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Chemical Structure| 56239-25-9 Chemical Structure| 56239-25-9

Structure of 56239-25-9

Chemical Structure| 56239-25-9

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Product Details of [ 56239-25-9 ]

CAS No. :56239-25-9
Formula : C6H10ClNO
M.W : 147.60
SMILES Code : [H]Cl.C1(CC2)NOC2C=C1
MDL No. :MFCD13186016

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Application In Synthesis of [ 56239-25-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56239-25-9 ]

[ 56239-25-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 56239-25-9 ]
  • [ 56239-26-0 ]
YieldReaction ConditionsOperation in experiment
To a solution of 30.0 g (0.265 mol) of cyclohexanone oxime in 300 ml of methylene chloride and 38 ml of ethanol was slowly added at 0 0C 34.5 g (0.318 mol) of tert- butyl-hypochlorite. The resulting dark blue solution was cooled to -2O0C and then 31.9 g (0.398 mol) of 1 ,3-cyclohexadiene were added and the mixture was stored in a freezer at 5°C for 2 days until the blue color had disappeared. The reaction mixture was concentrated to 50percent of its volume and then 600 ml of diethyl ether were slowly added. After stirring overnight the resulting precipitate was isolated by suction to yield 29,0 g of 2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene hydrochloride. 5.0 g (0.045 mol) of this material were hydrogenated with 3.0 g (0.013 mol) platinum oxide at 2 bar hydrogen pressure. After 7 h the catalyst was filtered off and a solution of 20 ml 4 M hydrochloric acid in dioxane was added. After evaporation the residue was recrystallized from 30 ml isopropanol giving 3.1 g of cis-4-aminocyclohexanol hydrochloride.
 

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