Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 56824-91-0 | MDL No. : | MFCD00173351 |
Formula : | C12H9Cl2NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | HINLPSGAVZPTIW-UHFFFAOYSA-N |
M.W : | 270.11 | Pubchem ID : | 728974 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
tetrakis(triphenylphosphine) palladium(0); In toluene; | Preparation Example 11 Ethyl 8-Chloro-4-vinylquinoline-3-carboxylate To a solution of 2.0 g (7.4 mmol) of ethyl 4,8-dichloroquinoline-3-carboxylate obtained in the same manner as in Preparation Example 4 in toluene (20 ml) were added tributylvinyltin (2.8 ml) and tetrakis(triphenylphosphine)palladium (171 mg), followed by stirring for 2 hours while heating under reflux. The reaction mixture was filtrated through Celite and concentrated. Then, the residue was purified by silica gel chromatography, to give 1.92 g of the title compound. 1H-NMR (DMSO-d6) delta (ppm): 1.36 (3H, t, J=7.6 Hz), 4.37 (2H, d, J=:7.6 Hz), 5.52 (1H, d, J=18.0 Hz), 5.58 (1H, d, J=16.4 Hz), 7.40 (1H, dd, J=-16.4, 18.0 Hz), 7.70 (1H, t, J=8.0 Hz), 8.11 (1H, d, J=8.0 Hz), 8.25 (1H, d, J=8.0 Hz), 9.24 (1H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | With trichlorophosphate at 100℃; for 0.5h; | A mixture of 8-chloro-4-hydroxyquinoline-3-carboxylic acid ethyl ester (7.94 g, 31.5 mmol; see step (b) above) and POCl3 (6 mL) was stirred at 100 °C for 30 min, cooled and concentrated. The crude material was recrystallised from EtOAc. Yield 5.46 g (68 %) as white flakes. 1H-NMR (CDCl35 400 MHz) δ 9.23 (IH, s), 8.34 (IH, dd), 8.16 (IH5 dd), 7.81 (IH5 dd), 4.44 (2H5 q), 1.39 (3H51). |
With trichlorophosphate |