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Chemical Structure| 57943-60-9 Chemical Structure| 57943-60-9

Structure of 57943-60-9

Chemical Structure| 57943-60-9

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Product Details of [ 57943-60-9 ]

CAS No. :57943-60-9
Formula : C8H10ClNO2
M.W : 187.62
SMILES Code : N=C(OC)C1=CC=C(O)C=C1.[H]Cl
MDL No. :MFCD00043248

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Application In Synthesis of [ 57943-60-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57943-60-9 ]

[ 57943-60-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 57943-60-9 ]
  • [ 347174-05-4 ]
  • [ 347165-36-0 ]
  • 2
  • [ 67-56-1 ]
  • [ 57943-60-9 ]
  • [ 347174-05-4 ]
  • [ 347165-36-0 ]
YieldReaction ConditionsOperation in experiment
72% EXAMPLE 3 Production of Ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)benzimidazole-5-carboxylate Ethyl 3-amino-4-cyclohexylaminobenzoate (130 g) obtained in Example 1, Step 3, and methyl 4-hydroxybenzimidate hydrochloride (139 g) were added to methyl alcohol (1500 ml), and the mixture was refluxed under heating for 4 hr. The reaction mixture was allowed to cool and the precipitated crystals were collected by filtration to give the title compound (131 g, yield 72%). 1H-NMR (300 MHz, CDCl3): 10.02 (1H, brs), 8.21 (1H, d, J=1.4 Hz), 7.93 (1H, d, J=8.6 Hz), 7.83 (1H, dd, J=8.6, 1.4 Hz), 7.48 (2H, d, J=8.6 Hz), 6.95 (2H, d, J=8.6 Hz), 4.39-4.25 (1H, m), 4.33 (1H, q, J=7.0 Hz), 2.35-2.18 (2H, m), 1.98-1.79 (4H, m), 1.70-1.60 (1H, m), 1.46-1.19 (3H, m), 1.35 (3H, t, J=7.0 Hz).
 

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