Alternatived Products of [ 564467-91-0 ]
Product Details of [ 564467-91-0 ]
| CAS No. : | 564467-91-0 |
MDL No. : | MFCD20226157 |
| Formula : |
C9H8N2O3
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
192.17
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 564467-91-0 ]
Application In Synthesis of [ 564467-91-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 564467-91-0 ]
- 1
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[ 564467-91-0 ]
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[ 69189-26-0 ]
| Yield | Reaction Conditions | Operation in experiment |
| 100% |
With palladium 10% on activated carbon; hydrogen; In methanol; ethanol; at 20℃; under 760.051 Torr; for 18.0h;Inert atmosphere; |
Pd/C (10%, 96.911 mg, 0.0911 mmol) was added to a stirred solution of 1-34 (700 mg, 3.64 mmol) in MeOH (8 mL) and EtOH (8 mL) under nitrogen atmosphere. The mixture was hydrogenated H2 (atmospheric pressure) at rt for 18h. The mixture was filtered through a pad of diatomaceous earth and the residue was washed with MeOH. The filtrate was evaporated in vacuo to yield 1-35 (590.78 mg, quantitative) as a yellow solid. |
| 86% |
With palladium on activated charcoal; hydrogen; In methanol; at 20℃; for 3.0h; |
To a solution of 2-methyl-6-nitroisoindolin-1-one (62.4) (146 mg, 0.76 mmol) in methanol (14 mL) was added 15mg Pd/C. The reaction mixture was stirred at ambient temperature for 3 h under H2. TLC showed the reaction was complete. The reaction mixture was filtered, and the filtrate was concentrated to afford 6-amino-2-methylisoindolin-1-one (62.5) as a yellow solid (106 mg, 86%). [00893] 1HNMR (400 MHz, CDCl3): δ 3.16 (s, 3H), 3.82 (br, 2H), 4.25 (s, 2H), 6.83 (dd, 1H), 7.11 (d, 1H), 7.18 (d, 1H) |
- 2
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[ 90725-68-1 ]
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[ 74-89-5 ]
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[ 564467-91-0 ]
| Yield | Reaction Conditions | Operation in experiment |
| 100% |
In methanol; water; at 20℃; for 16.0h; |
A solution of methyl 2-(bromomethyl)-5-nitro-benzoate [90725-68-1] (1 g, 3.65 mmol) and methylamine (40 % in water, 0.346 mL, 4.014 mmol) in MeOH (8 mL) was stirred rt for 16 h. Water was added and the mixture was extracted with EtOAc. The combined organic layers were dried over MgS04, filtered and evaporated in vacuo to yield 1-34 (700 mg, quantitative) as yellow solid. |
| 42% |
In methanol; chloroform; at 70℃; for 6.0h;Inert atmosphere; |
To a solution of <strong>[90725-68-1]methyl 2-(bromomethyl)-5-nitrobenzoate</strong> (62.3) (500 mg, 1.82 mmol) in chloroform (15 mL) was added methylamine in methanol solution (2M; 2 mL). The reaction mixture was stirred at 70 C for 6 h under N2. TLC showed the reaction was complete. The reaction mixture was quenched with the addition of water and extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over sodium sulfate, and concentrated to afford the crude product. The crude product was purified by column chromatography (hexane/ethyl acetate: 2/1) to afford 2-methyl-6-nitroisoindolin-1-one (62.4) as a red solid (146 mg, 42%). [00890] 1HNMR (400 MHz, CDCl3): delta 3.24 (s, 3H), 4.50 (s, 2H), 7.62 (d, 1H), 8.41 (dd, 1H), 8.67 (d, 1H). |
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