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Chemical Structure| 55539-83-8 Chemical Structure| 55539-83-8

Structure of 55539-83-8

Chemical Structure| 55539-83-8

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Product Details of [ 55539-83-8 ]

CAS No. :55539-83-8
Formula : C11H11NO
M.W : 173.21
SMILES Code : O=C1N(C2=C(C=C1C)C=CC=C2)C
MDL No. :MFCD29052058

Safety of [ 55539-83-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 55539-83-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55539-83-8 ]

[ 55539-83-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 55539-83-8 ]
  • [ 57876-69-4 ]
YieldReaction ConditionsOperation in experiment
54% With trichloroisocyanuric acid; triphenylphosphine; In neat (no solvent); at 160 - 170℃; for 17h;Inert atmosphere; General procedure: Ina flask (50 mL) equipped with a magnetic stirrer bar and balloon, a mixture of triphenylphosphine (1191mg, 4.54 mmol) and trichloroisocyanuric acid (360 mg, 1.55 mmol) was heated under an argonatmosphere. During the heating process, triphenylphosphine melted, and trichloroisocyanuric acidvigorously reacted at 130-140 C to form a dark brown oil, followed by further heating for 10 min.1-Methylquinolin-2(1H)-one (242 mg, 1.50 mmol) was added to the mixture followed by heating at130-140 C for 3 h. Then, the reaction mixture was dissolved in CH2Cl2 and basified with triethylaminefollowed by silica gel column chromatography using hexane-EtOAc (6:1) as an eluate. The product2-chloroquinoline (204 mg, 82%) was obtained.
 

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