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Chemical Structure| 54737-66-5 Chemical Structure| 54737-66-5

Structure of 54737-66-5

Chemical Structure| 54737-66-5

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Product Details of [ 54737-66-5 ]

CAS No. :54737-66-5
Formula : C15H17NO
M.W : 227.30
SMILES Code : CC(N)(C1=CC=C(OC2=CC=CC=C2)C=C1)C
MDL No. :MFCD19696474
InChI Key :YLAODKGKGJCBKP-UHFFFAOYSA-N
Pubchem ID :15754154

Safety of [ 54737-66-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 54737-66-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54737-66-5 ]

[ 54737-66-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3096-81-9 ]
  • [ 917-54-4 ]
  • [ 54737-66-5 ]
YieldReaction ConditionsOperation in experiment
31% After 15 minutes of stirring the grey suspension was cooled to -78 C. and MeLi (6.0 mL, 9.31 mmol, 6.0 eq.) was added drop wise over the course of 10 minutes. After 30 minutes a solution of <strong>[3096-81-9]4-phenoxybenzonitrile</strong> (0.3 g, 1.5 mmol, 1.0 eq.) in 2 mL THF was added drop wise to the reaction mixture. After 15 minutes of stirring the reaction mixture was allowed to warm to room temperature and was stirred for an hour. The solution was again cooled to -78 C. and aqueous NH4OH (6 mL) was added. The mixture was allowed to warm to room temperature overnight. The reaction mixture was decanted and the residue was extracted with THF. Organic fractions were combined and all volatiles were evaporated. The resulting yellow oil was dissolved in DCM, extracted with brine (20 mL), dried over Mg2SO4 and all volatiles were evaporated affording a product which was used without further purification (0.11 g, 31%). LCMS: 211.0 [M-NH3]+.
 

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