Alternatived Products of [ 5407-86-3 ]
Product Details of [ 5407-86-3 ]
CAS No. : 5407-86-3
MDL No. : MFCD00975063
Formula :
C7 H8 Br2 N2
Boiling Point : -
Linear Structure Formula : -
InChI Key : CPQZUZPWNKOMCC-UHFFFAOYSA-N
M.W : 279.96 g/molPubchem ID : 223259
Synonyms :
Calculated chemistry of [ 5407-86-3 ]
Physicochemical Properties
Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.29
Num. rotatable bonds : 0
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 53.97
TPSA : 38.91 Ų
Pharmacokinetics
GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.13 cm/s
Lipophilicity
Log Po/w (iLOGP) : 2.25
Log Po/w (XLOGP3) : 2.65
Log Po/w (WLOGP) : 2.81
Log Po/w (MLOGP) : 2.38
Log Po/w (SILICOS-IT) : 2.88
Consensus Log Po/w : 2.59
Druglikeness
Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55
Water Solubility
Log S (ESOL) : -3.65
Solubility : 0.0628 mg/ml ; 0.000224 mol/l
Class : Soluble
Log S (Ali) : -3.12
Solubility : 0.213 mg/ml ; 0.000762 mol/l
Class : Soluble
Log S (SILICOS-IT) : -4.14
Solubility : 0.0202 mg/ml ; 0.0000721 mol/l
Class : Moderately soluble
Medicinal Chemistry
PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 1.86
Application In Synthesis of [ 5407-86-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Downstream synthetic route of [ 5407-86-3 ]
1
[ 5407-86-3 ]
3,5-dibromo-4,6-dimethyl-pyridin-2-ol
[ No CAS ]
Yield Reaction Conditions Operation in experiment
With hydrogenchloride; water; sodium nitrite
2
[ 5407-87-4 ]
[ 5407-86-3 ]
Yield Reaction Conditions Operation in experiment
75%
Stage #1: 2-Amino-4,6-dimethylpyridine With bromine; acetic acid at 20℃; for 1.25h; Inert atmosphere;
Stage #2: With sodium hydroxide Inert atmosphere; Cooling with ice;
56.92%
With bromine; acetic acid
38%
With bromine In acetic acid at 20℃; for 3h;
With tetrachloromethane; N-Bromosuccinimide; dibenzoyl peroxide Irradiation;
With water; bromine; acetic acid
Reference：
[1]Location in patent: experimental part
Zhang, Feng; Zaidi, Saheem; Haney, Kendra M.; Kellogg, Glen E.; Zhang, Yan
[Journal of Organic Chemistry, 2011, vol. 76, # 19, p. 7945 - 7952]
[2]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
[3]Collin; Robert; Robert; Le Baut; Bobin-Dubigeon; Grimaud; Lang; Petit
[Pharmacy and Pharmacology Communications, 1999, vol. 5, # 3, p. 233 - 238]
[4]Mariella; Belcher
[Journal of the American Chemical Society, 1952, vol. 74, p. 1916,1918]
[5]Mariella; Belcher
[Journal of the American Chemical Society, 1952, vol. 74, p. 1916,1918]
3
[ 5407-86-3 ]
[ 17157-48-1 ]
[ 178488-35-2 ]
Yield Reaction Conditions Operation in experiment
55%
In ethanol Heating;
Reference：
[1]Gueiffier, Alain; Lhassani, Mohammed; Elhakmaoui, Ahmed; Snoeck, Robert; Andrei, Graciela; Chavignon, Olivier; Teulade, Jean-Claude; Kerbal, Abdelali; Essassi, El Mokhtar; Debouzy, Jean-Claude; Witvrouw, Myriam; Blache, Yves; Balzarini, Jan; De Clercq, Erik; Chapat, Jean-Pierre
[Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859]
4
[ 85-44-9 ]
[ 5407-86-3 ]
2-(3,5-dibromo-4,6-dimethyl-pyridin-2-yl)-isoindole-1,3-dione
[ No CAS ]
Yield Reaction Conditions Operation in experiment
40%
In acetic acid for 24h; Heating;
Reference：
[1]Collin, Xavier; Robert, Jean-Michel; Wielgosz, Gaetane; Le Baut, Guillaume; Bobin-Dubigeon, Christine; Grimaud, Nicole; Petit, Jean-Yves
[European Journal of Medicinal Chemistry, 2001, vol. 36, # 7-8, p. 639 - 649]
5
[ 5407-86-3 ]
[ 602-94-8 ]
N-(3,5-dibromo-4,6-dimethylpyridin-2-yl)pentafluorobenzamide
[ No CAS ]
Yield Reaction Conditions Operation in experiment
49%
With O-phenyl phosphorodichloridate; triethylamine In 1,2-dichloro-ethane at 20℃; for 24h;
6
[ 5407-86-3 ]
[ 1026274-09-8 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 3 steps
1: 55 percent / ethanol / Heating
2: 35 percent / AcOH, AcONa / 2 h / 90 °C
3: SOCl2 / Heating
Reference：
[1]Gueiffier, Alain; Lhassani, Mohammed; Elhakmaoui, Ahmed; Snoeck, Robert; Andrei, Graciela; Chavignon, Olivier; Teulade, Jean-Claude; Kerbal, Abdelali; Essassi, El Mokhtar; Debouzy, Jean-Claude; Witvrouw, Myriam; Blache, Yves; Balzarini, Jan; De Clercq, Erik; Chapat, Jean-Pierre
[Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859]
7
[ 5407-86-3 ]
[ 178488-42-1 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 2 steps
1: 55 percent / ethanol / Heating
2: 35 percent / AcOH, AcONa / 2 h / 90 °C
Reference：
[1]Gueiffier, Alain; Lhassani, Mohammed; Elhakmaoui, Ahmed; Snoeck, Robert; Andrei, Graciela; Chavignon, Olivier; Teulade, Jean-Claude; Kerbal, Abdelali; Essassi, El Mokhtar; Debouzy, Jean-Claude; Witvrouw, Myriam; Blache, Yves; Balzarini, Jan; De Clercq, Erik; Chapat, Jean-Pierre
[Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859]
8
[ 5407-86-3 ]
2-(6,8-Dibromo-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylmethylsulfanyl)-ethanol
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: 55 percent / ethanol / Heating
2: 35 percent / AcOH, AcONa / 2 h / 90 °C
3: SOCl2 / Heating
4: pyridine / acetonitrile / Heating
Reference：
[1]Gueiffier, Alain; Lhassani, Mohammed; Elhakmaoui, Ahmed; Snoeck, Robert; Andrei, Graciela; Chavignon, Olivier; Teulade, Jean-Claude; Kerbal, Abdelali; Essassi, El Mokhtar; Debouzy, Jean-Claude; Witvrouw, Myriam; Blache, Yves; Balzarini, Jan; De Clercq, Erik; Chapat, Jean-Pierre
[Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859]
9
[ 5407-86-3 ]
3-Benzylsulfanylmethyl-6,8-dibromo-5,7-dimethyl-imidazo[1,2-a]pyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: 55 percent / ethanol / Heating
2: 35 percent / AcOH, AcONa / 2 h / 90 °C
3: SOCl2 / Heating
4: pyridine / acetonitrile / Heating
Reference：
[1]Gueiffier, Alain; Lhassani, Mohammed; Elhakmaoui, Ahmed; Snoeck, Robert; Andrei, Graciela; Chavignon, Olivier; Teulade, Jean-Claude; Kerbal, Abdelali; Essassi, El Mokhtar; Debouzy, Jean-Claude; Witvrouw, Myriam; Blache, Yves; Balzarini, Jan; De Clercq, Erik; Chapat, Jean-Pierre
[Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859]
10
[ 5407-86-3 ]
2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethyl-3,5-di((Z)-dec-1-enyl)pyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 6 h / Inert atmosphere; Reflux
11
[ 5407-86-3 ]
2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethyl-3,5-di((E)-dec-1-enyl)pyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 6 h / Inert atmosphere; Reflux
12
[ 5407-86-3 ]
2-(3-(4-methoxybenzyloxy)propyl)-3-((E)-dec-1-enyl)-5-((Z)-dec-1-enyl)-4,6-dimethylpyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 5 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
5: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 4 h / Inert atmosphere; Reflux
13
[ 5407-86-3 ]
2-(3-(4-methoxybenzyloxy)propyl)-3-((Z)-dec-1-enyl)-5-((E)-dec-1-enyl)-4,6-dimethylpyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 5 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
5: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 4 h / Inert atmosphere; Reflux
14
[ 5407-86-3 ]
[ 1333320-16-3 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 2 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
15
[ 5407-86-3 ]
[ 1333320-19-6 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 3 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
16
[ 5407-86-3 ]
[ 1333320-21-0 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 5 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 6 h / Inert atmosphere; Reflux
5: hydrogenchloride; water / ethanol / 3 h / Reflux
17
[ 5407-86-3 ]
[ 1333320-12-9 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 6 h / Inert atmosphere; Reflux
5: hydrogenchloride; water / ethanol / 3 h / Reflux
6: methanesulfonyl chloride; triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
18
[ 5407-86-3 ]
[ 1333320-23-2 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 5 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 6 h / Inert atmosphere; Reflux
5: hydrogenchloride; water / ethanol / 3 h / Reflux
19
[ 5407-86-3 ]
[ 1333320-24-3 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
20
[ 5407-86-3 ]
[ 1333320-25-4 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
21
[ 5407-86-3 ]
[ 1333320-27-6 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
5: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 4 h / Inert atmosphere; Reflux
6: hydrogenchloride; water / ethanol / 3 h / Reflux
22
[ 5407-86-3 ]
[ 1333320-14-1 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 7 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
5: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 4 h / Inert atmosphere; Reflux
6: hydrogenchloride; water / ethanol / 3 h / Reflux
7: methanesulfonyl chloride; triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
23
[ 5407-86-3 ]
[ 1333320-29-8 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
5: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 4 h / Inert atmosphere; Reflux
6: hydrogenchloride; water / ethanol / 3 h / Reflux
24
[ 5407-86-3 ]
[ 1333320-15-2 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 7 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
5: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 4 h / Inert atmosphere; Reflux
6: hydrogenchloride; water / ethanol / 3 h / Reflux
7: methanesulfonyl chloride; triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
25
[ 5407-86-3 ]
[ 18028-51-8 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 3 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3102.97 Torr
26
[ 5407-86-3 ]
[ 5006-58-6 ]
Yield Reaction Conditions Operation in experiment
88%
Stage #1: 3,5-dibromo-4,6-dimethylpyridin-2-amine With tert.-butylnitrite; bromine In Bromoform at 20℃; for 2h;
Stage #2: With sodium carbonate In Bromoform
75.18%
With hydrogen bromide; bromine; sodium carbonate
Reference：
[1]Location in patent: experimental part
Zhang, Feng; Zaidi, Saheem; Haney, Kendra M.; Kellogg, Glen E.; Zhang, Yan
[Journal of Organic Chemistry, 2011, vol. 76, # 19, p. 7945 - 7952]
[2]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
27
[ 5407-86-3 ]
3,5-di((E)-dec-1-en-1-yl)-2-(3-methoxypropyl)-4,6-dimethylpyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
3: hydrogen; triethylamine; platinum(IV) oxide / ethanol
4: palladium diacetate; triphenylphosphine; sodium carbonate
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
28
[ 5407-86-3 ]
3-((E)-dec-1-en-1-yl)-5-((Z)-dec-1-en-1-yl)-2-(3-methoxypropyl)-4,6-dimethylpyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 5 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
3: hydrogen; triethylamine; platinum(IV) oxide / ethanol
4: palladium diacetate; triphenylphosphine; sodium carbonate
5: palladium diacetate; triphenylphosphine; sodium carbonate
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
29
[ 5407-86-3 ]
5-((E)-dec-1-en-1-yl)-3-((Z)-dec-1-en-1-yl)-2-(3-methoxypropyl)-4,6-dimethylpyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 5 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
3: hydrogen; triethylamine; platinum(IV) oxide / ethanol
4: palladium diacetate; triphenylphosphine; sodium carbonate
5: palladium diacetate; triphenylphosphine; sodium carbonate
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
30
[ 5407-86-3 ]
3,5-didecyl-2-(3-methoxypropyl)-4,6-dimethylpyridine
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 6 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
3: hydrogen; triethylamine; platinum(IV) oxide / ethanol
4: palladium diacetate; triphenylphosphine; sodium carbonate
5: palladium diacetate; triphenylphosphine; sodium carbonate
6: hydrogen; palladium on activated charcoal / methanol
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
31
[ 5407-86-3 ]
[ 1392469-44-1 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 2 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
32
[ 5407-86-3 ]
[ 1392469-45-2 ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 3 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
3: hydrogen; triethylamine; platinum(IV) oxide / ethanol
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
33
[ 5407-86-3 ]
C21 H34 BrNO
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
3: hydrogen; triethylamine; platinum(IV) oxide / ethanol
4: palladium diacetate; triphenylphosphine; sodium carbonate
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
34
[ 5407-86-3 ]
C21 H34 BrNO
[ No CAS ]
Yield Reaction Conditions Operation in experiment
Multi-step reaction with 4 steps
1: sodium carbonate; bromine; hydrogen bromide
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine
3: hydrogen; triethylamine; platinum(IV) oxide / ethanol
4: palladium diacetate; triphenylphosphine; sodium carbonate
Reference：
[1]Du, Yongle; Valenciano, Ana Lisa; Dai, Yumin; Zheng, Yi; Zhang, Feng; Zhang, Yan; Clement, Jason; Goetz, Michael; Kingston, David G. I.; Cassera, Maria B.
[Journal of Natural Products, 2020, vol. 83, # 3, p. 569 - 577]
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
Life Science
For Research Only
100K+ Compounds
Competitive Price
1-2 Day Shipping
