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Chemical Structure| 54527-65-0 Chemical Structure| 54527-65-0

Structure of 54527-65-0

Chemical Structure| 54527-65-0

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Product Details of [ 54527-65-0 ]

CAS No. :54527-65-0
Formula : C14H19NO3
M.W : 249.31
SMILES Code : CC(CC(OCCN(C)CC1=CC=CC=C1)=O)=O
MDL No. :MFCD00071539

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Application In Synthesis of [ 54527-65-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54527-65-0 ]

[ 54527-65-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 54527-65-0 ]
  • [ 96516-29-9 ]
  • [ 14205-39-1 ]
  • 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-fluoro-3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate [ No CAS ]
  • 2
  • [ 54527-65-0 ]
  • [ 21731-17-9 ]
  • [ 96516-29-9 ]
  • 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-fluoro-3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
In isopropyl alcohol; EXAMPLE 3 Synthesis of 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-fluoro-3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (104) A mixture of 330 mg of <strong>[96516-29-9]2-fluoro-3-nitrobenzaldehyde</strong>, 252 mg of methyl 3-aminocrotonate and 506 mg of 2-(N-benzyl-N-methylamino)ethyl acetoacetate in 2 ml of 2-propanol was refluxed for 12 hours, and then the solvent was distilled off in vacuo. The residue was purified by the method of a column chromatography on silica gel to provide 492 mg of the desired compound (104). IR (CHCl3) numaxcm-1: 1692, 1614, 1462 NMR (CDCl3) deltappm: 7.94-7.55 (m, 2H), 7.27 (s, 5H), 7.06 (m, 1H), 5.83 (brs, 1H), 5.31 (s, 1H), 4.13 (t, 2H, J=6 Hz), 3.59 (s, 3H), 3.48 (s, 2H), 2.60 (t, 2H, J=6 Hz), 2.30 (s, 6H), 2.15 (s, 3H)
 

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