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Chemical Structure| 579510-29-5 Chemical Structure| 579510-29-5

Structure of 579510-29-5

Chemical Structure| 579510-29-5

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Product Details of [ 579510-29-5 ]

CAS No. :579510-29-5
Formula : C15H15NO3
M.W : 257.28
SMILES Code : O=C(OC)C1=CC=CC(NC2=CC=C(OC)C=C2)=C1
MDL No. :MFCD22690197

Safety of [ 579510-29-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H303-H315-H319-H335-H413
Precautionary Statements:P261-P264-P271-P273-P280-P302+P352-P304+P340+P312-P305+P351+P338-P312-P332+P313-P337+P313-P403+P233-P405-P501

Application In Synthesis of [ 579510-29-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 579510-29-5 ]

[ 579510-29-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 618-89-3 ]
  • [ 104-94-9 ]
  • [ 579510-29-5 ]
YieldReaction ConditionsOperation in experiment
93% With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 120℃;Inert atmosphere; To a solution of bromide (or triflate) (1 equiv) in toluene (0.1 M) was added aniline (1.2 equiv), Cs2CO3 (1.4 equiv) BINAP (0.08 equiv), and Pd(OAc)2 (0.05 equiv) at room temperature. The reaction mixture was allowed to stir at 120 C for 4-48 h. Once the reaction appeared to be complete by consumption of the bromide (or triflate) by TLC analysis, the mixture was allowed to cool to room temperature, diluted with EtOAc, washed with 2M aq HCl (2x), brine, and dried over sodium sulfate. The solution was concentrated, loaded on silica gel, and purified by silica gel chromatography.
 

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