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Chemical Structure| 55881-33-9 Chemical Structure| 55881-33-9

Structure of 55881-33-9

Chemical Structure| 55881-33-9

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Product Details of [ 55881-33-9 ]

CAS No. :55881-33-9
Formula : C6H10N4O2
M.W : 170.17
SMILES Code : O=[N+](C1=CN=C(C)N1CCN)[O-]
MDL No. :MFCD07190072

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Application In Synthesis of [ 55881-33-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55881-33-9 ]

[ 55881-33-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3034-48-8 ]
  • [ 55881-33-9 ]
  • N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5-nitrothiazol-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
25% With potassium carbonate; In N,N-dimethyl-formamide; at 70℃;Inert atmosphere; A mixture of 0.17 g 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanamine (16, 1.0 mmol), 0.21 g <strong>[3034-48-8]<strong>[3034-48-8]2-bromo-5-nitrothiazol</strong>e</strong> (12, 1.0 mmol), and 0.14 g potassium carbonate anhydrous (1.0 mmol) was dissolved in dry DMF and stirred at 70 °C overnight under nitrogen. The mixture was then cooled to room temperature, treated with 50 cm3 water, and extracted with ethyl acetate (5 9 50 cm3). The solvent was removed under reduced pressure and the residue was purified by preparative silica gel plates using ethyl acetate to give pure 22. Yield: 0.075 g (25 percent); m.p.:204-207 °C; 1H NMR (500 MHz, DMSO-d6): d = 1.24 (s,3H, CH3), 3.85 (m, 2H, H20), 4.51 (m, 2H, H30), 8.02 (s,1H, H400), 8.22 (s, 1H, H4), 9.50 (s, 1H, NH10) ppm; 13CNMR (125 MHz, DMSO-d6): d = 14.3 (C-200-CH3), 45.5(C-20 ? C-30), 133.6 (C-4 ? C-400), 136.1 (C-5), 139.1 (C-500), 147.1 (C-200), 151.8 (C-2) ppm; HRMS (ESI): m/z calcd for C9H11N6O4S [M? H]? 299.05625, found299.05570
 

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