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[ CAS No. 54705-91-8 ]

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Chemical Structure| 54705-91-8
Chemical Structure| 54705-91-8
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CAS No. :54705-91-8 MDL No. :MFCD03086227
Formula : C9H9N3 Boiling Point : 305.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :159.19 g/mol Pubchem ID :-
Synonyms :

Safety of [ 54705-91-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 54705-91-8 ]

  • Downstream synthetic route of [ 54705-91-8 ]

[ 54705-91-8 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 25688-17-9 ]
  • [ 54705-91-8 ]
YieldReaction ConditionsOperation in experiment
96% With hydrogen In ethanol for 3h; Ambient temperature;
95% With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; Inert atmosphere;
95% With palladium on activated carbon; hydrogen In ethanol
93% With hydrazine hydrate In ethanol for 1h; Heating;
87% With hydrazine hydrate In methanol for 4h; Heating;
74% With hydrogen In ethanol
With palladium on activated charcoal; hydrazine hydrate In ethanol for 8h; Reflux; Heating; 3.2.2. Synthesis of 2-(Benzo[d]thiazol-2-yl)anilines 2 and 8a-8m General procedure: In a 100 mL three-necked flask equipped with a dropping funnel, 2-(2-nitrophenyl)benzo[d]- thiazole (1, 3.0 g, 12.5 mmol) and ethanol (50 mL) were mixed and heated to reflux. Palladized charcoal (0.1 g, 5%) was added, then 80% hydrazine hydrate solution (10 mL) was added from a dropping funnel during 30 min [10,11]. The heating was continued for 8 h and then the mixture cooled. The solid was filtered off and the filtrate was concentrated to give a crude product that was recrystallized from ethyl acetate and petroleum ether solution (1:5) to afford compound 2 as a yellow powder (yield: 3.76 g, 85%).
With iron; ammonium chloride In ethanol; water at 80℃;

  • 2
  • [ 7476-66-6 ]
  • [ 54705-91-8 ]
  • Phenyl-(2-pyrazol-1-yl-phenylamino)-acetic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium acetate In ethanol at 130℃; for 40h; Yield given;
  • 3
  • [ 288-13-1 ]
  • [ 615-36-1 ]
  • [ 54705-91-8 ]
YieldReaction ConditionsOperation in experiment
90% With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine In toluene at 110℃; for 24h;
85% With potassium phosphate; benzoin oxime; copper diacetate In dimethyl sulfoxide at 80℃; Inert atmosphere; General Procedure for Catalytic Experiments General procedure: K3PO4 (5.62 mmol) in DMSO (4 mL), were added Cu(OAc)2 (0.28 mmol). The flask was evacuatedand backfilled with argon for three times. The resulting suspension was heated in a 80 °C oil bathwith stirring for the indicated time. The reactor was cooled to r.t., the flask was opened to air and thereaction mixture was poured into water (20 mL), extracted with ethyl acetate (20 mL × 3), andorganic layer was washed with water (20 mL × 2) and once with brine (25 mL), dried overmagnesium sulfate and concentrated in vacuo. The product was purified by column chromatographyon silica gel using petroleum ether and ethyl acetate as eluent.1-(2-Methoxyphenyl)-1H-pyrrole (3a) [30]: colorless oil (0.43 g, 88%). 1H-NMR (400 MHz, CDCl3) δ (ppm):7.30-7.23 (2H, m), 7.03-6.98 (4H, m), 6.30 (2H,
82% With quebrachitol; copper; caesium carbonate In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere; Green chemistry;
77% With potassium carbonate; N,N`-dimethylethylenediamine In xylene for 36h; Heating;

  • 4
  • [ 400743-82-0 ]
  • [ 20012-63-9 ]
  • [ 39643-31-7 ]
  • [ 728918-72-7 ]
  • C8H7F4N [ No CAS ]
  • C33H29IN5O4Pol [ No CAS ]
  • [ 91646-45-6 ]
  • [ 4273-98-7 ]
  • [ 2264-92-8 ]
  • [ 1204-44-0 ]
  • [ 68817-71-0 ]
  • [ 369-36-8 ]
  • [ 37750-29-1 ]
  • [ 55751-54-7 ]
  • [ 18595-14-7 ]
  • [ 52562-19-3 ]
  • [ 62532-99-4 ]
  • [ 21627-58-7 ]
  • [ 73818-73-2 ]
  • [ 54705-91-8 ]
  • [ 26286-54-4 ]
  • [ 177171-13-0 ]
  • [ 99-55-8 ]
  • [ 23491-48-7 ]
  • [ 400750-84-7 ]
  • C42H37N8O4Pol [ No CAS ]
  • C42H37N8O4Pol [ No CAS ]
  • C43H43N6O4Pol [ No CAS ]
  • C42H39N6O4Pol [ No CAS ]
  • C43H37N6O4PolS [ No CAS ]
  • C40H36N7O6Pol [ No CAS ]
  • C42H39N6O6Pol [ No CAS ]
  • C39H33FN7O6Pol [ No CAS ]
  • C44H39N6O5Pol [ No CAS ]
  • C45H38ClN6O4Pol [ No CAS ]
  • C46H41N6O4Pol [ No CAS ]
  • C43H42N7O4Pol [ No CAS ]
  • C46H41N6O5Pol [ No CAS ]
  • C45H38FN6O4Pol [ No CAS ]
  • C45H38ClN6O4Pol [ No CAS ]
  • C41H35F4N6O4Pol [ No CAS ]
  • C45H39N6O6PolS [ No CAS ]
  • C45H38ClN6O4PolS [ No CAS ]
  • C44H44N7O4Pol [ No CAS ]
  • C47H41N6O5Pol [ No CAS ]
  • C45H39ClN7O4Pol [ No CAS ]
  • C47H41N6O6Pol [ No CAS ]
  • C45H45N8O5Pol [ No CAS ]
  • C44H44N9O6Pol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ISOPROPYLAMIDE; at 60℃;Combinatorial reaction / High throughput screening (HTS); Step 2. Catalytic amination of the solid supported 8-iodo-l-methyl-4,5-dihydro- lH-pyrazolo [4,3-h] quinazoline-3-carboxamide; <n="82"/>Using a 4 niL Argonaut Trident synthesizer cassette, 200 mg (0.11 mmol) of the resin from step 1 above, were charged into separate vials. To each of the reactor vials flushed with argon, finely divided potassium carbonate (0.15 g, 1.1 mmol), palladium acetate [Pd(OAc)2] (2.5mg, 0.011 mmol, 10%), (HK)-BINAP (6.8 mg, 0.011 mmol, 10%) and the corresponding amine (0.22 mmol, 2 equivalents) in degassed (argon) dimethyacetamide (2 mL) were added. The resulting mixture was agitated at 600C for 10 hours on the Argonaut Trident Automated Library Synthesizer (ALS) station. The Trident ALS station was programmed to continuously mechanically agitate the resin at 6O0C while a nitrogen gas "sparge" was incorporated to re-suspend the scarcely soluble potassium carbonate. Nitrogen gas sparging was incorporated once per hour, for a 30 second duration, throughout the 16-hour heating cycle.The resin was drained from the synthesis cocktail and washed using the Argonaut Trident External Agitation Thermal Unit (EATU) synthesis station with DMA (3 x 2 mL, 5 min.). The above catalytic amination cycle was repeated a second time using the previously described procedure.Upon completion of the second amination cycle, the resin was drained from the synthesis cocktail and washed using the Argonaut Trident EATU synthesis station with DMF (1 x 2 mL, 5 min.), with water (1 x 2 mL, 5 min.), with DMF/water (1 : 1) (3 x 2 mL, 5 min.), with DMF (3 x 2 mL, 5 min.), with methanol (3 x 2 mL, 5 min.) and with DCM (3 x 2 mL, 5 min.).
  • 5
  • [ 33775-94-9 ]
  • [ 54705-91-8 ]
  • [ 1202706-29-3 ]
YieldReaction ConditionsOperation in experiment
86% With potassium phosphate; copper(l) iodide; <i>L</i>-proline In toluene at 20 - 110℃; Inert atmosphere;
  • 6
  • [ 98-59-9 ]
  • [ 54705-91-8 ]
  • [ 1379667-34-1 ]
  • C23H21N3O4S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
1: 67% 2: 7% With triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere; 4.6. HNSO2PhMePzH To a flask containing 1-(2-aminophenyl)pyrazole (0.796g, 5.0mmol) and toluenesulfonyl chloride (1.05g, 5.5mmol), 30mL dichloromethane were added at room temperature. To this reaction mixture, NEt3 (0.765mL, 5.5mmol) was added via syringe at 0°C. After one hour of stirring, all the volatiles were pumped off. The residue was extracted with toluene (5mL×3). Crude product was purified by column chromatography (hexane/ethyl acetate 3:1). The second band was collected to afford pale-white solid (1.05g, 67.0%). The third band was collected to afford di-substituted side product, PzHN(SO2PhMe)2, as white solid (0.165g, 7.0%). Data for HNSO2PhMePzH: Anal. Calc. for C16H15N3O2S: C, 61.32; H, 4.82; N, 13.41. Found: C, 61.60; H, 5.08; N, 13.50. 1H NMR (400MHz, CDCl3): δ (ppm) 10.04 (br, 1H, -NH), 7.73-7.77 (overlap, 2H, C6H5), 7.26-7.34 (overlap, 4H, C6H5), 7.14-7.20 (overlap, 2H, C6H5), 7.01 (d, J=8.4Hz, 2H, C6H5), 6.36 (m, 1H, C6H5), 2.30 (s, 3H, -CH3). 13C NMR (100MHz, CDCl3): δ (ppm) 143.1, 135.7, 131.0, 129.8 (Cipso-C6H5), 140.8, 129.2, 129.1, 127.6, 126.3, 125.8, 125.2, 121.6, 107.1 (CH-C6H5), 21.2 (-CH3). Data for PzHN(SO2PhMe)2: Anal. Calc. for C23H21N3O4S2: C, 59.08; H, 4.53; N, 8.99. Found: C, 59.05; H, 4.73; N, 8.40. 1H NMR (400MHz, CDCl3): δ (ppm) 8.20 (m, 1H, C6H5), 7.71 (d, J=8.4Hz, 4H, C6H5), 7.67 (dd, J=8.0 & 1.6Hz, 1H, C6H5), 7.52-7.58 (overlap, 2H, C6H5), 7.31 (m, 2H, C6H5), 7.26 (dd, J=8.0 & 0.4Hz, 4H, C6H5), 6.96 (d, J=8.4Hz, 1H, C6H5), 6.13 (m, 1H, C6H5), 2.46 (s, 6H, -CH3). 13C NMR (100MHz, CDCl3): δ (ppm) 145.1, 140.7, 135.9, 131.3 (Cipso-C6H5), 141.0, 132.6, 131.5, 129.3, 129.2, 127.9, 127.7, 107.3 (CH-C6H5), 21.6 (-CH3) [51].
  • 7
  • [ 773-64-8 ]
  • [ 54705-91-8 ]
  • [ 1388180-51-5 ]
YieldReaction ConditionsOperation in experiment
56% With triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere; 4.6. HNSO2PhMePzH General procedure: The procedure for the preparation of HNSO2PhTriMePzH was similar to that used for HNSO2PhMePzH but with 2-mesitylenesulfonyl chloride (1.20g, 5.5mmol) and 20mL dichloromethane. The second band was collected to afford white solid (0.96g, 56.0%). Anal. Calc. for C18H19N3O2S: C, 63.32; H, 5.61; N, 12.31. Found: C, 63.18; H, 5.49; N, 12.53. 1H NMR (400MHz, CDCl3): δ (ppm) 9.97 (br, 1H, -NH), 7.75 (d, J=1.2Hz, 1H, C6H5), 7.55 (dd, J=8.0 & 1.2Hz, 1H, C6H5), 7.51 (dd, J=2.4 & 0.4Hz, 1H, C6H5), 7.19-7.26 (overlap, 2H, C6H5), 7.13 (m, 1H, C6H5), 6.79 (br, 2H, C6H5), 6.40 (m, 1H, C6H5), 2.41 (s, 6H, o-CH3-Ph), 2.22 (s, 3H, p-CH3-Ph). 13C NMR (100MHz, CDCl3): δ (ppm) 142.1, 138.8, 133.4, 130.2, 130.1 (Cipso-C6H5), 141.0, 132.6, 131.5, 129.3, 129.2, 127.9, 127.7, 107.3 (CH-C6H5), 21.6 (-CH3).
  • 8
  • [ 349-88-2 ]
  • [ 54705-91-8 ]
  • [ 1542317-50-9 ]
YieldReaction ConditionsOperation in experiment
75% With triethylamine In tetrahydrofuran at 0 - 50℃; for 1h; Inert atmosphere; 4.9. PzHN(SO2PhF)2 To a flask containing 1-(2-aminophenyl)pyrazole (0.159g, 1.0mmol) and 4-fluorobenzene-sulfonyl chloride (0.428g, 1.0mmol), 30mL THF were added at room temperature. To this reaction mixture, NEt3 (0.31mL, 2.2mmol) was added via syringe at 0°C. The reaction mixture was warmed up to 50°C. After one hour of stirring, all the volatiles were pumped off. The residue was extracted with toluene (5mL×3). Crude product was purified by column chromatography (hexane/ethyl acetate 3:1). The second band was collected to afford white solid (0.357g, 75.0%). 1H NMR (400MHz, CDCl3): δ (ppm) 8.12 (m, 1H, C6H5), 7.87-7.90 (overlap, 4H, C6H5), 7.57-7.66 (overlap, 2H, C6H5), 7.51 (d, J=1.6Hz, 1H, C6H5), 7.35 (m, 1H, C6H5), 7.14-7.18 (overlap, 4H, C6H5), 6.97 (dd, J=8.0 & 1.6Hz, 1H, C6H5), 6.16 (m, 1H, C6H5). 13C NMR (100MHz, CDCl3): δ (ppm) 167.2, 164.6, 140.6, 134.6, 127.7 (Cipso-C6H5), 141.3, 132.5, 132.3, 132.2, 131.7, 131.4, 128.2, 128.0, 116.2, 116.0, 107.5 (CH-C6H5).
  • 9
  • [ 288-13-1 ]
  • [ 615-43-0 ]
  • [ 54705-91-8 ]
YieldReaction ConditionsOperation in experiment
74% With copper diacetate; sodium hydroxide; 3-(diphenylphosphino)propionic acid In 1,4-dioxane at 100℃; for 24h; Sealed tube; Procedure for N-arylation of 1H-pyrazole: General procedure: Cu(OAc)2 (0.03mmol), L2 (0.06mmol), aryl idione or bromide (0.5mmol), 1H-pyrazole (0.75mmol), NaOH (1mmol), and 1,4-dioxane (1mL) was added into a 5mL tube, then sealed. The mixture was stirred at 100°C for certain time. After cooling to room temperature, the mixture was quenched with 10mL H2O and extracted with EtOAc (3×20mL). The combined EtOAc extracts were dried with anhydrous Na2SO4 and filtrated and the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel with PE/EtOAc, as the eluent, to afford the desired products.
  • 10
  • [ 124-38-9 ]
  • [ 54705-91-8 ]
  • [ 114722-60-0 ]
YieldReaction ConditionsOperation in experiment
40% With sodium t-butanolate In diethylene glycol dimethyl ether at 140℃; for 24h; Glovebox; Schlenk technique;
  • 11
  • N-(2-(1H-pyrazol-1-yl)phenyl)benzamide [ No CAS ]
  • [ 162787-61-3 ]
  • [ 54705-91-8 ]
  • 12
  • N-(2-(1H-pyrazol-1-yl)phenyl)-2-(methylsulfonamido)benzamide [ No CAS ]
  • [ 162787-61-3 ]
  • [ 54705-91-8 ]
  • 13
  • N-(2-(1H-pyrazol-1-yl)phenyl)-4-methylbenzamide [ No CAS ]
  • [ 81245-24-1 ]
  • [ 54705-91-8 ]
  • 14
  • C18H17N3O2 [ No CAS ]
  • [ 81245-24-1 ]
  • [ 54705-91-8 ]
  • 15
  • [ 1147550-11-5 ]
  • [ 54705-91-8 ]
  • 2-(1,2-pyrazol-1-yl)-4-thiocyanatoaniline [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With N,N,N-trimethylbenzenemethanaminium dichloroiodate In lithium hydroxide monohydrate; dimethyl sulfoxide at 70℃; for 1h; General Procedure General procedure: To a stirred solution of anilines 14a-g' or other substrates (20a-d; 22a-b) (0.27-0.47 mmol), ammonium thiocyanate (1.1 equiv) in 9:1 DMSO:H2O (3.4-6.0 mL; 80 mM final concentration), was added benzyltrimethylammonium dichloroiodate (1.2 equiv). The reaction mixture was heated at 70°C for 1 hour, then allowed to cool to ambient temperature. H2O (25 mL) was added. The mixture was diluted using ethyl acetate, and the organic layer was separated. The aqueous layer was partitioned with EtOAc (2 x 20 mL) and the combined organic layers were washed with 10% aqueous sodium dithionite (2 x 20 mL), followed by saturated sodium bicarbonate solution (2 x 20 mL) and then water (2 X 20 mL). The organic layer was dried over anhydrous magnesium sulfate and the solvents were evaporated. The crude product was then purified using flash chromatography (EtOAc/Hexanes) to give pure 15a-g', 21a-d, and 23a-b.
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