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Chemical Structure| 56247-28-0 Chemical Structure| 56247-28-0

Structure of 56247-28-0

Chemical Structure| 56247-28-0

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Product Details of [ 56247-28-0 ]

CAS No. :56247-28-0
Formula : C8H5BrN2O
M.W : 225.04
SMILES Code : O=C1NC2=C(C=CC=N2)C=C1Br
MDL No. :MFCD27925540

Safety of [ 56247-28-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 56247-28-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56247-28-0 ]

[ 56247-28-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5175-14-4 ]
  • [ 56247-28-0 ]
YieldReaction ConditionsOperation in experiment
With pyridine; bromine; In N,N-dimethyl-formamide; at 105.0℃; for 1.0h; Step 3: 3-Bromo-l,8-naphthyridin-2-olA solution of bromine (3.78 g, 23.7 mmol) in pyridine (4 mL) and DMF (8 mL) was added to the product of Step 2 (450 mg, 2.37 mmol) and heated at 1050C for 1 hour. The reaction was cooled; H2O was added, and the mixture filtered. The filtrate was extracted with EtOAc (2x). The organic layers washed with brine and saturated NH4Cl(aq.) and dried over Na2SO4. The solvent was concentrated in vacuo, and the resulting gum was triturated with DCM, and filtered to give a brown solid (156 mg) as desired product. M+H = 224.9.
 

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