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Structure of 56951-58-7

Chemical Structure| 56951-58-7

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Product Details of [ 56951-58-7 ]

CAS No. :56951-58-7
Formula : C3H5N3OS
M.W : 131.16
SMILES Code : OCC1=NN=C(N)S1
MDL No. :MFCD12766834
InChI Key :URCCVQJLYSKFBQ-UHFFFAOYSA-N
Pubchem ID :11062424

Safety of [ 56951-58-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 56951-58-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56951-58-7 ]

[ 56951-58-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 64837-53-2 ]
  • [ 56951-58-7 ]
YieldReaction ConditionsOperation in experiment
75 mg With lithium aluminium tetrahydride; In tetrahydrofuran; at 20℃; for 1h;Cooling with ice; 0239-1 A solution of <strong>[64837-53-2]ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate</strong> (340 mg) in tetrahydrofuran (10 mL) was cooled by ice, and lithium aluminum hydride (a 10percent tetrahydrofuran solution, about 2.5 mol/L, 1 mL) was added dropwise thereto, followed by stirring at room temperature for 1 hour. After the reaction mixture was cooled by ice, ethyl acetate (2 mL) was added thereto, followed by stirring for 15 minutes under ice-cooling, and methanol (1 mL) was added thereto, followed by stirring for 5 minutes under ice-cooling. Anhydrous sodium sulfate aqueous solution (anhydrous sodium sulfate: 100 mg, water: 2 mL) was added to the reaction mixture, followed by neutralizing with 2 mol/L hydrochloric acid. The solid matter was separated by filtration, ethyl acetate was added thereto, and liquid-liquid separation was performed. The organic layer was collected by separation, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform-methanol), thereby obtaining (5-amino-1,3,4-thiadiazol-2-yl)methanol (75 mg). 1H-NMR (DMSO-d6) delta: 7.07 (2H, s), 5.74 (1H, t, J=6.1 Hz), 4.55 (2H, d, J=5.9 Hz).
 

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