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Chemical Structure| 53985-48-1 Chemical Structure| 53985-48-1

Structure of 53985-48-1

Chemical Structure| 53985-48-1

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Product Details of [ 53985-48-1 ]

CAS No. :53985-48-1
Formula : C9H7F3O3
M.W : 220.15
SMILES Code : O=C(O)C1=CC(C(F)(F)F)=CC(OC)=C1
MDL No. :MFCD09025409
InChI Key :VAQSHRZOMRFBCX-UHFFFAOYSA-N
Pubchem ID :21544467

Safety of [ 53985-48-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 53985-48-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53985-48-1 ]

[ 53985-48-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 161622-05-5 ]
  • [ 53985-48-1 ]
YieldReaction ConditionsOperation in experiment
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium methylate; at 120℃; (i) 3-methoxy-5-(trifluoromethyl)benzoic acid Sodium methoxide (13.0 g) was added to a stirred solution of <strong>[161622-05-5]3-fluoro-5-trifluoromethyl benzoic acid</strong> (25.0 g) in DMPU (200 ml) and heated at 120 C. overnight. The reaction was poured onto 2M HCl (800 ml). The resulting solid formed was filtered and washed with water, then dried in vacuo to give the subtitle compound (23.0 g). 1H NMR DMSO-d6: 7.75 (1H, s), 7.70 (1H, s), 7.51 (1H, s), 3.90 (3H, s).
 

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