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Chemical Structure| 562826-61-3 Chemical Structure| 562826-61-3

Structure of 562826-61-3

Chemical Structure| 562826-61-3

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Product Details of [ 562826-61-3 ]

CAS No. :562826-61-3
Formula : C8H7NOS2
M.W : 197.28
SMILES Code : OC1=CC=C(SC(SC)=N2)C2=C1

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Application In Synthesis of [ 562826-61-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 562826-61-3 ]

[ 562826-61-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 80-48-8 ]
  • [ 55690-60-3 ]
  • [ 562826-61-3 ]
YieldReaction ConditionsOperation in experiment
76% With triethanolamine; boron tribromide; In methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; acetonitrile; A. Preparation of 5-(2-chloroethoxy)-2-methylthio-benzothiazole To a 250 mL flask was added 2-mercapto-5-methoxybenzothiazole (5.1 g, 26 mmol), MeCN (63 mL), methyl p-toluenesulfonate (4.8 g, 26 mmol) and TEA (4.4 mL, 31 mmol). After stirring 16 h at ambient temperature, the solution was concentrated under reduced pressure. The crude material was diluted with EtOAc (200 mL), washed with water (2*75 mL), dried over Na2SO4, filtered, and concentrated. The resulting viscous oil was dissolved in DCM (40 mL), and transferred to an argon-purged 250 mL flask. The solution was cooled to -78 C. prior to the addition of a 1.0 M BBr3 solution in DCM (64 mL). The reaction suspension was allowed to warm to room temperature. After 16 h the reaction solution was cooled to -78 C. and quenched by addition of MeOH (100 mL). The resulting precipitates were isolated by vacuum filtration to yield 5-hydroxy-2-methylthio-benzothiazole (3.9 g, 76%) as a white solid.
 

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