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[ CAS No. 5556-20-7 ]

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Chemical Structure| 5556-20-7
Chemical Structure| 5556-20-7
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Product Details of [ 5556-20-7 ]

CAS No. :5556-20-7 MDL No. :MFCD09753998
Formula : C11H10O3S Boiling Point : 344.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :222.26 g/mol Pubchem ID :54678584
Synonyms :

Safety of [ 5556-20-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5556-20-7 ]

  • Upstream synthesis route of [ 5556-20-7 ]
  • Downstream synthetic route of [ 5556-20-7 ]

[ 5556-20-7 ] Synthesis Path-Upstream   1~19

  • 1
  • [ 4892-02-8 ]
  • [ 5556-20-7 ]
YieldReaction ConditionsOperation in experiment
88% With potassium <i>tert</i>-butylate In tetrahydrofuran at 20℃; for 0.283333 h; Inert atmosphere Intermediate 6: Ethyl-3-hydroxybenzo[6]thiophene-2-carboxylate To a solution of methyl-2-mercaptobenzoate (1.63 mL, 1 1.9 mmol) and ethyl bromoacetate (1.32 mL, 1 1.9 mmol) in dry tetrahydrofuran (130 mL) at 0 °C was added potassium fert-butoxide (5.14 g, 71.3 mmol) gradually over 2 min. The reaction mixture was stirred and allowed to warm to room temperature over 15 min, quenched with 2 M hydrochloric acid to pH 2 and diluted with 75 mL water. The product was immediately extracted with 3 χ 75 mL portions of ethyl acetate. The organic layers were combined, washed with 75 mL brine, dried over magnesium sulfate and concentrated under reduced pressure to give desired product as a yellow solid (2.32 g, 88percent). 3) 10.21 (IH, s), 7.94 (IH), 7.74 (IH), 7.50 (IH), 7.41 (IH), 4.43 (2H), 1.43 (3H).
Reference: [1] Patent: WO2013/83991, 2013, A1, . Location in patent: Page/Page column 68
  • 2
  • [ 19602-82-5 ]
  • [ 105-53-3 ]
  • [ 5556-20-7 ]
Reference: [1] Chemical Communications, 2009, # 46, p. 7131 - 7133
  • 3
  • [ 19602-82-5 ]
  • [ 141-97-9 ]
  • [ 5556-20-7 ]
Reference: [1] Chemical Communications, 2009, # 46, p. 7131 - 7133
  • 4
  • [ 105-36-2 ]
  • [ 4892-02-8 ]
  • [ 5556-20-7 ]
Reference: [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1959 - 1970
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 1, p. 371 - 375
  • 5
  • [ 19602-82-5 ]
  • [ 141-97-9 ]
  • [ 5556-20-7 ]
  • [ 131327-65-6 ]
Reference: [1] Chemical Communications, 2009, # 46, p. 7131 - 7133
  • 6
  • [ 3950-02-5 ]
  • [ 141-97-9 ]
  • [ 5556-20-7 ]
Reference: [1] Phosphorus, Sulfur and Silicon and the Related Elements, 2009, vol. 184, # 5, p. 1115 - 1123
  • 7
  • [ 3950-02-5 ]
  • [ 105-53-3 ]
  • [ 5556-20-7 ]
  • [ 1190582-63-8 ]
Reference: [1] Phosphorus, Sulfur and Silicon and the Related Elements, 2009, vol. 184, # 5, p. 1115 - 1123
  • 8
  • [ 36943-39-2 ]
  • [ 5556-20-7 ]
Reference: [1] Tetrahedron, 1990, vol. 46, # 18, p. 6525 - 6544
  • 9
  • [ 131327-55-4 ]
  • [ 5556-20-7 ]
Reference: [1] Tetrahedron, 1990, vol. 46, # 18, p. 6525 - 6544
  • 10
  • [ 131327-52-1 ]
  • [ 5556-20-7 ]
Reference: [1] Tetrahedron, 1990, vol. 46, # 18, p. 6525 - 6544
  • 11
  • [ 3950-02-5 ]
  • [ 94-02-0 ]
  • [ 5556-20-7 ]
  • [ 1190582-62-7 ]
Reference: [1] Phosphorus, Sulfur and Silicon and the Related Elements, 2009, vol. 184, # 5, p. 1115 - 1123
  • 12
  • [ 52140-90-6 ]
  • [ 5556-20-7 ]
  • [ 53599-13-6 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1985, vol. 22, # 1, p. 89 - 92
  • 13
  • [ 1190582-62-7 ]
  • [ 5556-20-7 ]
Reference: [1] Phosphorus, Sulfur and Silicon and the Related Elements, 2009, vol. 184, # 5, p. 1115 - 1123
  • 14
  • [ 52140-90-6 ]
  • [ 64-17-5 ]
  • [ 5556-20-7 ]
  • [ 53599-13-6 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1985, vol. 22, # 1, p. 89 - 92
  • 15
  • [ 120571-33-7 ]
  • [ 5556-20-7 ]
Reference: [1] Tetrahedron, 1990, vol. 46, # 18, p. 6525 - 6544
  • 16
  • [ 120571-35-9 ]
  • [ 5556-20-7 ]
Reference: [1] Tetrahedron, 1990, vol. 46, # 18, p. 6525 - 6544
  • 17
  • [ 19602-82-5 ]
  • [ 1007476-32-5 ]
  • [ 5556-20-7 ]
Reference: [1] Chemische Berichte, 1926, vol. 59, p. 1078
  • 18
  • [ 17927-88-7 ]
  • [ 141-97-9 ]
  • [ 5556-20-7 ]
Reference: [1] Journal of the Chemical Society, 1947, p. 1574,1576
  • 19
  • [ 17927-88-7 ]
  • [ 105-53-3 ]
  • [ 5556-20-7 ]
Reference: [1] Journal of the Chemical Society, 1947, p. 1574,1576
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