[ CAS No. 57356-64-6 ]

Name: 57356-64-6|5-Bromo-2-(piperidin-1-yl)pyrimidine|98%
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Product Details of [ 57356-64-6 ]

CAS No. :	57356-64-6	MDL No. :	MFCD00483257
Formula :	C₉H₁₂BrN₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OSEFZQJCFCWHKB-UHFFFAOYSA-N
M.W :	242.12 g/mol	Pubchem ID :	3614682
Synonyms :

Safety of [ 57356-64-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 57356-64-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 57356-64-6 ]

[ 57356-64-6 ] Synthesis Path-Downstream 1~37

Yield	Reaction Conditions	Operation in experiment
	2-Piperidinopyrimidin, Br2;

2
[ 110-89-4 ]
[ 32779-36-5 ]
[ 57356-64-6 ]

Yield	Reaction Conditions	Operation in experiment
	In 1,2-dimethoxyethane at 20℃; for 1h;	5 INTERMEDIATE 5; 5-bromo-2-piperidin-l-ylpyrimidine; 2-chloro-5-bromopyrimidine (3g, 15.5 mmol), piperidine (5.3 g, 62 mmol), and DME (30 mL) were stirred at room temperature for 1 hour. The reaction was extracted with methylenechloride and washed with water three times and the solvent evaporated to yield and off white solid.
	With triethylamine In tetrahydrofuran at 20℃;	8.I To solution of 5-bromo-2-chloro-pyrimidine (3.0 g, 15.5 mmol) in dichloromethane (30 imL) at room temperature was added piperidine (1.53 mL, 15.5 mmol) followed by the dropwise addition of triethylamine (3.23 mL, 23.3 mmol). The reaction was stirred at room temperature overnight. The reaction was diluted with dichloromethane (20 mL), washed with a saturated aqueous sodium bicarbonate solution (50 mL), followed by brine (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Flash chromatography (silica gel; 5% ethyl acetate in hexanes) provided 5-bromo-2-piperidin-1-yl-pyrimidine as a white solid (3.74g, 15.5 mmol).
	With triethylamine In dichloromethane at 20℃;	17; 8.I To solution of 5-bromo-2-chloro-pyrimidine (3.0 g, 15.5 mmol) in dichloromethane (30 mL) at room temperature was added piperidine (1.53 mL, 15.5 mmol) followed by the dropwise addition of triethylamine (3.23 mL, 23.3 mmol). The reaction was stirred at room temperature overnight. The reaction was diluted with dichloromethane (20 mL), washed with a saturated aqueous sodium bicarbonate solution (50 mL), followed by brine (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Flash chromatography (silica gel; 5% ethyl acetate in hexanes) provided 5-bromo-2-piperidin-1-yl-pyrimidine as a white solid (3.74g, 15.5 mmol).

	With triethylamine In dichloromethane at 20℃;	8.I To solution of 5-bromo-2-chloro-pyrimidine (3.0 g, 15.5 mmol) in dichloromethane (30 mL) at room temperature was added piperidine (1.53 mL, 15.5 mmol) followed by the dropwise addition of triethylamine (3.23 mL, 23.3 mmol). The reaction was stirred at room temperature overnight. The reaction was diluted with dichloromethane (20 mL), washed with a saturated aqueous sodium bicarbonate solution (50 mL), followed by brine (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Flash chromatography (silica gel; 5% ethyl acetate in hexanes) provided 5-bromo-2-piperidin-1-yl-pyrimidine as a white solid (3.74g, 15.5 mmol).
	With triethylamine In dichloromethane at 20℃;	8.I Part I: Preparation of 5-bromo-2-piperidin-1-yl-pyrimidineTo solution of 5-bromo-2-chloro-pyrimidine (3.0 g, 15.5 mmol) in dichloromethane (30 mL) at room temperature was added piperidine (1.53 mL, 15.5 mmol) followed by the dropwise addition of triethylamine (3.23 mL, 23.3 mmol). The reaction was stirred at room temperature overnight. The reaction was diluted with dichloromethane (20 mL), washed with a saturated aqueous sodium bicarbonate solution (50 mL), followed by brine (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Flash chromatography (silica gel; 5% ethyl acetate in hexanes) provided 5-bromo-2-piperidin-1-yl-pyrimidine as a white solid (3.74g, 15.5 mmol).
	In ethanol at 80℃; Sealed tube;
	With triethylamine In toluene at 20℃; for 24h;	32 Piperidine (5.1 MI, 51.6 MMOL) was added to a stirred solution of 5-bromo-2-chloropyrimidine (5 g, 25.8 MMOL) and triethylamine (9.0 MI, 64.5 MMOL) in toluene (30 ML). After stirring at room temperature for 24 hours the reaction mixture was diluted with ethyl acetate and washed with 2N hydrochloric acid, brine and dried (magnesium sulfate). The organic layer was filtered, concentrated in vacuo and the resulting residue was purified by column chromatography eluting with ethyl acetate to afford the title compound (D32).

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2006/115895, 2006, A2 Location in patent: Page/Page column 23
[2]Current Patent Assignee: PFIZER INC - WO2008/73461, 2008, A2 Location in patent: Page/Page column 143
[3]Current Patent Assignee: PFIZER INC - WO2008/73929, 2008, A1 Location in patent: Page/Page column 84; 104
[4]Current Patent Assignee: PFIZER INC - WO2008/73934, 2008, A1 Location in patent: Page/Page column 74
[5]Current Patent Assignee: PFIZER INC - WO2008/73936, 2008, A1 Location in patent: Page/Page column 82; 106
[6]Li, Yupeng; Shen, Mengjie; Zhang, Zhang; Luo, Jinfeng; Pan, Xiaofen; Lu, Xiaoyun; Long, Huoyou; Wen, Donghai; Zhang, Fengxiang; Leng, Fang; Li, Yingjun; Tu, Zhengchao; Ren, Xiaomei; Ding, Ke [Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10033 - 10046]
[7]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2004/56369, 2004, A1 Location in patent: Page/Page column 19-20

3
[ 1066-54-2 ]
[ 57356-64-6 ]
C₁₄H₂₁N₃Si [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; triethylamine In toluene at 100℃; for 12h;	6 INTERMEDIATE 6; 5-ethynyl-2-piperidin-l-ylpyrimidine; 2-piperidyl-5-bromopyrimidine (3.5 g, 15 mmol), TMS acetylene (2.1 g, 29 mmol), Palladium tetrakis(triphenylphosphine) (0.3 g, 0.3 mmol), copper (I) iodide (0.05 g, 0.3 mmol), triethylamine (10 mL), and toluene (50 mL) were combined and heated to 100 0C for 12 hours. The solution was filtered, solvent evaporated and the crude material purified on silica (25% EtOAc/hexanes) to yield a white solid. The solid material was dissolved in THF (50 mL) and 1 equivalent of TBAF was added and the solution was stirred for 1 hour at room temperature. Methylene chloride was added and the organic layer was washed 3 times with water and evaporated to yield a white solid.
	With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 20 - 100℃; for 24h; Inert atmosphere; Sealed tube;

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2006/115895, 2006, A2 Location in patent: Page/Page column 23
[2]Li, Yupeng; Shen, Mengjie; Zhang, Zhang; Luo, Jinfeng; Pan, Xiaofen; Lu, Xiaoyun; Long, Huoyou; Wen, Donghai; Zhang, Fengxiang; Leng, Fang; Li, Yingjun; Tu, Zhengchao; Ren, Xiaomei; Ding, Ke [Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10033 - 10046]

4
[ 33513-42-7 ]
[ 57356-64-6 ]
[ 149806-11-1 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 5-bromo-2-(piperidin-1-yl)pyrimidine With n-butyllithium In tetrahydrofuran; hexanes at -78 - -70℃; for 1h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexanes at -70℃; for 1h;	8.II To a solution of 5-bromo-2-piperidin-1-yl-pyrimidine (1.3 g, 5.4 mmol) in anhydrous tetrahydrofuran (30 mL) at -78°C was added 1.6 M n-butyl lithium in hexanes (3.7 mL, 5.93 mmol). The mixture was stirred at a temperature below -70°C for 1 hour. Dimethylformamide (4.2 mL, 53.9 mmol) was added dropwise and the reaction was stirred at a temperature below -70°C for 1 hour. The reaction was quenched with saturated ammonium chloride (10 mL), diluted with water (20 mL) and extracted with ethyl acetate (2 x 20 ml_). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and the solvent removed under reduced pressure to provide a viscous brown oil. Flash chromatography (silica gel; 5-30% ethyl acetate in hexanes) provided 2-piperidin-1-yl-pyrimidine-5-carbaldehyde (0.76 g, 4.0 mmol) as a white solid.
	Stage #1: 5-bromo-2-(piperidin-1-yl)pyrimidine With n-butyllithium In tetrahydrofuran; hexanes at -78 - 70℃; for 1h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexanes at -70℃; for 1h; Stage #3: With ammonium chloride In tetrahydrofuran; hexanes; water	17; 8.II To a solution of 5-bromo-2-piperidin-1-yl-pyrimidine (1.3 g, 5.4 mmol) in anhydrous tetrahydrofuran (30 mL) at -78°C was added 1.6 M n-butyl lithium in hexanes (3.7 mL, 5.93 mmol). The mixture was stirred at a temperature below -70°C for 1 hour. Dimethylformamide (4.2 mL, 53.9 mmol) was added dropwise and the reaction was stirred at a temperature below -70°C for 1 hour. The reaction was quenched with saturated ammonium chloride (10 mL), diluted with water (20 mL) and extracted with ethyl acetate (2 x 20 ml_). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and the solvent removed under reduced pressure to provide a viscous brown oil. Flash chromatography (silica gel; 5-30% ethyl acetate in hexanes) provided 2-piperidin-1-yl-pyrimidine-5-carbaldehyde (0.76 g, 4.0 mmol) as a white solid.
	Stage #1: 5-bromo-2-(piperidin-1-yl)pyrimidine With n-butyllithium In tetrahydrofuran; hexanes at -78 - -70℃; for 1h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexanes at -70℃; for 1h;	8.II; 4 To a solution of 5-bromo-2-piperidin-1-yl-pyrimidine (1.3 g, 5.4 mmol) in anhydrous tetrahydrofuran (30 mL) at -78°C was added 1.6 M n-butyl lithium in hexanes (3.7 mL, 5.93 mmol). The mixture was stirred at a temperature below -70°C for 1 hour. Dimethylformamide (4.2 mL, 53.9 mmol) was added dropwise and the reaction was stirred at a temperature below -70°C for 1 hour. The reaction was quenched with saturated ammonium chloride (10 mL), diluted with water (20 mL) and extracted with ethyl acetate (2 x 20 ml_). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and the solvent removed under reduced pressure to provide a viscous brown oil. Flash chromatography (silica gel; 5-30% ethyl acetate in hexanes) provided 2-piperidin-1-yl-pyrimidine-5-carbaldehyde (0.76 g, 4.0 mmol) as a white solid.

Stage #1: 5-bromo-2-(piperidin-1-yl)pyrimidine With n-butyllithium In tetrahydrofuran; hexanes at -78 - -70℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexanes at -70℃; for 1h; Stage #3: With water; ammonium chloride In tetrahydrofuran; hexanes

8.II Part II: Preparation of 2-piperidin-1-yl-pyrimidine-5-carbaldehydeTo a solution of 5-bromo-2-piperidin-1-yl-pyrimidine (1.3 g, 5.4 mmol) in anhydrous tetrahydrofuran (30 mL) at -78°C was added 1.6 M n-butyl lithium in hexanes (3.7 mL, 5.93 mmol). The mixture was stirred at a temperature below -70°C for 1 hour. Dimethylformamide (4.2 mL, 53.9 mmol) was added dropwise and the reaction was stirred at a temperature below -70°C for 1 hour. The reaction was quenched with saturated ammonium chloride (10 mL), diluted with water (20 mL) and extracted with ethyl acetate (2 x 20 ml_). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and the solvent removed under reduced pressure to provide a viscous brown oil. Flash chromatography (silica gel; 5-30% ethyl acetate in hexanes) provided 2-piperidin-1-yl-pyrimidine-5-carbaldehyde (0.76 g, 4.0 mmol) as a white solid.

Reference： [1]Current Patent Assignee: PFIZER INC - WO2008/73461, 2008, A2 Location in patent: Page/Page column 143; 144
[2]Current Patent Assignee: PFIZER INC - WO2008/73929, 2008, A1 Location in patent: Page/Page column 84; 104-105
[3]Current Patent Assignee: PFIZER INC - WO2008/73934, 2008, A1 Location in patent: Page/Page column 53; 74-75
[4]Current Patent Assignee: PFIZER INC - WO2008/73936, 2008, A1 Location in patent: Page/Page column 82; 106-107

5
[ 720689-55-4 ]
[ 57356-64-6 ]
3-cyclobutyl-7-[2-(1-piperidinyl)-5-pyrimidinyl]oxy}-2,3,4,5-tetrahydro-1H-3-benzazepine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol With pyridine; sodium hydride; copper(I) bromide at 0 - 20℃; for 0.5h; Stage #2: 5-bromo-2-(piperidin-1-yl)pyrimidine for 2h; Heating / reflux;	140 Sodium hydride (60% disp. in mineral oil, 44 mg, 1.1 MMOL) was added to a stirred solution of 3-cyclobutyl-2, 3,4, 5-tetrahydro-1H-benzo [d] azepin-7-ol (E3) (200 mg, 0.92 MMOL) and copper (I) bromide (184 mg, 1.3 MMOL) in pyridine (10 ml) at 0 °C. After stirring for 0.5 hour at room temperature, 5-BROMO-2-(1-PIPERIDINYL) pyrimidine (D32) (0. 669 G, 2.8 MMOL) was added and the reaction mixture heated at reflux for 2 hours. The reaction was allowed to cool, filtered and the filtrate was concentrated in vacuo. The crude residue was dissolved with ethyl acetate and washed with water and brine. The organic layer was dried (magnesium sulfate), filtered and concentrated in vacuo. Purification of the resulting residue by column chromatography eluting with a mixture of. 880 ammonia: ethanol : DICHLOROMETHANE (0.25 : 2.25 : 97.5 to 1: 9: 90) afforded the title compound (E140). MS (ES+) m/e 379 [M+H] +.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2004/56369, 2004, A1 Location in patent: Page/Page column 51-52

6
[ 57356-64-6 ]
[ 1355063-50-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 1.2: 0.33 h / 0 °C / Inert atmosphere 1.3: 0.17 h / 0 °C 2.1: caesium carbonate; pyridine; copper / 16 h / 120 °C 2.2: 16 h / 30 °C

Reference： [1]Current Patent Assignee: PFIZER INC - US2012/10183, 2012, A1

7
[ 57356-64-6 ]
[ 809236-47-3 ]

Yield	Reaction Conditions	Operation in experiment
98%	Stage #1: 5-bromo-2-(piperidin-1-yl)pyrimidine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: With Trimethyl borate In tetrahydrofuran; hexane at 0℃; for 0.333333h; Inert atmosphere; Stage #3: With dihydrogen peroxide; acetic acid In tetrahydrofuran; hexane; water at 0℃; for 0.166667h;	10 A solution of 5-bromo-2-piperidin-1-ylpyrimidine (1.00 g, 4.15 mmol) in freshly distilled THF (5.2 mL), was purged with argon and cooled to -78° C. To the cooled reaction mixture was added drop-wise a solution of n-butyllithium in hexane (2.5 M, 1.99 mL, 4.98 mmol). The reaction mixture was stirred at -78° C. for 10 minutes and then added dropwise over 10 minutes to a solution of trimethyl borate (0.559 mL, 4.98 mmol) in THF (5.2 mL), which had been purged with argon and cooled to 0° C. The resulting reaction mixture was stirred at 0° C. for a further 20 minutes, followed by addition of acetic acid (0.356 mL, 6.22 mmol). After a further 5 minutes of stirring, a 30% aqueous solution of hydrogen peroxide (0.517 mL, 4.57 mmol) was added dropwise and stirring continued at 0° C. for 5 minutes. A saturated aqueous solution of sodium bisulfite (50 mL) was added and the mixture extracted with EtOAc. The organic extract was washed with a saturated aqueous brine solution, dried over anhydrous sodium sulfate, filtered over Celite and concentrated in vacuo. The crude material was purified using silica gel chromatography eluting with 25% EtOAC in hexane to afford the title compound (728 mg, 98%):1H NMR (400 MHz, CDCl3): δ 1.40-1.70 (br, 6H), 3.55-3.75 (br, 4H), 8.05 (d, 2H). MS m/z 180 [MH]+, 178 [M-H]- CHN Theory-C, 60.32%, H, 7.31%, N, 23.45%CHN Found-C, 60.32%; H, 7.43%; N, 23.10%.

Reference： [1]Current Patent Assignee: PFIZER INC - US2012/10183, 2012, A1 Location in patent: Page/Page column 42

8
[ 57356-64-6 ]
[ 1196156-92-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 24 h / 20 - 100 °C / Inert atmosphere; Sealed tube 2: potassium carbonate / 0.5 h / 20 °C / Inert atmosphere

Reference： [1]Li, Yupeng; Shen, Mengjie; Zhang, Zhang; Luo, Jinfeng; Pan, Xiaofen; Lu, Xiaoyun; Long, Huoyou; Wen, Donghai; Zhang, Fengxiang; Leng, Fang; Li, Yingjun; Tu, Zhengchao; Ren, Xiaomei; Ding, Ke [Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10033 - 10046]

9
[ 57356-64-6 ]
[ 1407999-94-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 24 h / 20 - 100 °C / Inert atmosphere; Sealed tube 2: potassium carbonate / 0.5 h / 20 °C / Inert atmosphere 3: copper(II) sulfate; sodium L-ascorbate / water; <i>tert</i>-butyl alcohol / 90 °C

10
[ 557-21-1 ]
[ 57356-64-6 ]
2-(piperidin-1-yl)pyrimidine-5-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96%	With [(2-di-tert-butylphosphino-2′,4′,6′-triisopropyl-1, 1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)] palladium(II) methanesulfonate In tetrahydrofuran; water at 40℃; for 18h; Inert atmosphere;
96%	With C₁₂H₁₀N^(1-)CH₃O₃S^(1-)Pd⁽²⁺⁾*C₃₉H₃₂OP₂ In tetrahydrofuran; water at 65℃; for 5h; Micellar solution;

Reference： [1]Cohen, Daniel T.; Buchwald, Stephen L. [Organic Letters, 2015, vol. 17, # 2, p. 202 - 205]
[2]Thakore, Ruchita R.; Takale, Balaram S.; Singhania, Vani; Gallou, Fabrice; Lipshutz, Bruce H. [ChemCatChem, 2021, vol. 13, # 1, p. 212 - 216]

11
[ 57356-64-6 ]
[ 22539-51-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: potassium methanolate / 1,2-dimethoxyethane / 0.17 h / 30 °C 1.2: 1 h / 30 °C 2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 100 °C

Reference： [1]Yamamoto, Eiji; Ukigai, Satoshi; Ito, Hajime [Chemical Science, 2015, vol. 6, # 5, p. 2943 - 2951]

12
[ 185990-03-8 ]
[ 57356-64-6 ]
[ 1015242-08-6 ]

Yield	Reaction Conditions	Operation in experiment
71%	Stage #1: dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane With potassium methanolate In 1,2-dimethoxyethane at 30℃; for 0.166667h; Stage #2: 5-bromo-2-(piperidin-1-yl)pyrimidine In 1,2-dimethoxyethane at 30℃; for 1h;

Reference： [1]Yamamoto, Eiji; Ukigai, Satoshi; Ito, Hajime [Chemical Science, 2015, vol. 6, # 5, p. 2943 - 2951]

13
[ 1257628-83-3 ]
[ 57356-64-6 ]
[ 1257628-60-6 ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; palladium diacetate; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine In N,N-dimethyl-formamide at 60℃; Sealed tube; Inert atmosphere;	3-((2-(cyclopropylamino)pyrimidin-5-yl)ethynyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide General procedure: A mixture of 3-ethynyl-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide 8 (192 mg, 0.5 mmol), N-cyclopropyl-5-bromopyrimidin-2-amine9 (107 mg,0.5 mmol), Cu(I)iodide (19mg, 0.1mmol), Pd(OAc)2 (2.2 mg, 0.01 mmol), PCy3 (2.8 mg,0.01 mmol), DIPEA (193 mg, 1.5 mmol), and DMF (3 mL) were added to a sealed tube. The tube was evacuated and backfilled with argon (3 cycles). After stirring at 60°C for 12 h, the reaction mixture was filtered and washed three times with EtOAc. The solvent was removed under vacuum and the resultant crude material was purified by column chromatography to give the title compound 4e (193 mg, yield 75%).

Reference： [1]Lu, Xiaoyun; Zhang, Zhang; Ren, Xiaomei; Pan, Xiaofeng; Wang, Deping; Zhuang, Xiaoxi; Luo, Jingfeng; Yu, Rongmin; Ding, Ke [Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3458 - 3463]

14
[ 5459-93-8 ]
[ 57356-64-6 ]
N-cyclohexyl-N-ethyl-2-(piperidin-1-yl)pyrimidin-5-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
61%	With cyclopentyl methyl ether; methanesulfonato(2-bis(3,5-di(trifluoromethyl)phenylphosphino)-3,6-dimethoxy-2',6'-bis(dimethylamino)-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II); 2'-(bis(3,5-bis(trifluoromethyl)phenyl)phosphanyl)-3',6'-dimethoxy-N²,N²,N⁶,N⁶-tetramethyl-[1,1'-biphenyl]-2,6-diamine; sodium t-butanolate at 60℃; for 16h; Inert atmosphere;

Reference： [1]Park, Nathaniel H.; Vinogradova, Ekaterina V.; Surry, David S.; Buchwald, Stephen L. [Angewandte Chemie - International Edition, 2015, vol. 54, # 28, p. 8259 - 8262]

15
[ 57356-64-6 ]
4-phenyl-2-(2-(piperidin-1-yl)pyrimidin-5-yl)butanenitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,3-dioxane / 24 h / 110 °C / Inert atmosphere 2: (S)-4-benzyl-2-(2-(bis(4-methoxy-3,5-dimethylphenyl)phosphanyl)phenyl)-4,5-dihydrooxazole; manganese; chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Sealed tube

Reference： [1]Kadunce, Nathaniel T.; Reisman, Sarah E. [Journal of the American Chemical Society, 2015, vol. 137, # 33, p. 10480 - 10483]

16
[ 57356-64-6 ]
4-phenyl-2-(2-(piperidin-1-yl)pyrimidin-5-yl)butanenitrile [ No CAS ]
C₁₉H₂₂N₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,3-dioxane / 24 h / 110 °C / Inert atmosphere 2: (S)-4-benzyl-2-(2-(bis(4-methoxy-3,5-dimethylphenyl)phosphanyl)phenyl)-4,5-dihydrooxazole; manganese; chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Sealed tube

Reference： [1]Kadunce, Nathaniel T.; Reisman, Sarah E. [Journal of the American Chemical Society, 2015, vol. 137, # 33, p. 10480 - 10483]

17
[ 57356-64-6 ]
5-iodo-2-(piperidin-1-yl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96%	With copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine In 1,3-dioxane at 110℃; for 24h; Inert atmosphere;

Reference： [1]Kadunce, Nathaniel T.; Reisman, Sarah E. [Journal of the American Chemical Society, 2015, vol. 137, # 33, p. 10480 - 10483]

18
[ 57356-64-6 ]
C₂₄H₃₄N₄O₂ [ No CAS ]
C₂₄H₃₄N₄O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,3-dioxane / 24 h / 110 °C / Inert atmosphere 2: (S)-4-benzyl-2-(2-(bis(4-methoxy-3,5-dimethylphenyl)phosphanyl)phenyl)-4,5-dihydrooxazole; manganese; chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Sealed tube 3: nickel; hydrogen / methanol / 3.5 h / Inert atmosphere
	Multi-step reaction with 3 steps 1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,3-dioxane / 24 h / 110 °C / Inert atmosphere 2: (S)-4-benzyl-2-(2-(bis(4-methoxy-3,5-dimethylphenyl)phosphanyl)phenyl)-4,5-dihydrooxazole; manganese; chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Sealed tube 3: nickel; hydrogen / methanol / 3.5 h / Inert atmosphere

Reference： [1]Kadunce, Nathaniel T.; Reisman, Sarah E. [Journal of the American Chemical Society, 2015, vol. 137, # 33, p. 10480 - 10483]
[2]Kadunce, Nathaniel T.; Reisman, Sarah E. [Journal of the American Chemical Society, 2015, vol. 137, # 33, p. 10480 - 10483]

19
[ 57356-64-6 ]
C₁₉H₂₄N₄O [ No CAS ]
C₁₉H₂₄N₄O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,3-dioxane / 24 h / 110 °C / Inert atmosphere 2: (S)-4-benzyl-2-(2-(bis(4-methoxy-3,5-dimethylphenyl)phosphanyl)phenyl)-4,5-dihydrooxazole; manganese; chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Sealed tube 3: bis(dimethylphosphinous acid-<SUB>k</SUB>P)dimethylphosphinyl-<SUB>k</SUB>P-hydridoplatinum(II) / water; ethanol / 36 h / 65 °C / Inert atmosphere; Sealed tube
	Multi-step reaction with 3 steps 1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,3-dioxane / 24 h / 110 °C / Inert atmosphere 2: (S)-4-benzyl-2-(2-(bis(4-methoxy-3,5-dimethylphenyl)phosphanyl)phenyl)-4,5-dihydrooxazole; manganese; chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Sealed tube 3: bis(dimethylphosphinous acid-<SUB>k</SUB>P)dimethylphosphinyl-<SUB>k</SUB>P-hydridoplatinum(II) / water; ethanol / 36 h / 65 °C / Inert atmosphere; Sealed tube

20
potassium vinyltrifluoroborate [ No CAS ]
[ 57356-64-6 ]
2-(piperidin-1-yl)-5-vinylpyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With ((2-dicyclohexylphosphino-2',4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2‘-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate); potassium carbonate In tetrahydrofuran; water at 60℃; for 12h; Inert atmosphere;
65%	With potassium carbonate In tetrahydrofuran; water for 16h; Inert atmosphere; Reflux;

Reference： [1]Wang, Yi-Ming; Buchwald, Stephen L. [Journal of the American Chemical Society, 2016, vol. 138, # 15, p. 5024 - 5027]
[2]Gribble, Michael W.; Pirnot, Michael T.; Bandar, Jeffrey S.; Liu, Richard Y.; Buchwald, Stephen L. [Journal of the American Chemical Society, 2017, vol. 139, # 6, p. 2192 - 2195]

21
[ 57356-64-6 ]
5-(pent-4-en-2-yl)-2-(piperidin-1-yl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: ((2-dicyclohexylphosphino-2',4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2‘-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate); potassium carbonate / tetrahydrofuran; water / 12 h / 60 °C / Inert atmosphere 2: C₃₄H₃₆P₂*CuH; lithium tert-butoxide; (dimethoxy)methylsilane / tetrahydrofuran / 20 °C / Inert atmosphere; Schlenk technique; Sealed tube

Reference： [1]Wang, Yi-Ming; Buchwald, Stephen L. [Journal of the American Chemical Society, 2016, vol. 138, # 15, p. 5024 - 5027]

22
[ 57356-64-6 ]
(R)-5-(pent-4-en-2-yl)-2-(piperidin-1-yl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: ((2-dicyclohexylphosphino-2',4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2‘-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate); potassium carbonate / tetrahydrofuran; water / 12 h / 60 °C / Inert atmosphere 2: C₃₄H₃₆P₂*CuCl; lithium tert-butoxide; (dimethoxy)methylsilane / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Schlenk technique; Sealed tube

Reference： [1]Wang, Yi-Ming; Buchwald, Stephen L. [Journal of the American Chemical Society, 2016, vol. 138, # 15, p. 5024 - 5027]

23
C₂₄H₃₉BO₂ [ No CAS ]
[ 57356-64-6 ]
C₂₇H₃₉N₃ [ No CAS ]
(R,E)-5-(5-methyl-1-phenylundec-3-en-5-yl)-2-(piperidin-1-yl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With palladium diacetate; potassium hydroxide; ruphos In 1,4-dioxane; water at 60℃; for 14h; Inert atmosphere; Sealed tube; enantiospecific reaction;

Reference： [1]Potter, Bowman; Edelstein, Emma K.; Morken, James P. [Organic Letters, 2016, vol. 18, # 13, p. 3286 - 3289]

24
C₁₄H₂₀BO₂^(1-) [ No CAS ]
[ 57356-64-6 ]
(R)-5-(2-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)-2-(piperidin-1-yl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83.8 mg	With (SP, S′P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene; palladium diacetate In tetrahydrofuran; dimethyl sulfoxide at 60℃; for 24h; Inert atmosphere; Sealed tube; enantioselective reaction;

Reference： [1]Lovinger, Gabriel J.; Aparece, Mark D.; Morken, James P. [Journal of the American Chemical Society, 2017, vol. 139, # 8, p. 3153 - 3160]

25
C₁₄H₂₀BO₂^(1-) [ No CAS ]
[ 57356-64-6 ]
5-(2-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)-2-(piperidin-1-yl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With (SP, S′P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene; C₆₄H₇₄FeN₂O₄P₂; palladium diacetate In tetrahydrofuran; dimethyl sulfoxide at 60℃; for 24h; Inert atmosphere; Sealed tube;

Reference： [1]Lovinger, Gabriel J.; Aparece, Mark D.; Morken, James P. [Journal of the American Chemical Society, 2017, vol. 139, # 8, p. 3153 - 3160]

26
[ 57356-64-6 ]
C₁₇H₂₃N₃Si [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium carbonate / tetrahydrofuran; water / 16 h / Inert atmosphere; Reflux 2: copper diacetate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane / 12 h / 20 °C / Inert atmosphere; Glovebox; Sealed tube

Reference： [1]Gribble, Michael W.; Pirnot, Michael T.; Bandar, Jeffrey S.; Liu, Richard Y.; Buchwald, Stephen L. [Journal of the American Chemical Society, 2017, vol. 139, # 6, p. 2192 - 2195]

27
[ 57356-64-6 ]
(S)-1-(2-(piperidin-1-yl)pyrimidin-5-yl)ethan-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: potassium carbonate / tetrahydrofuran; water / 16 h / Inert atmosphere; Reflux 2.1: phenylsilane; copper diacetate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane / 12 h / 20 °C / Inert atmosphere; Glovebox; Sealed tube 2.2: K₂EDTA•(H₂O)₂ / 0.67 h / 20 °C 2.3: 20 h / 20 °C

Reference： [1]Gribble, Michael W.; Pirnot, Michael T.; Bandar, Jeffrey S.; Liu, Richard Y.; Buchwald, Stephen L. [Journal of the American Chemical Society, 2017, vol. 139, # 6, p. 2192 - 2195]

28
(1-methyl-1H-indol-5-yl)boronic acid [ No CAS ]
[ 57356-64-6 ]
1-methyl-5-(2-(piperidin-1-yl)pyrimidin-5-yl)-1H-indole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97%	With potassium phosphate monohydrate; C₅₀H₆₀F₃NO₆PPdS In water at 55℃; for 18h;
92%	With potassium phosphate monohydrate; C₆₆H₈₄O₁₀P₂Pd In water; ethyl acetate; toluene at 45℃; for 3.5h; Inert atmosphere;

Reference： [1]Thakore, Ruchita R.; Takale, Balaram S.; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. [ACS Catalysis, 2019, p. 11647 - 11657]
[2]Landstrom, Evan B.; Handa, Sachin; Aue, Donald H.; Gallou, Fabrice; Lipshutz, Bruce H. [Green Chemistry, 2018, vol. 20, # 15, p. 3436 - 3443]

29
[ 75-05-8 ]
[ 57356-64-6 ]
2-(piperidin-1-yl)pyrimidine-5-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	With 1,10-Phenanthroline; hexakis(acetonitrile)nickel(II) tetrafluoroborate; 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-diaza-2,5-cyclo-hexadiene at 80℃; for 24h;

Reference： [1]Ueda, Yohei; Tsujimoto, Nagataka; Yurino, Taiga; Tsurugi, Hayato; Mashima, Kazushi [Chemical Science, 2019, vol. 10, # 4, p. 994 - 999]

30
[ 768-60-5 ]
[ 57356-64-6 ]
C₁₈H₁₉N₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	With di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; potassium phosphate monohydrate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)] In water at 45℃; for 8h; Inert atmosphere;

Reference： [1]Jin, Bo; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. [Chemical Science, 2019, vol. 10, # 12, p. 3481 - 3485]

31
[ 1679-18-1 ]
[ 57356-64-6 ]
C₁₅H₁₆ClN₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate monohydrate; C₅₀H₆₀F₃NO₆PPdS In water at 55℃; for 16h;

Reference： [1]Thakore, Ruchita R.; Takale, Balaram S.; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. [ACS Catalysis, 2019, p. 11647 - 11657]

32
(1-methyl-1H-indol-5-yl)boronic acid [ No CAS ]
[ 57356-64-6 ]
C₁₈H₂₂N₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate monohydrate; palladium diacetate; N<SUB>2</SUB>Phos In water; toluene at 45℃;

Reference： [1]Akporji, Nnamdi; Andersen, Joel; Aue, Donald H.; Cortes-Clerget, Margery; Gallou, Fabrice; Landstrom, Evan; Lipshutz, Bruce H.; Thakore, Ruchita R. [Chemical Science, 2020, vol. 11, # 20, p. 5205 - 5212]

33
[ 110-89-4 ]
[ 38353-06-9 ]
[ 57356-64-6 ]

Yield	Reaction Conditions	Operation in experiment
70%	With copper acetylacetonate; di-tert-butyl peroxide; N,N-dimethyl-formamide at 100℃; for 10h; Green chemistry;

Reference： [1]Chen, Peng; Luo, Kaixiu; Yu, Xianglin; Yuan, Xu; Liu, Xiaoyu; Lin, Jun; Jin, Yi [Organic Letters, 2020, vol. 22, # 16, p. 6547 - 6551]

34
[ 138572-79-9 ]
[ 57356-64-6 ]
(R)-3-methyl-2-((2-(piperidin-1-yl)pyrimidin-5-yl)methyl)butan-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	Stage #1: tert-butyldimethyl(3-methyl-2-methylenebutoxy)silane; 5-bromo-2-(piperidin-1-yl)pyrimidine With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; (dimethoxy)methylsilane; di(2-(2′-amino-1,1′-biphenyl))palladium(II) methanesulfonate dimer; copper (I) acetate; cesium benzoate In tetrahydrofuran at 45℃; for 16h; Inert atmosphere; Sealed tube; Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 45℃; for 10h; Inert atmosphere; Sealed tube; enantioselective reaction;

Reference： [1]Buchwald, Stephen L.; Lu, Zhaohong [Angewandte Chemie - International Edition, 2020, vol. 59, # 37, p. 16128 - 16132][Angew. Chem., 2020, vol. 132, # 37, p. 16262 - 16266,5]

35
cyanide ion [ No CAS ]
[ 57356-64-6 ]
C₉⁽¹³⁾CH₁₂N₃⁽¹⁵⁾N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	With C₁₂H₁₀N^(1-)CH₃O₃S^(1-)Pd⁽²⁺⁾*C₃₉H₃₂OP₂ In tetrahydrofuran; water at 65℃; for 20h; Micellar solution;

Reference： [1]Thakore, Ruchita R.; Takale, Balaram S.; Singhania, Vani; Gallou, Fabrice; Lipshutz, Bruce H. [ChemCatChem, 2021, vol. 13, # 1, p. 212 - 216]

36
[ 459-03-0 ]
[ 57356-64-6 ]
1-(4-fluorophenyl)-1-(2-(piperidin-1-yl)pyrimidin-5-yl)propan-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	With di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); TPGS-750-M; potassium <i>tert</i>-butylate In water at 45℃; for 16h; Inert atmosphere; Sealed tube; Green chemistry;

Reference： [1]Gallou, Fabrice; Lipshutz, Bruce H.; Roa, Daniel E.; Wood, Alex B. [Green Chemistry, 2021, vol. 23, # 13, p. 4858 - 4865]

37
[ 75-16-1 ]
[ 57356-64-6 ]
5-methyl-2-(piperidin-1-yl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With C₃₈H₅₆Cl₂FeP₂Pd In tetrahydrofuran at 20℃;

Reference： [1]Colacot, Thomas J.; Gao, Peng; Xu, Guolin [ACS Catalysis, 2022, vol. 12, # 9, p. 5123 - 5135]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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Code	Phrase
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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
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P233	Keep container tightly closed.
P234	Keep only in original container.
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P241	Use explosion-proof electrical/ventilating/lighting/equipment.
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P280	Wear protective gloves/protective clothing/eye protection/face protection.
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Response
Code	Phrase
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P321
P322
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P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
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P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
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Storage
Code	Phrase
P401
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Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 57356-64-6 ]

Quality Control of [ 57356-64-6 ]

Related Doc. of [ 57356-64-6 ]

Product Details of [ 57356-64-6 ]

Safety of [ 57356-64-6 ]

Application In Synthesis of [ 57356-64-6 ]

[ 57356-64-6 ] Synthesis Path-Downstream 1~37

Related Functional Groups of [ 57356-64-6 ]

Bromides

Related Parent Nucleus of [ 57356-64-6 ]

Piperidines

Pyrimidines

Precautionary Statements-General

Prevention

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Related Functional Groups of
[ 57356-64-6 ]

Related Parent Nucleus of
[ 57356-64-6 ]