[ CAS No. 54509-63-6 ] {[proInfo.proName]}

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• [ 121-43-7 ]
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• [ 54509-63-6 ]
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• [ 156487-13-7 ]

Yield	Reaction Conditions	Operation in experiment
66%	Stage #1: With n-butyllithium In tetrahydrofuran at -70℃; for 2 h; Inert atmosphere Stage #2: at -70 - 20℃; for 16 h; Stage #3: With water In tetrahydrofuran	Preparation of 4-butoxy-3-fluorophenylboronic acid (T-9) The compound (T-8) (97.5 g) obtained in the above procedure was dissolved in dried THF (500 ml) and the solution was cooled to -70 °C. n-BuLi (241 ml) was added dropwise under an atmosphere of nitrogen, and the stirring was continued at -70 °C for another 2 hours. Then, trimethyl borate (62.4 g) in a dried THF solution was added dropwise slowly at -70 °C, and the mixture was warmed up to room temperature. The stirring was continued for another 16 hours. After the completion of the reaction, 2N-HCl (200 ml) was added to the reaction mixture. The mixture was extracted with toluene, and the organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to leave pale brown solids. Recrystallization (heptane:toluene= 4:1 by volume) gave the compound (T-9) as colorless powders (54.8 g) in 66percent yield.