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Chemical Structure| 53985-39-0 Chemical Structure| 53985-39-0

Structure of 53985-39-0

Chemical Structure| 53985-39-0

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Product Details of [ 53985-39-0 ]

CAS No. :53985-39-0
Formula : C15H11F3O3
M.W : 296.24
SMILES Code : O=C(O)C1=CC(C(F)(F)F)=CC(OCC2=CC=CC=C2)=C1

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Application In Synthesis of [ 53985-39-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53985-39-0 ]

[ 53985-39-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 100-51-6 ]
  • [ 161622-05-5 ]
  • [ 53985-39-0 ]
YieldReaction ConditionsOperation in experiment
58% 1 g (4.8 mmol) of <strong>[161622-05-5]3-trifluoromethyl-5-fluorobenzoic acid</strong> was dissolved in 10 mL of dimethylformamide, then 623 mg (5.76 mmol) of benzyl alcohol was added thereto dropwise. 423 mg (60%, 10.5 mmol) of sodium hydride was slowly added to the reaction solution at 0C, and stirred for 10 minutes, then the solution was heated at 50 C for 4 hours. The reaction solution was diluted with ethyl acetate and washed with water, and then dried over anhydrous magnesium sulfate. Solvent was removed and the residue was purified by column chromatography to obtain 825 mg of the title compound in a yield of 58%.NMR: 1H-NMR(CDCl3) delta 7.95(1H, s), 7.85(1H, s), 7.50~7.30(6H, m), 5.13(2H, s)Mass(EI) 297 (M++l)
  • 2
  • [ 161622-05-5 ]
  • [ 53985-39-0 ]
 

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