* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With 2-chloro-1,3-dimethylimidazolinium chloride In ethanol at 40℃; for 3 h;
In a 500 mL reaction flask,Add anhydrous ethanol 300mL,80 g of N-acetyl-β-alanine (0.611 mol)86.1 g L-histidine (0.555 mol),98 g of DMC (0.582 mol),Heating up to 40 ,Reaction for 3 hours,Cooling to 5 ,Filter,The filter cake was rinsed with 150 mL of anhydrous ethanol,Solid-dried product (IV) 145g,The yield was 97.9percentHPLC purity> 98.8percent.
Reference:
[1] Patent: CN105461632, 2016, A, . Location in patent: Paragraph 0046
With 2-chloro-1,3-dimethylimidazolinium chloride; In ethanol; at 40℃; for 3h;
In a 500 mL reaction flask,Add anhydrous ethanol 300mL,80 g of N-acetyl-beta-alanine (0.611 mol)86.1 g L-histidine (0.555 mol),98 g of DMC (0.582 mol),Heating up to 40 ,Reaction for 3 hours,Cooling to 5 ,Filter,The filter cake was rinsed with 150 mL of anhydrous ethanol,Solid-dried product (IV) 145g,The yield was 97.9%HPLC purity> 98.8%.