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Chemical Structure| 57018-52-7 Chemical Structure| 57018-52-7

Structure of 57018-52-7

Chemical Structure| 57018-52-7

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Product Details of [ 57018-52-7 ]

CAS No. :57018-52-7
Formula : C7H16O2
M.W : 132.20
SMILES Code : CC(O)COC(C)(C)C
MDL No. :MFCD00077674

Safety of [ 57018-52-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H372-H336-H226
Precautionary Statements:P501-P260-P270-P240-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P314-P303+P361+P353-P304+P340+P312-P403+P233-P403+P235-P405
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 57018-52-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57018-52-7 ]

[ 57018-52-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 68500-37-8 ]
  • [ 57018-52-7 ]
  • [ 1051315-81-1 ]
YieldReaction ConditionsOperation in experiment
Example 46; l-(2-(7-Methoxyquinolin-4-yloxy)propyl)-5-(thiophen-2-yl)pyridin-2(lH)-one4-(l-teri'-Butoxypropan-2-yloxy)-7-methoxyquinoline. To a stirring solution of l-tert-butoxypropan-2-ol (293 mul, 1937 mumol) in DMF (2.5 mL) under nitrogen was added NaH (93 mg, 3873 mumol) at 23°C. After lOmin, 4-chloro-7- methoxyquinoline (250 mg, 1291 mumol) was added. The mixture was heated to 37°C for 18 h. The reaction was partioned between 5percent NaHCO3 (10 mL) and CH2Cl2 (15percent). The aqueous was extracted with CH2Cl2 (1O mL). The combined <n="82"/>organics were dried with brine and MgSO4, concentrated under reduced pressure from toluene, and purified on silica (12 g)eluting with 0-30percent of 5percent (MeOH/ CH2Cl2). MS (ESI pos. ion) m/z (MH+): 290. Calc'd exact mass for C17H23NO3: 291. 1H NMR (400 MHz, Chloroform-d) delta ppm 1.19 (s, 9 H) 1.44 (d, J=6.26 Hz, 3 H) 3.46 - 3.54 (m, 2 H) 3.69 (dd, J=9.49, 5.77 Hz, 1 H) 3.93 (s, 3 H) 4.69 - 4.77 (m, 1 H) 6.70 (d, J=5.28 Hz, 1 H) 7.12 (dd, J=9.19, 2.54 Hz, 1 H) 7.34 (d, J=2.54 Hz, 1 H) 8.10 (d, J=9.19 Hz, 1 H) 8.63 (d, J=5.48 Hz, 1 H). 13C NMR (101 MHz, Chloroform-d) delta ppm 17.15, 27.45, 50.29, 55.40, 65.09, 73.31, 74.06, 100.45, 106.89, 116.62, 118.04, 123.38, 151.26, 151.58, 160.89, 161.07
 

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