Alternatived Products of [ 571150-08-8 ]
Product Details of [ 571150-08-8 ]
CAS No. : | 571150-08-8 |
MDL No. : | MFCD03982049 |
Formula : |
C10H15ClN2O2S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
262.76
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 571150-08-8 ]
Application In Synthesis of [ 571150-08-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 571150-08-8 ]
- 1
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[ 1344046-13-4 ]
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[ 571150-08-8 ]
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[ 2550442-79-8 ]
Yield | Reaction Conditions | Operation in experiment |
43% |
Stage #1: 3-bromoquinoline-7-carboxylic acid With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 0℃; for 0.25h;
Stage #2: N,N-diethyl 3-amino-6-chlorobenzenesulfonamide In ethyl acetate at 0 - 20℃; for 16h; Inert atmosphere; |
1; II General Experimental Procedure II
General procedure: T3P (35.0 equiv., 50% solution in EtOAc) was added to a stirred solution of the corresponding acid (1.0 equiv.) in pyridine (0.8 M) at 0 °C, and the reaction mixture was stirred for 15 minutes. Then, the corresponding aniline (1.0 equiv.) was added at 0 °C, and the reaction mixture was left to stir at rt for additional 16 hours under Nitrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography and LC/MS. Upon completion of the reaction, the reaction mixture was filtered through a neutral alumina pad twice to remove the excess of T3P. The filtrate was concentrated in vacuo and the crude product was purified by prep- HPLC. After purification, the fractions containing the desired product were concentrated to a minimal volume, filtered through 0.4 ^m syringe filter and lyophilized to afford the product in > 95% purity. |