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Chemical Structure| 56844-18-9 Chemical Structure| 56844-18-9

Structure of 56844-18-9

Chemical Structure| 56844-18-9

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Product Details of [ 56844-18-9 ]

CAS No. :56844-18-9
Formula : C12H7ClN2S
M.W : 246.72
SMILES Code : ClC1=NC(C2=CC=CC=C2)=C(C=CS3)C3=N1
MDL No. :MFCD19689505

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Application In Synthesis of [ 56844-18-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56844-18-9 ]

[ 56844-18-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18740-39-1 ]
  • [ 98-80-6 ]
  • [ 56844-18-9 ]
YieldReaction ConditionsOperation in experiment
60% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 110℃; for 4h;Inert atmosphere; Under a nitrogen stream 2,4-dichlorothieno [2,3-d] pyrimidine (4.2 g, 20.5 mmol), phenylboronic acid (2.5 g,Pd (PPh3) 4 (1.2 g, 5 molpercent) and potassium carbonate (8.5 g, 61.5 mmol)Toluene / H 2 O / Ethanol (80 ml / 40 ml / 40 ml) was added thereto, and the mixture was stirred at 110 ° C for 4 hours.After completion of the reaction, the organic layer was separated using methylene chloride, and water was removed using MgSO4. Solvent in organic layerThe residue was purified by column chromatography to obtain the target compound TP-1 (3.0 g, 12.3 mmol, yield 60percent).
 

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