Alternatived Products of [ 55496-54-3 ]
Product Details of [ 55496-54-3 ]
CAS No. : | 55496-54-3 |
MDL No. : | MFCD08458276 |
Formula : |
C11H11ClN2O3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
254.67
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 55496-54-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 55496-54-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 55496-54-3 ]
- 1
-
[ 41825-73-4 ]
-
[ 55496-54-3 ]
-
[ 1173284-34-8 ]
Yield | Reaction Conditions | Operation in experiment |
83.2% |
In isopropyl alcohol at 80℃; for 0.5h; Microwave irradiation; |
4.2.6. General procedure for the synthesis of 5,6,7-trimethoxy-Naryl-4-aminoquinazolines (6a-6z)
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 °C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
Reference:
[1]Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song
[European Journal of Medicinal Chemistry, 2013, vol. 66, p. 335 - 344]
- 2
-
[ 38762-41-3 ]
-
[ 55496-54-3 ]
-
[ 1173284-30-4 ]
Yield | Reaction Conditions | Operation in experiment |
81.0% |
In isopropyl alcohol; at 80℃; for 0.5h;Microwave irradiation; |
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
- 3
-
[ 1003-99-2 ]
-
[ 55496-54-3 ]
-
[ 1173284-35-9 ]
Yield | Reaction Conditions | Operation in experiment |
80.1% |
In isopropyl alcohol at 80℃; for 0.5h; Microwave irradiation; |
4.2.6. General procedure for the synthesis of 5,6,7-trimethoxy-Naryl-4-aminoquinazolines (6a-6z)
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 °C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
Reference:
[1]Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song
[European Journal of Medicinal Chemistry, 2013, vol. 66, p. 335 - 344]
- 4
-
[ 535-52-4 ]
-
[ 55496-54-3 ]
-
[ 1173284-32-6 ]
Yield | Reaction Conditions | Operation in experiment |
80.7% |
In isopropyl alcohol; at 80℃; for 0.5h;Microwave irradiation; |
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
- 5
-
[ 454-79-5 ]
-
[ 55496-54-3 ]
-
[ 1173284-37-1 ]
Yield | Reaction Conditions | Operation in experiment |
83.6% |
In isopropyl alcohol at 80℃; for 0.5h; Microwave irradiation; |
4.2.6. General procedure for the synthesis of 5,6,7-trimethoxy-Naryl-4-aminoquinazolines (6a-6z)
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 °C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
Reference:
[1]Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song
[European Journal of Medicinal Chemistry, 2013, vol. 66, p. 335 - 344]
- 6
-
[ 123973-25-1 ]
-
[ 55496-54-3 ]
-
[ 1449276-37-2 ]
Yield | Reaction Conditions | Operation in experiment |
81.2% |
In isopropyl alcohol at 80℃; for 0.5h; Microwave irradiation; |
4.2.6. General procedure for the synthesis of 5,6,7-trimethoxy-Naryl-4-aminoquinazolines (6a-6z)
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 °C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
Reference:
[1]Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song
[European Journal of Medicinal Chemistry, 2013, vol. 66, p. 335 - 344]
- 7
-
[ 444-14-4 ]
-
[ 55496-54-3 ]
-
[ 1449276-38-3 ]
Yield | Reaction Conditions | Operation in experiment |
84.8% |
In isopropyl alcohol; at 80℃; for 0.5h;Microwave irradiation; |
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
- 8
-
[ 20776-54-9 ]
-
[ 55496-54-3 ]
-
[ 1449276-39-4 ]
Yield | Reaction Conditions | Operation in experiment |
80.5% |
In isopropyl alcohol; at 80℃; for 0.5h;Microwave irradiation; |
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
- 9
-
[ 52721-69-4 ]
-
[ 55496-54-3 ]
-
[ 1449276-40-7 ]
Yield | Reaction Conditions | Operation in experiment |
83.9% |
In isopropyl alcohol; at 80℃; for 0.5h;Microwave irradiation; |
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
- 10
-
[ 55496-54-3 ]
-
[ 5653-40-7 ]
-
[ 1449276-41-8 ]
Yield | Reaction Conditions | Operation in experiment |
85.4% |
In isopropyl alcohol at 80℃; for 0.5h; Microwave irradiation; |
4.2.6. General procedure for the synthesis of 5,6,7-trimethoxy-Naryl-4-aminoquinazolines (6a-6z)
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 °C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |
Reference:
[1]Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song
[European Journal of Medicinal Chemistry, 2013, vol. 66, p. 335 - 344]
- 11
-
[ 404-70-6 ]
-
[ 55496-54-3 ]
-
[ 1449276-42-9 ]
Yield | Reaction Conditions | Operation in experiment |
83.7% |
In isopropyl alcohol; at 80℃; for 0.5h;Microwave irradiation; |
General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds. |