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Chemical Structure| 5467-79-8 Chemical Structure| 5467-79-8

Structure of 5467-79-8

Chemical Structure| 5467-79-8

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Product Details of [ 5467-79-8 ]

CAS No. :5467-79-8
Formula : C11H8N2O
M.W : 184.19
SMILES Code : N#CC1=NC2=CC=C(OC)C=C2C=C1
MDL No. :MFCD00023938

Safety of [ 5467-79-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H318
Precautionary Statements:P280-P301+P312+P330-P305+P351+P338+P310
Class:9
UN#:3077
Packing Group:

Application In Synthesis of [ 5467-79-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5467-79-8 ]

[ 5467-79-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6563-13-9 ]
  • [ 506-64-9 ]
  • [ 5467-79-8 ]
YieldReaction ConditionsOperation in experiment
82% With benzoyl chloride; In chloroform; at 20℃; for 18h;Heating / reflux; 6-Methoxy-quinoline-1-oxide (13.48 g, 0.076 mol) in 30 ml chloroform was treated with 3.87 g (0.028 mol) of benzoyl chloride and 3.65 g (0.0 27 mol) of silver cyanide. The mixture was stirred for 4 hours at room temperature and stirred to reflux for additional 14 h. After evaporation of the solvent to half volume the mixture was cooled to 0 C. and a precipitate of silver salt appeared. The mixture was filtered and the solution was concentrated and the solid residue was washed in diethyl ether and dried under vacuum to yield 11 g (82%) of the title compound as light brown solid. MS (m/e)=185.3 (M+H)+.
  • 2
  • [ 6563-13-9 ]
  • [ 7677-24-9 ]
  • [ 5467-79-8 ]
YieldReaction ConditionsOperation in experiment
92% With tetrachloromethane; potassium carbonate; phosphonic acid diethyl ester; In dimethyl sulfoxide; at 20℃; for 4h; 6-methyl-quinoline-N-oxide (0.175 g, 1 mmol), trimethyl cyanosilane (0.119 g, 1.2 mmol), diethyl H-phosphite (0.276 g, 2 mmol), carbon tetrachloride (0.308g, 2mmol), K2CO3(0.276g, 2mmol), 10mL of DMSO in a 50mL three-necked flask, and reacted at room temperature for 4h. After the reaction was completed, 20ml of water was added and extracted with dichloromethane. The organic phases were combined, dried, filtered, and the solvent was removed under reduced pressure. Column chromatography (petroleum ether / ethyl acetate, V / V = 5: 1), the target compound was obtained as a white powder, with a yield of 92%, and the structural formula was as follows:
 

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