(O)(NMe2)2 / tetrahydrofuran; various solvent(s) / 50 °C
Multi-step reaction with 3 steps 1: xylene; phosphorus (V)-sulfide 2: aniline / 190 °C 3: 240 °C
Multi-step reaction with 3 steps 1: chlorine; triphenylphosphine / dichloromethane / 0.08 h / Microwave irradiation 2: triethylamine / dichloromethane / 2.5 h / 20 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 20 °C
  • 15
  • [ 589-09-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 60 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature 2: 99 percent / hexane / Heating 3: 98 percent / 10percent Pd/C / xylene / 24 h / Heating
  • 16
  • [ 75611-67-5 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 60 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature 2: 99 percent / hexane / Heating 3: 98 percent / 10percent Pd/C / xylene / 24 h / Heating
  • 17
  • [ 612-20-4 ]
  • [ 5388-42-1 ]
  • 18
  • [ 5388-42-1 ]
  • [ 75-36-5 ]
  • [ 60025-40-3 ]
YieldReaction ConditionsOperation in experiment
82% With hydrogenchloride In carbon disulfide 1 4-(1-oxo-2-isoindolinyl) acetophenone EXAMPLE 1 4-(1-oxo-2-isoindolinyl) acetophenone To a stirred suspension of N-phenylphthalimidine (20.9 g) in carbon disulfide (400 ml), is added acetyl chloride (13.3 g) at room temperature and the mixture is vigorously stirred while aluminum chloride (39.9 g) is added to this mixture in small portions. The whole mixture is refluxed for 4 hours, allowed to stand overnight and further refluxed for 6 hours. After cooling, the organic layer is decanted and the resulting reddish oil is poured into ice cooled 10% hydrochloric acid (300 ml). The percipitated crystals are collected by filtration, washed with water and dried. Recrystallization from ethanol-chloroform gives pale yellow needles (20.6 g, 82%). Melting point: 243° to 244° C. Elementary analysis calculated for C16 H13 NO2: C, 76.47; H, 5.22; N, 5.57. Found: C, 76.25; H, 5.24; N, 5.61. NMR (CDCl3) δ: 2.60 (3H, singlet, CH3). 4.93 (2H, singlet, CH2 N). 7.5 to 8.2(8H, multiplet, ArH). Mass spectrum (m/e): 251 (M+).
  • 19
  • [ 201230-82-2 ]
  • [ 62-53-3 ]
  • [ 6630-33-7 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
81% With bis(benzonitrile)palladium(II) dichloride; triphenylphosphine In N,N-dimethyl-formamide at 100℃; for 24h; Autoclave;
  • 20
  • [ 1234559-97-7 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
80% With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; potassium carbonate In N,N-dimethyl acetamide at 120℃; for 2h; Inert atmosphere;
  • 21
  • [ 201230-82-2 ]
  • [ 40400-13-3 ]
  • [ 62-53-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
85% With palladium diacetate; triethylamine; triphenylphosphine In N,N-dimethyl-formamide at 50℃; for 48h; chemoselective reaction; 4.2. Cycloaminocarbonylation of 2-iodobenzyl bromide (1) in the presence of primary amines under atmospheric carbon monoxide pressure General procedure: In a typical experiment Pd(OAc)2 (5.6 mg, 0.025 mmol), PPh3 (13.1 mg, 0.05 mmol), 2-iodobenzyl bromide (297 mg,1 mmol), 6 mmol of tert-butylamine (0.63 mL, 6 mmol or 2.2 mmol of amino acid methylester hydrochloride) and 0.5 mL triethylamine were dissolved in DMF (10 mL) under argon in a 100 mL three-necked flask equipped with a gas inlet, reflux condenser with a balloon at the top. The atmosphere was changed to carbon monoxide. The reaction was conducted for the given reaction time upon stirring at 50 °C and analysed by GC-MS. The mixture was then concentrated and evaporated to dryness. The residue was dissolved in chloroform (20 mL) and washed with water (20 mL). The organic phase was thoroughly washed twice with 5% HCl (20 mL), saturated NaHCO3 (20 mL), brine (20 mL), dried over Na2SO4 and concentrated to powder-like crystalline material in case of 2a-c or to a waxy residue in case of 2d,e. All compounds were subjected to column chromatography under the conditions indicated in Section 4.5.
  • 22
  • [ 13169-52-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 2h;
  • 23
  • [ 62-53-3 ]
  • [ 119-67-5 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
99% With formic acid; triethylamine In ethanol at 80℃; for 1h;
98% With (dipyridylamine)Cp*IrOSO3; hydrogen In neat (no solvent) at 110℃; for 16h; Autoclave; chemoselective reaction;
98% With 1,4-diaza-bicyclo[2.2.2]octane; formic acid; palladium diacetate In 1,4-dioxane at 80℃; for 3h; Inert atmosphere;
96% With (2,6-dichlorophenyl)bis(2,3,5,6-tetrafluorophenyl)borane; hydrogen In tetrahydrofuran at 100℃; for 6h; Sealed tube; Molecular sieve; Autoclave; Green chemistry;
96% With formic acid; C22H29IrN4O4S In water at 60℃; for 17h; Schlenk technique;
95% With hydrogen In toluene at 90℃; for 14h; Autoclave;
95% With tris(pentafluorophenyl)borate; phenylsilane In toluene at 120℃; for 1.5h; 4.2. Typical procedures General procedure: The reductive amination of LA and aniline was performed in a thick wall tube with a Teflon screw cap (10 mL volume). In a typical experiment, under air atmosphere, 0.25 mmol LA, 0.25 mmol aniline, 2.5 mol% B(C6F5)3 and 1 mL toluene were added into the reactor. One or three equiv. PhSiH3 was used for the synthesis of pyrrolidone or pyrrolidine respectively. Then, the reactor was heated in oil bath for the desired time. Upon the completion of reaction, the product yield was determined by HPLC with standard curves of pure products. The pure samples were isolated by column chromatography on silica gel with the eluent (petroleum ether:ethyl acetate = 1:1) for pyrrolidones and (petroleum ether: ethyl acetate = 10:1) for pyrrolidines.
94% With carbon monoxide; water In tetrahydrofuran at 120℃; for 12h;
94% With carbon monoxide In tetrahydrofuran; water at 120℃; for 12h; 38 Referring to Equation 2, when 2-formylbenzoic acid is reacted with aniline, isoindolin-1-one is reacted with a high In particular, when 4-methoxyaniline was used as the reaction substrate, a high yield of 98% was obtained. The melting point, NMR and gas chromatography mass spectrometry results of the amine compound prepared in Example 38 are as follows.
94% With 1,4-diaza-bicyclo[2.2.2]octane; formic acid; palladium diacetate In 1,4-dioxane at 80℃; for 1h; General procedure for the synthesis of compounds 3 General procedure: A mixture of 2-formylbenzoic acid (1) (2.0 mmol), amine (2) (2.4 mmol, 1.2 equiv), DABCO (448 mg, 2 equiv), HCOOH (0.5 mL), Pd(OAc)2 (22.5 mg, 0.1 mmol, 5 mol%) in 1,4-dioxane (2 mL) was heated to 80 oC for an appropriate time (Table 3). After completion of the reaction, the mixture was cooled to room temperature, and diluted with DCM (20 mL). The solid was removed by filter, and the filtrate was washed with water (20 mL) and brine (20 mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether/acetone = 5/1, v/v) to afford the product 3.
92% With cobalt(II) phthalocyanine; diphenylsilane In ethanol at 70℃; for 12h; chemoselective reaction;
92% With cobalt(II) phthalocyanine; diphenylsilane In ethanol at 20 - 70℃; for 6h; Green chemistry; chemoselective reaction;
92% Stage #1: aniline; o-carboxybenzaldehyde With tris(pentafluorophenyl)borate In 1,2-dichloro-benzene for 0.25h; Stage #2: With Dimethylphenylsilane; tris(pentafluorophenyl)borate at 100℃; for 1h;
86% With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 20℃; for 5h; Inert atmosphere; 2.Typical procedure for the synthesis of N-substituted isoindolinones: General procedure: A mixture of 2-formylbenzoic acid (1.0 mmol), amine (1.1 mmol), and Hantzsch ester (1.2 mmol) was stirred in CH2Cl2 (3 mL) at room temperature under N2 until the reaction was complete (TLC analysis). A solution of saturated NaHCO3 (5 mL) was added, and was extracted with EtOAc (3×10 mL). The combined organic layers were dried over anhydrous MgSO4 and concentrated to give a residue that was purified by column chromatography with EtOAc/petroleum (1:10-1:3) as an eluent. 3. Characterization data of Products 2-Phenylisoindolin-1-one(3a) [1]: White solid; 180 mg, yield: 86%; m.p.: 162-163. 1H NMR (400 MHz, Chloroform-d) δ 7.93 (d, J = 7.4 Hz, 1H), 7.89 - 7.86 (m, 2H), 7.62 - 7.58 (m, 1H), 7.51 (t, J = 7.6 Hz, 2H), 7.45 - 7.41 (m, 2H), 7.18 (t, J = 7.2 Hz, 1H), 4.86 (s, 2H).
80% With aluminum (III) chloride In ethanol at 25 - 70℃; Inert atmosphere; Schlenk technique;
78% With hydrogen at 130℃; for 12h;
75% With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; acetic acid In 1,4-dioxane at 80℃; for 3h;
Multi-step reaction with 2 steps 1.1: 0.08 h / 70 °C / Microwave irradiation 1.2: 0.08 h / 90 °C / Microwave irradiation 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 25 °C
Multi-step reaction with 2 steps 1: tert-butylbenzene; hydrogen; platinum / 1,4-dioxane / 80 °C / 750.08 Torr / Sealed tube 2: tert-butylbenzene; hydrogen; platinum / 1,4-dioxane / 80 °C / 750.08 Torr / Sealed tube
96 %Chromat. With aluminum (III) chloride In ethanol at 70℃; for 12h; chemoselective reaction;
With hydrogen In toluene at 140℃; for 18h;
95 %Chromat. With hydrogen In methanol at 30℃; for 24h; Autoclave; Green chemistry;
With tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide at 20℃; for 5h; Electrolysis;

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  • 24
  • [ 1374222-82-8 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
90% With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 25℃; for 0.5h;
  • 25
  • [ 28519-62-2 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
With tert-butylbenzene; hydrogen; platinum In 1,4-dioxane at 80℃; Sealed tube;
  • 27
  • [ 5388-42-1 ]
  • [ 33513-42-7 ]
  • [ 1393881-90-7 ]
YieldReaction ConditionsOperation in experiment
69% Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: N-phenylphthalimidine In N,N-dimethyl-formamide at 0 - 80℃; for 6h; Inert atmosphere; Stage #3: With methanol; potassium hydroxide at 20℃; for 1h; Inert atmosphere; 4.3.1. 3-Chloro-2-phenyl-2H-isoindole-1-carbaldehyde 3 POCl3 (1.53 g, 10 mmol) was added dropwise to DMF (0.73 g, 10 mmol) at 0 °C. The mixture was stirred for 30 min at room temperature. After cooling down the solution back to 0 °C, a suspension of 1-phenylisoindolinone 4 (0.7 g, 3.3 mmol) in DMF (2 mL) was added. Subsequently, the reaction mixture was heated at 80 °C for 6 h. Then, after cooling to room temperature, chloroform (10 mL) and ice were added. The organic layer was collected and the chloroform was removed under reduced pressure. Then, KOH (4 M, 5 mL) and MeOH (5 mL) were added to the crude residue, and the mixture was stirred for 1 h at room temperature. The precipitate was filtered, washed with water, and recrystallized from i-PrOH, to give 3 as a light yellow solid (0.58 g, 69%). Mp=98-99 °C. IR (ATR): νCO=1614 cm-11H NMR (acetone-d6): δ=7.36 (t, J=7.8 Hz, 1H, H-5), 7.49 (t, J=7.8 Hz, 1H, H-6), 7.72 (m, 6H, H-4, N-Ph), 8.33 (d, J=7.8 Hz, 1H, H-7), 9.46 (s, 1H, CHO). 13C{1H} NMR (acetone-d6): δ=118.6, 120.5, 122.2, 124.4, 128.2, 128.4, 129.4, 130.2, 135.3, 176.1. UV-vis: λmax (CHCl3): 379 nm (=22,060 L mol-1 cm-1). Fluo (λex=379 nm): λEm=409 nm. MS (DCI/NH3): m/z=256.0 [MH]+. HRMS (DCI/CH4): m/z calcd for C15H11NOCl: 256.0529; found: 256.0529.
  • 28
  • [ 933-88-0 ]
  • [ 62-53-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0 - 20 °C 2.1: iodine; potassium carbonate / acetonitrile / 0.17 h / 20 °C / Sealed tube 2.2: 140 °C / Sealed tube
Multi-step reaction with 2 steps 1: dmap; triethylamine / dichloromethane / 6 h / 0 - 20 °C 2: dmap; copper(l) iodide; di-tert-butyl peroxide / dichloromethane / 24 h / 100 °C / Sealed tube
  • 29
  • [ 7055-03-0 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
86% Stage #1: 2-methyl-N-phenylbenzamide With iodine; potassium carbonate In acetonitrile at 20℃; for 0.166667h; Sealed tube; Stage #2: With di-tert-butyl peroxide In acetonitrile at 140℃; Sealed tube;
82% With dmap; copper(l) iodide; di-tert-butyl peroxide In dichloromethane at 100℃; for 24h; Sealed tube;
  • 30
  • [ 201230-82-2 ]
  • C20H19NO3S [ No CAS ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
93% With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate In acetonitrile at 140℃; for 21h; Autoclave; General procedure for the intramolecularcycloaminocarbonylation of 2-aminomethyl(or 2-alkylcarbamoyl)aryl tosylates andcharacterization General procedure: 2-(Aminomethyl)aryl tosylate (2mmol), Pd(OAc)2 (10 mol %), dppp (15 mol %), K2CO3(2.4 mmol) and CH3CN (70 ml) were charged in a 200ml-autoclave. Theautoclave was flushed and then pressurized with carbon monoxide to 1 MPa, themixture was stirred at 140 oC for 21h. The mixture was cooled toroom temperature and vented to discharge the excess CO. After filtration,solvent was removed under reduced pressure and the crude residue was purifiedby column chromatography on silica gel with petroleum ether-ethyl acetate asthe eluent to afford the desired product.
  • 31
  • [ 131-11-3 ]
  • [ 62-53-3 ]
  • [ 19375-67-8 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
1: 60% 2: 25% With tris(2,4-pentanedionato)ruthenium(III); hydrogen; bis(trifluoromethanesulfonyl)amide; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 150℃; for 18h; Autoclave;
  • 32
  • [ 106-47-8 ]
  • [ 119-67-5 ]
  • [ 5388-42-1 ]
  • [ 4775-27-3 ]
YieldReaction ConditionsOperation in experiment
1: 70% 2: 20% With 1,4-diaza-bicyclo[2.2.2]octane; formic acid; palladium diacetate In 1,4-dioxane at 80℃; for 1h; General procedure for the synthesis of compounds 3 General procedure: A mixture of 2-formylbenzoic acid (1) (2.0 mmol), amine (2) (2.4 mmol, 1.2 equiv), DABCO (448 mg, 2 equiv), HCOOH (0.5 mL), Pd(OAc)2 (22.5 mg, 0.1 mmol, 5 mol%) in 1,4-dioxane (2 mL) was heated to 80 oC for an appropriate time (Table 3). After completion of the reaction, the mixture was cooled to room temperature, and diluted with DCM (20 mL). The solid was removed by filter, and the filtrate was washed with water (20 mL) and brine (20 mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether/acetone = 5/1, v/v) to afford the product 3.
  • 33
  • [ 4122-56-9 ]
  • [ 62-53-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
95% With 1,4-diaza-bicyclo[2.2.2]octane; formic acid; palladium diacetate In 1,4-dioxane at 80℃; for 1h; General procedure for the synthesis of compounds 3a from methyl 2-formylbenzoate (4) A mixture of methyl 2-formylbenzoate (4) (328 mg, 2.0 mmol), aniline (2a) (223 mg, 2.4 mmol, 1.2 equiv), DABCO (448 mg, 2 equiv), HCOOH (0.5 mL), Pd(OAc)2 (22.5 mg, 0.1 mmol, 5 mol%) in 1,4-dioxane (2 mL) was heated to 80 oC for 1 h. After completion of the reaction, the mixture was cooled to room temperature, and diluted with DCM (20 mL). The solid was removed by filter, and the filtrate was washed with water (20 mL) and brine (20 mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether/acetone = 5/1, v/v) to afford the product 3a in 95% yield.
  • 34
  • [ 5388-42-1 ]
  • 2-phenyl-3,3-dideuterioisoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: N-phenylphthalimidine With potassium <i>tert</i>-butylate In 1,4-dioxane at 110℃; for 2h; Schlenk technique; Inert atmosphere; Stage #2: With water-d2 In 1,4-dioxane Schlenk technique; Inert atmosphere;
  • 35
  • [ 480-91-1 ]
  • [ 591-50-4 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
50% With copper (I) iodide; Cs2CO3; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 20 - 120℃; General Procedure A for the Synthesis of Compounds A1~A12. General procedure: Isoindolin-1-one (200 mg, 1.50mmol) was dissolved in super-dry DMSO (4 mL), and Cs2CO3 (1215 mg, 3.75 mmol), CuI (58 mg, 0.30mmol) and N1,N2-dimethylethane-1,2-diamine (27 mg, 33 μL, 0.30 mmol) were added to the solution.The resulting mixture was stirred at room temperature for 10 min, after which iodobenzene (2.25mmol) was added. Then the mixture was heated to 120 °C. When TLC showed that isoindolin-1-onehad been fully converted, the reaction was stopped. The mixture was extracted with ethyl acetate (20mL) and H2O (10 mL). The water phase was re-extracted with ethyl acetate (20 mL). The organic layerwas combined and washed with brine (10 mL). Then the solution was dried over anhydrous MgSO4,filtered and concentrated, and the crude residue was purified by flash chromatography over silica gelusing CH2Cl2/CH3OH as the gradient elution to afford the title compounds.
48% With tripotassium phosphate tribasic; copper (I) iodide In dimethyl sulfoxide at 120℃;
With tripotassium phosphate tribasic; copper (I) iodide In dimethyl sulfoxide at 20 - 110℃; for 24h; Inert atmosphere; Darkness;
With tripotassium phosphate tribasic; copper (I) iodide

  • 36
  • [ 5388-42-1 ]
  • [ 107456-50-8 ]
YieldReaction ConditionsOperation in experiment
14 %Spectr. With potassium phosphate; C30H34BNOPRu; hydrogen In tetrahydrofuran at 150℃; for 24h; Glovebox; Autoclave;
  • 37
  • [ 19375-67-8 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
69% With sodium azide; oxygen; potassium carbonate; eosin Y disodium salt In dimethyl sulfoxide at 20℃; for 16h; Irradiation; Green chemistry;
59% With oxygen; potassium carbonate In dimethyl sulfoxide at 20℃; for 24h; Irradiation; Green chemistry;
55% With 1,4-dioxane at 50℃; for 8h; chemoselective reaction;
42% With 1,4-diaza-bicyclo[2.2.2]octane; 5-methyl-2-furanone; oxygen In tetrahydrofuran at 25℃; for 36h;

  • 38
  • [ 5388-42-1 ]
  • [ 4778-78-3 ]
YieldReaction ConditionsOperation in experiment
81% With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; ammonium peroxydisulfate In trifluoroacetic acid at 80℃; for 15h; Schlenk technique; Inert atmosphere; regioselective reaction;
With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; acetic acid; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 39
  • [ 5388-42-1 ]
  • 2-(2,6-dihydroxyphenyl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; ammonium peroxydisulfate In trifluoroacetic acid at 80℃; for 15h; Schlenk technique; Inert atmosphere; regioselective reaction;
  • 40
  • [ 83-25-0 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
80% With borane-ammonia complex; tris(pentafluorophenyl)borate In 1,2-dichloro-ethane at 60℃; for 16h;
  • 41
  • [ 5388-42-1 ]
  • [ 74-11-3 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 4-chlorobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 42
  • [ 5388-42-1 ]
  • [ 456-22-4 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 4-fluorobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 43
  • [ 5388-42-1 ]
  • [ 535-80-8 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 3-chlorobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 44
  • [ 5388-42-1 ]
  • [ 586-76-5 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 4-bromobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 45
  • [ 5388-42-1 ]
  • [ 619-58-9 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 4-iodobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
50% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 46
  • [ 5388-42-1 ]
  • [ 455-24-3 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 4-(trifluoromethyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
71% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 47
  • [ 5388-42-1 ]
  • [ 121-92-6 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 3-nitrobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 48
  • [ 5388-42-1 ]
  • [ 586-38-9 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 3-methoxybenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
53% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 49
  • [ 5388-42-1 ]
  • [ 445-29-4 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 2-fluorobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 50
  • [ 5388-42-1 ]
  • [ 118-91-2 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 2-chlorobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
36% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 51
  • [ 5388-42-1 ]
  • [ 93-09-4 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl 2-naphthoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 52
  • [ 527-72-0 ]
  • [ 5388-42-1 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl thiophene-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 53
  • [ 88-14-2 ]
  • [ 5388-42-1 ]
  • 2-(1-oxoisoindolin-2-yl)phenyl furan-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With silver hexafluoroantimonate; [RhCl2(p-cymene)]2; silver carbonate In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; Schlenk technique;
  • 54
  • [ 5388-42-1 ]
  • [ 292638-85-8 ]
  • C18H15NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 55
  • [ 5388-42-1 ]
  • [ 292638-85-8 ]
  • C18H15NO3 [ No CAS ]
  • C22H19NO5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
19% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 56
  • [ 5388-42-1 ]
  • [ 140-88-5 ]
  • ethyl (E)-3-(2-(1-oxoisoindolin-2-yl)phenyl)acrylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 57
  • [ 5388-42-1 ]
  • [ 141-32-2 ]
  • C21H21NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 58
  • [ 5388-42-1 ]
  • [ 2495-35-4 ]
  • C24H19NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 59
  • [ 5388-42-1 ]
  • [ 107-13-1 ]
  • C17H12N2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 60
  • [ 5388-42-1 ]
  • [ 107-02-8 ]
  • C17H13NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 61
  • [ 5388-42-1 ]
  • [ 78-94-4 ]
  • C18H15NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
99% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 62
  • [ 100-42-5 ]
  • [ 5388-42-1 ]
  • C22H17NO [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 63
  • [ 5388-42-1 ]
  • [ 405-99-2 ]
  • C22H16FNO [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 64
  • [ 5388-42-1 ]
  • [ 2039-82-9 ]
  • C22H16BrNO [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 65
  • silver hexafluoroantimonate [ No CAS ]
  • [ 100928-22-1 ]
  • [ 5388-42-1 ]
  • C24H25NORu(2+)*2F6Sb(1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% In tetrahydrofuran at 55℃;
  • 66
  • [ 5388-42-1 ]
  • [ 2216-94-6 ]
  • C25H21NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
26% With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) acetate monohydrate In 2-methyltetrahydrofuran at 100℃; for 15h; Schlenk technique; Sealed tube; regioselective reaction;
  • 67
  • [ 5388-42-1 ]
  • [ 98-80-6 ]
  • [ 57877-22-2 ]
YieldReaction ConditionsOperation in experiment
72% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 110℃; for 20h; Inert atmosphere; Schlenk technique;
  • 68
  • [ 5388-42-1 ]
  • [ 1993-03-9 ]
  • 2-(2′-fluoro[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 69
  • [ 5388-42-1 ]
  • [ 5720-06-9 ]
  • 2-(2′-methoxy[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
44% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 70
  • [ 5388-42-1 ]
  • [ 17933-03-8 ]
  • 2-(3′-methyl[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 71
  • [ 5388-42-1 ]
  • [ 10365-98-7 ]
  • 2-(3′-methoxy[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
32% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 72
  • [ 5388-42-1 ]
  • [ 13331-27-6 ]
  • 2-(3′-nitro[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 73
  • [ 5388-42-1 ]
  • [ 172975-69-8 ]
  • 2-(3′,5′-dimethyl[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 74
  • [ 5388-42-1 ]
  • [ 5720-05-8 ]
  • 2-(4′-methyl[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 75
  • [ 5388-42-1 ]
  • [ 5720-07-0 ]
  • 2-(4′-methoxy[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 76
  • [ 5388-42-1 ]
  • [ 1679-18-1 ]
  • 2-(4′-chloro[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 77
  • [ 5388-42-1 ]
  • [ 5467-74-3 ]
  • 2-(4′-bromo[1,1′-biphenyl]-2-yl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 78
  • [ 5388-42-1 ]
  • [ 32316-92-0 ]
  • 2-(2-(naphthalen-2-yl)phenyl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 79
  • [ 5388-42-1 ]
  • [ 156641-98-4 ]
  • 2-(2-(6-methoxynaphthalen-2-yl)phenyl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide In tetrahydrofuran at 90℃; for 20h; Inert atmosphere; Schlenk technique;
  • 80
  • [ 2417-73-4 ]
  • [ 62-53-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
98.04% at 140℃; for 2h; 1 Example 1: In a 25 mL round bottom flask,Add 2.3 g of methyl 2-bromomethylbenzoate and 0.93 g of aniline,Heated up to 140C,Conduct an open reaction for 2h,The progress of the reaction was checked by TLC.When the reaction is complete,Add 10ml of ethanol,Stir for 0.5h and cool down to 25C filtration, ethanol recrystallization and drying to obtain white 2-phenylisoindolin-1-one powder,The yield is 98.04%,Purity was 99.32%.
98% In neat (no solvent) at 140℃; for 2h; General procedure for the synthesis of substituted isoindolinones 3a, 3h ~ 3r, 3v ~ 3x: General procedure: A mixture of substituted methyl 2-(bromomethyl)benzoate 1a, 1h ~ 1r, 1v ~ 1z (10 mmol, 1.0 eq) and substituted amine 2a, 2h ~ 2r, 2v ~ 2x (10 mmol, 1.0 eq) was stirred for 2 h at 140 °C in the round bottom flask. The HBr tail gas absorbtion device was connected to this system throughout. After the completion of the reaction, the mixture was cooled to room temperature and 4 mL ethanol was added, stirred for 5 min. Then the precipitate was collected by filtration and dried to afford 3a, 3h ~ 3r, 3v ~ 3x.
  • 81
  • [ 930-88-1 ]
  • [ 5388-42-1 ]
  • 1-methyl-3-(2-(1-oxoisoindolin-2-yl)phenyl)pyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 82
  • [ 941-69-5 ]
  • [ 5388-42-1 ]
  • 3-(2-(1-oxoisoindolin-2-yl)phenyl)-1-phenylpyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 83
  • [ 63566-53-0 ]
  • [ 5388-42-1 ]
  • 1-(2-fluorophenyl)-3-(2-(1-oxoisoindolin-2-yl)phenyl)pyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 84
  • [ 5388-42-1 ]
  • [ 36817-47-7 ]
  • 1-(2-bromophenyl)-3-(2-(1-oxoisoindolin-2-yl)phenyl)pyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 85
  • [ 5388-42-1 ]
  • [ 4338-06-1 ]
  • 1-(4-nitrophenyl)-3-(2-(1-oxoisoindolin-2-yl)phenyl)pyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 86
  • [ 1631-26-1 ]
  • [ 5388-42-1 ]
  • 1-benzyl-3-(2-(1-oxoisoindolin-2-yl)phenyl)pyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 87
  • [ 5388-42-1 ]
  • [ 140481-02-3 ]
  • 3-(2-(1-oxoisoindolin-2-yl)phenyl)-1-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 88
  • [ 5388-42-1 ]
  • [ 479204-96-1 ]
  • 3-(2-(1-oxoisoindolin-2-yl)phenyl)-1-(thiophen-2-ylmethyl)pyrrolidine-2,5-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate; acetic acid In 1,2-dichloro-ethane at 120℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;
  • 89
  • [ 98-95-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: hydrogen / methanol / 24 h / 30 °C / 7500.75 Torr / Autoclave 2: hydrogen / methanol / 24 h / 30 °C / 7500.75 Torr / Autoclave; Green chemistry
  • 90
  • [ 19375-67-8 ]
  • [ 520-03-6 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
1: 66% 2: 22% With tert.-butylhydroperoxide In 1,4-dioxane; decane at 20℃; for 24h; Irradiation; Overall yield = 88 percent;
  • 91
  • [ 34040-62-5 ]
  • [ 62-53-3 ]
  • [ 5388-42-1 ]
YieldReaction ConditionsOperation in experiment
98% In neat (no solvent) at 140℃; for 2h;
  • 92
  • [ 616-45-5 ]
  • [ 5388-42-1 ]
  • 3-(2-oxopyrrolidin-1-yl)-2-phenylisoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With sodium persulfate; tetrabutylammomium bromide; copper(ll) bromide In 1,2-dichloro-ethane at 80℃; for 24h; Schlenk technique; Inert atmosphere;
  • 93
  • [ 5388-42-1 ]
  • [ 111-66-0 ]
  • 2-(2-(octan-2-yl)phenyl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With [Rh(cod)2]BARF; C48H48O6P2 In 1,4-dioxane at 120℃; for 48h; Inert atmosphere; Sealed tube; General Procedure for the Synthesis of Product (3a-3p) General procedure: In a N2-filled glovebox, a 4 mL baked vial charged with a stir bar and 6.4 mg of[Ir(COD)2]BArF (0.005 mmol), 4.0 mg of rac-L1 (0.005 mmol) was added. Then, 0.2 mLof 1, 4-dioxane was added into the vial and the resulting solution was stirred for 5 min.Then, 1a (21 mg, 0.1 mmol) and 2a (56 mg, 0.5 mmol) were added. The vial was tightlycapped with a screw cap and then removed from the glovebox and placed in a pre-heatedaluminum block at 120 C for 48 h. The reaction mixture was directly purified by columnchromatography on silica gel with EtOAc/PE mixture as an eluent.
  • 94
  • [ 5388-42-1 ]
  • [ 111-66-0 ]
  • C22H27NO [ No CAS ]
  • C22H27NO [ No CAS ]
YieldReaction ConditionsOperation in experiment
74 % ee With [Rh(cod)2]BARF; C48H48O6P2 at 120℃; Inert atmosphere; Sealed tube; Overall yield = 80 percent; General Procedure for the Synthesis of Product (3a-3p) General procedure: In a N2-filled glovebox, a 4 mL baked vial charged with a stir bar and 6.4 mg of[Ir(COD)2]BArF (0.005 mmol), 4.0 mg of rac-L1 (0.005 mmol) was added. Then, 0.2 mLof 1, 4-dioxane was added into the vial and the resulting solution was stirred for 5 min.Then, 1a (21 mg, 0.1 mmol) and 2a (56 mg, 0.5 mmol) were added. The vial was tightlycapped with a screw cap and then removed from the glovebox and placed in a pre-heatedaluminum block at 120 C for 48 h. The reaction mixture was directly purified by columnchromatography on silica gel with EtOAc/PE mixture as an eluent.
  • 95
  • [ 592-41-6 ]
  • [ 5388-42-1 ]
  • 2-(2-(hexan-2-yl)phenyl)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With [Rh(cod)2]BARF; C48H48O6P2 In 1,4-dioxane at 120℃; for 48h; Inert atmosphere; Sealed tube; General Procedure for the Synthesis of Product (3a-3p) General procedure: In a N2-filled glovebox, a 4 mL baked vial charged with a stir bar and 6.4 mg of[Ir(COD)2]BArF (0.005 mmol), 4.0 mg of rac-L1 (0.005 mmol) was added. Then, 0.2 mLof 1, 4-dioxane was added into the vial and the resulting solution was stirred for 5 min.Then, 1a (21 mg, 0.1 mmol) and 2a (56 mg, 0.5 mmol) were added. The vial was tightlycapped with a screw cap and then removed from the glovebox and placed in a pre-heatedaluminum block at 120 C for 48 h. The reaction mixture was directly purified by columnchromatography on silica gel with EtOAc/PE mixture as an eluent.
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