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[ CAS No. 57455-06-8 ]

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2D
Chemical Structure| 57455-06-8
Chemical Structure| 57455-06-8
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Product Details of [ 57455-06-8 ]

CAS No. :57455-06-8MDL No. :MFCD00004635
Formula : C7H7IO Boiling Point : 254.7°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :234.03Pubchem ID :-
Synonyms :

Computed Properties of [ 57455-06-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 57455-06-8 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 57455-06-8 ]

  • Upstream synthesis route of [ 57455-06-8 ]
  • Downstream synthetic route of [ 57455-06-8 ]

[ 57455-06-8 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 57455-06-8 ]
  • [ 60076-09-7 ]
YieldReaction ConditionsOperation in experiment
100% With thionyl chloride In dichloromethane at 20℃; for 30 h; Reflux A solution of 3-iodobenzyi alcohol (600 mg, 2.56 mmol) in DCM (3ml) was treated with thionyl chloride (3 ml, 41.3 mmol) and stirred at ambient temperature for 18h, before addition of further thionyl chloride (1 ml, 13.7 mmol) and heating to reflux for 12h. The cooled solution was basified with 50percent NaOH, diluted with water and extracted with DCM, The combined organics were dried over MgS04, filtered and evaporated to afford a clear syrup which crystallises on standing to give 3-iodobenzyl chloride as a white solid (650mg, quant.).
Reference: [1] Patent: WO2011/86085, 2011, A1, . Location in patent: Page/Page column 39-40
[2] Recueil des Travaux Chimiques des Pays-Bas, 1923, vol. 42, p. 522
[3] Patent: EP1386913, 2004, A1, . Location in patent: Page 94
[4] Patent: WO2017/72021, 2017, A1, . Location in patent: Page/Page column 76
  • 2
  • [ 10026-13-8 ]
  • [ 57455-06-8 ]
  • [ 60076-09-7 ]
Reference: [1] Recueil des Travaux Chimiques des Pays-Bas, 1923, vol. 42, p. 522
  • 3
  • [ 696-41-3 ]
  • [ 57455-06-8 ]
  • [ 618-51-9 ]
Reference: [1] Trans. roy. Soc. Canada, 1934, vol. <3> 28 III, p. 97,98
[2] Trans. roy. Soc. Canada, 1934, vol. <3> 28 III, p. 97,98
  • 4
  • [ 57455-06-8 ]
  • [ 696-41-3 ]
YieldReaction ConditionsOperation in experiment
95% With pyridinium chlorochromate In dichloromethane at 20℃; for 2 h; 3-Iodobenzaldehyde (12) A suspension of pyridinium chlorochromate (2.45 g, 11.4 mmol) and dry celite (-2. 00 g) in dry dichloromethane (20 ml) was stirred at room temperature for 15 min. 3-Iodobenzyl alcohol (11) (1.02 g, 4.35 mmol) in dry dichloromethane (5 ml) was added. The suspension was shielded from light and stirred at room temperature for 2 h after which it was diluted with ether, and filtered through celite. The cloudy brown filtrate was concentrated to a red- brown gummy paste which was re-dissolved in dichloromethane and passed through a short silica column, eluting with dichloromethane. This gave a clear, colourless solution which was concentrated to give 3-iodobenzaldehyde (12) as a white solid (0.953 g, 95percent). 1H nmr (400 Mz, CDC13) : 67. 29 (t, J 7. 8 Hz, 1H) H5; 7.85 (brd, J 7. 8 Hz, 1H) H6; 7.96 (brd, J7. 8 Hz, 1H) H4; 8.21 (brs, 1H) H2; 9.93 (s, 1H) CHO.
80% With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide In dichloromethane; acetonitrile at 20℃; for 3 h; 4 A molecular sieves A solution of 3-iodobenzyl alcohol (Aldrich, 4.72g, 20 mmol) in dichloromethane (50mL) and acetonitrile (5mL) was treated sequentially with 4 A molecular sieves powder (5g), tetra-n-propyl ammoniumperruthenate (0. 1 g) and N-methyl morpholine-N-oxide (2.34g, 40mmol). After stirring at ambient temperature for 3h, the reaction mixture was diluted with hexane and subjected to flash column chromatography over silica gel (230-400mesh) using 6-10percent ethyl acetate in hexane as the eluent to afford the title compound (3.7g, 80percent). It was used as such for the next step.
80% With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide In dichloromethane; acetonitrile at 20℃; for 3 h; Molecular sieve 3-Iodo-benzaldehyde; A solution of 3-iodobenzyl alcohol (Aldrich, 4.72g, 20 mmol) in dichloromethane (50mL) and acetonitrile (5mL) was treated sequentially with 4 A molecular sieves powder (5g), tetra-n-propyl ammoniumperruthenate (0. lg) and N- methyl morpholine-N-oxide (2.34g, 40mmol). After stirring at ambient temperature for 3h, the reaction mixture was diluted with hexane and subjected to flash column chromatography over silica gel (230-400mesh) using 6-10percent ethyl acetate in hexane as the eluent to afford the title compound (3.7g, 80percent). It was used as such for the next step
90 %Chromat. With dihydrogen peroxide In water; acetonitrile for 4 h; Reflux General procedure: In a 25 mL round-bottomed flask equipped with a reflux condenser, a mixture of 1 g PWM/SiO2(M = Cr, Mn, Fe, Co, Ni, and Cu)catalyst containing 0.03 mmol POM, 3 mL acetonitrile and 1 mmol of alcohol was added. Then 1 mL of H2O2 30percent was added and the mixture was refluxed for 2 h with stirring. The progress of the reaction was monitored by GC equipped with a flame ionization detector and a silica pack column. At the end of reaction, the catalyst was filtered out and 10 mL NaHCO3 10percent was added. The organic phase extracted with chloroform and dried. Flash chromatography on a short column of silica gel with ethyl acetate:n-hexane as eluent gave pure products.

Reference: [1] Advanced Synthesis and Catalysis, 2004, vol. 346, # 7, p. 767 - 776
[2] Patent: WO2005/82894, 2005, A1, . Location in patent: Page/Page column 41-42
[3] Bulletin of the Chemical Society of Ethiopia, 2013, vol. 27, # 1, p. 131 - 136
[4] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 20, p. 3047 - 3052
[5] Tetrahedron Asymmetry, 2001, vol. 12, # 4, p. 585 - 596
[6] European Journal of Organic Chemistry, 2008, # 19, p. 3328 - 3334
[7] Synthetic Communications, 1988, vol. 18, # 1, p. 69 - 76
[8] Patent: WO2005/58301, 2005, A1, . Location in patent: Page/Page column 78
[9] Patent: WO2005/58798, 2005, A2, . Location in patent: Page/Page column 49
[10] Journal of the American Chemical Society, 2018, vol. 140, # 28, p. 8652 - 8656
[11] Chemistry - A European Journal, 2002, vol. 8, # 9, p. 2005 - 2010
[12] Advanced Synthesis and Catalysis, 2003, vol. 345, # 12, p. 1341 - 1352
[13] Tetrahedron, 1994, vol. 50, # 28, p. 8301 - 8316
[14] International Journal of Chemical Kinetics, 1997, vol. 29, # 1, p. 9 - 16
[15] Journal of Chemical Research, Miniprint, 1998, # 9, p. 2251 - 2272
[16] Journal of the American Chemical Society, 1999, vol. 121, # 39, p. 9073 - 9087
[17] Journal of Chemical Research, 2004, # 9, p. 581 - 584
[18] Journal of the Chemical Society. Perkin Transactions 2, 2002, # 6, p. 1151 - 1157
[19] Advanced Synthesis and Catalysis, 2003, vol. 345, # 4, p. 497 - 505
[20] Patent: US2006/111394, 2006, A1, . Location in patent: Page/Page column 14-15
[21] Tetrahedron, 2009, vol. 65, # 34, p. 6805 - 6809
[22] E-Journal of Chemistry, 2011, vol. 8, # 1, p. 264 - 268
[23] Journal of Molecular Catalysis A: Chemical, 2014, vol. 392, p. 8 - 15
[24] Journal of the Iranian Chemical Society, 2016, vol. 13, # 8, p. 1463 - 1470
[25] Angewandte Chemie - International Edition, 2018, vol. 57, # 33, p. 10535 - 10539[26] Angew. Chem., 2018, vol. 130, # 33, p. 10695 - 10699,5
  • 5
  • [ 67-56-1 ]
  • [ 57455-06-8 ]
  • [ 618-91-7 ]
Reference: [1] Journal of the American Chemical Society, 2013, vol. 135, # 29, p. 10776 - 10782
  • 6
  • [ 201230-82-2 ]
  • [ 57455-06-8 ]
  • [ 52010-98-7 ]
  • [ 100-51-6 ]
Reference: [1] Journal of the American Chemical Society, 1983, vol. 105, # 24, p. 7175 - 7176
[2] Journal of the American Chemical Society, 1986, vol. 108, p. 452
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