Alternatived Products of [ 541-23-1 ]
Product Details of [ 541-23-1 ]
CAS No. : | 541-23-1 |
MDL No. : | MFCD00050684 |
Formula : |
C5H14ClN
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
123.62
|
Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 541-23-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 541-23-1 ]
- Downstream synthetic route of [ 541-23-1 ]
- 1
-
[ 627-67-8 ]
-
[ 541-23-1 ]
Yield | Reaction Conditions | Operation in experiment |
82% |
With ammonium formate In methanol Ambient temperature; |
|
- 2
-
[ 107-85-7 ]
-
[ 2695-37-6 ]
-
[ 541-23-1 ]
-
4-vinyl-benzenesulfonic acid; compound with 3-methyl-butylamine
[ No CAS ]
- 3
-
[ 541-23-1 ]
-
[ 61798-06-9 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: NaHSO3; water
2: sodium; butanol; toluene |
|
- 4
-
[ 96-26-4 ]
-
[ 541-23-1 ]
-
[ 38993-84-9 ]
-
[ 226930-98-9 ]
Yield | Reaction Conditions | Operation in experiment |
52% |
|
38-1) 5-Hydroxymethyl-1-(3-methyl)butylimidazole The title compound was obtained in a yield of 52percent according to the same procedure as Preparation 31-1) using dihydroxyacetone and isoamylamine hydrochloride as starting materials. 1H NMR(CDCl3) delta0.90(d, 6H), 1.32(m, 2H), 1.65(m, 1H), 3.67(t, 2H), 4.23(brs, 1H), 4.60(s, 2H), 6.84(s, 1H), 7.44(s, 1H) |
- 5
-
[ 34306-42-8 ]
-
[ 541-23-1 ]
-
(S)-2-(tert-butoxycarbonylamino)-N-isopentylbutanamide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
71% |
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; |
2 4.2.6. General procedure for amide coupling
General procedure: To a cooled solution of Boc-L-leucine (1.0 equiv.), the amine/α-aminoester HCl (1.2-1.5 equiv.), and PyBop 1.2 equiv. (or EDCI*HCl1.2 equiv. and HOBt 1.2 equiv.) in anhydrous DMF was added diisopropylethylamine (3.3-4.0 equiv.) gradually. The reaction mixture was stirred at room temperature for 5 h to overnight, diluted with ethyl acetate (50 mL for every 5 mL DMF), then extracted with 1 M HCl (3), saturated sodium bicarbonate (3), and brine (2). The organic layer was then dried with anhydrous sodium sulfate and the solvent was evaporated under vacuum to give the products which were purified by flash chromatography whenever needed. |
- 6
-
[ 53308-95-5 ]
-
[ 541-23-1 ]
-
(S)-2-(tert-butoxycarbonylamino)-N-isopentylpentanamide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
69% |
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; |
General procedure: To a cooled solution of Boc-L-leucine (1.0 equiv.), the amine/alpha-aminoester HCl (1.2-1.5 equiv.), and PyBop 1.2 equiv. (or EDCI*HCl1.2 equiv. and HOBt 1.2 equiv.) in anhydrous DMF was added diisopropylethylamine (3.3-4.0 equiv.) gradually. The reaction mixture was stirred at room temperature for 5 h to overnight, diluted with ethyl acetate (50 mL for every 5 mL DMF), then extracted with 1 M HCl (3), saturated sodium bicarbonate (3), and brine (2). The organic layer was then dried with anhydrous sodium sulfate and the solvent was evaporated under vacuum to give the products which were purified by flash chromatography whenever needed. |