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[ CAS No. 5777-20-8 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 5777-20-8
Chemical Structure| 5777-20-8
Structure of 5777-20-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 5777-20-8 ]

CAS No. :5777-20-8 MDL No. :MFCD16996230
Formula : C3H3NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 85.06 Pubchem ID :-
Synonyms :

Safety of [ 5777-20-8 ]

Signal Word:Warning Class:
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 UN#:
Hazard Statements:H302-H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 5777-20-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5777-20-8 ]

[ 5777-20-8 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 127-07-1 ]
  • [ 623-47-2 ]
  • [ 1001-26-9 ]
  • [ 10601-80-6 ]
  • [ 5777-20-8 ]
  • 2-N-carboxamido-5-ethoxy-3 isoxazolidinone [ No CAS ]
  • 2
  • [ 141-52-6 ]
  • [ 623-47-2 ]
  • [ 1001-26-9 ]
  • [ 10601-80-6 ]
  • [ 5777-20-8 ]
  • 2-N-carboxamido-5-ethoxy-3 isoxazolidinone [ No CAS ]
  • 3
  • [ 623-47-2 ]
  • [ 1001-26-9 ]
  • [ 10601-80-6 ]
  • [ 5777-20-8 ]
  • 2-N-carboxamido-5-ethoxy-3 isoxazolidinone [ No CAS ]
  • 4
  • [ 16156-58-4 ]
  • [ 5777-20-8 ]
  • [ 873445-45-5 ]
YieldReaction ConditionsOperation in experiment
75% With potassium hydroxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 20℃; for 4h;
  • 5
  • [ 5777-20-8 ]
  • [ 2446-83-5 ]
  • [ 168828-82-8 ]
  • [ 252260-22-3 ]
YieldReaction ConditionsOperation in experiment
69% With triphenylphosphine; In tetrahydrofuran; EXAMPLE 39 5(R)-Isoxazol-3-yloxymethyl-3-(4-morpholino-3-fluoro-phenyl)oxazolidin-2-one Prepared by the general method of Example 1 using as starting material 5(R)-hydroxymethyl-3-(4-morpholino-3-fluoro-phenyl)oxazolidin-2-one (WO95/07271; 300 mg, 1.01 mmol), 3-hydroxyisoxazole (95 mg, 1.12 mmol), diisopropylazodicarboxylate (225 mg, 1.11 mmol) and triphenylphosphine (305 mg, 1.16 mmol) in THF (5 ml). Purified by flash chromatography (Merck 9385 silica, EtOAc/isohexane (7/3)) to give the title compound (254 mg, 69%) as a colourless solid. 1H-NMR (300 MHz, CDCl3): delta=3.05 (m, 4H), 3.88 (m, 4H), 3.94 (dd, 1H), 4.14 (t, 1H), 4.47-4.62 (m, 2H), 5.01 (m, 1H), 6.00 (d, 1H), 6.94 (t, 1H), 7.15 (dd, 1H), 7.46 (d, 1H), 8.15 (d, 1H). MS: ESP+(M+H)+=364.
  • 6
  • [ 856866-72-3 ]
  • [ 5777-20-8 ]
  • [ 717116-80-8 ]
YieldReaction ConditionsOperation in experiment
51% With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20℃; for 12h;Inert atmosphere; To a solution of EtOH (200 mL), 10% NaOH solution (250 mL) and ethyl acetylenecarboxylate (20.7 mL, 204 mmol) was added hydroxylamine hydrochloride (17.0 g, 245 mmol). The reaction mixture was stirred at 30 C for 12 h. After the solution was cooled to room temperature, the pH was adjusted to 2 by addition of concentrated HCl solution. The mixture was extracted with EtOAc and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo to obtain isoxazol-3-ol (14.2 g, 82%). The crude product was used in the following step without further purification. To a solution of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxy methyl oxazolidin-2-one 11 (100 mg, 0.270 mmol) in THF (10 mL) was added isoxazol-3-ol (32.0 mg, 0.380 mmol) and triphenylphosphine (113 mg, 0.430 mmol). To the solution was added dropwise diethyl azodicarboxylate (640 muL, 0.410 mmol). After being stirred for 12 h, the reaction mixture was poured into water and extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. The residue was further purified by column chromatography to obtain the title compound (60 mg, 51%). 1H NMR (DMSO-d6): delta 8.92 (s, 1H), 8.69 (s, 1H), 8.20 (m, 2H), 7.75 (t, J = 8.8 Hz, 1H), 7.68 (d, J = 13.2 Hz, 1H), 7.45 (d, J = 8.8 Hz, 1H), 6.39 (s, 1H), 5.13 (m, 1H), 4.50 (m, 2H), 4.47 (s, 3H), 4.27 (t, J = 9.6 Hz, 1H), 3.98 (m, 1H). [M + H]+: 438.12.
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