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[ CAS No. 5446-17-3 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 5446-17-3
Chemical Structure| 5446-17-3
Structure of 5446-17-3 *Storage: {[proInfo.prStorage]}

Quality Control of [ 5446-17-3 ]

Related Doc. of [ 5446-17-3 ]

SDS

Product Details of [ 5446-17-3 ]

CAS No. :5446-17-3MDL No. :MFCD04038837
Formula : C7H10Cl2N2 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :193.07Pubchem ID :13200574
Synonyms :

Computed Properties of [ 5446-17-3 ]

TPSA : 38 H-Bond Acceptor Count : 2
XLogP3 : - H-Bond Donor Count : 3
SP3 : 0.14 Rotatable Bond Count : 1

Safety of [ 5446-17-3 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5446-17-3 ]

  • Upstream synthesis route of [ 5446-17-3 ]
  • Downstream synthetic route of [ 5446-17-3 ]

[ 5446-17-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 95-79-4 ]
  • [ 5446-17-3 ]
YieldReaction ConditionsOperation in experiment
76%
Stage #1: With hydrogenchloride; sodium nitrite In water at 0℃; for 2.00 h; Inert atmosphere
Stage #2: With tin(II) chloride dihdyrate In water at 0℃; for 0.75 h; Inert atmosphere
To an ice-cooled suspension of 5-chloro-2-methylaniline (1.4362 g, 10.143 mmol, 1.00 equiv) in water (10 mL) was added concentrated hydrochloric acid (10 mL). To this reaction mixture was added dropwise a solution of sodium nitrite (0.791 g, 11.5 mmol, 1.13 equiv) in water (5 mL) at 0° C. After 2 hours, the reaction mixture was slowly added to a stirring ice-cooled solution of tin chloride dihydrate (5.88 g, 25.8 mmol, 2.55 equiv) in concentrated hydrochloric acid (8 mL). Water was added as needed to maintain the stirring while solids formed. The reaction was kept at 0° C. for 45 minutes. The white solids were filtered and rinsed with diethyl ether (2.x.50 mL). The solids were dried under vacuum to provide 1.49 g (76percent) of (5-chloro-2-methylphenyl)hydrazine hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ: 10.08 (s, 3H), 7.98 (s, 1H), 7.13 (d, 1H), 6.97 (s, 1H), 6.91 (d, 1H), 2.14 (s, 3H).
Reference: [1] Patent: US2012/22043, 2012, A1. Location in patent: Page/Page column 84-85
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