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Chemical Structure| 54396-42-8 Chemical Structure| 54396-42-8

Structure of 54396-42-8

Chemical Structure| 54396-42-8

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Product Details of [ 54396-42-8 ]

CAS No. :54396-42-8
Formula : C16H15F3N2O2
M.W : 324.30
SMILES Code : O=C(OCC)C1=C(NC2=CC=CC(C(F)(F)F)=C2C)N=CC=C1
MDL No. :MFCD29924013
Boiling Point : No data available

Safety of [ 54396-42-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Application In Synthesis of [ 54396-42-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54396-42-8 ]

[ 54396-42-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 54396-44-0 ]
  • [ 1452-94-4 ]
  • [ 54396-42-8 ]
  • 2
  • [ 54396-44-0 ]
  • [ 54396-42-8 ]
  • [ 1452-94-4 ]
  • [ 38677-85-9 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In methanol; water; EXAMPLE 4 2-(2'-Methyl-3'-trifluoromethylanilino) nicotinic acid To 20 g. of <strong>[54396-44-0]2-methyl-3-trifluoromethyl aniline</strong> heated at 200°, add, in a dropwise fashion, 11 g. of ethyl 2-chloro-nicotinate. Heat the reaction mixture at 200° for one-half hour, cool, pour the mixture onto ice and extract with ether. Concentrate the ether extracts, dry and fractionate the residue in vacuo; b.p. 143°-146°/0.15 mm; m.p. 44°-46°. To a solution of 12 g. of ethyl 2-(2'-methyl-3'-trifluoromethylanilino) nicotinate in 100 ml. of methanol and 4.6 g. of potassium hydroxide in 10 ml. of water. Reflux the solution for three hours, concentrate in vacuo and dissolve the residue in water. Acidify the aqueous solution to yield the desired 2-(2'-methyl-3'-trifluoromethylanilino) nicotinic acid, m.p. 226°-228° C. after recrystallization from acetone-hexane. By following the teachings of the foregoing examples as well as by the teachings of the above cited reference, there may also be produced the following nicotinic acids:
 

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