[ CAS No. 580-15-4 ]

Name: 580-15-4|6-Aminoquinoline|98%
Brand: Ambeed
SKU: A177597
Price: 5.0 USD
Availability: InStock
Rating: 95 (22 reviews)

{[proInfo.proName]} ,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

Structure of 580-15-4 * Storage: {[proInfo.prStorage]}

Cart0 Bulk Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 88K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 580-15-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 580-15-4 ]

SDS

Alternatived Products of [ 580-15-4 ]

Product Details of [ 580-15-4 ]

CAS No. :	580-15-4	MDL No. :	MFCD00006803
Formula :	C₉H₈N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	144.17 g/mol	Pubchem ID :	11373
Synonyms :

Safety of [ 580-15-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313	UN#:	N/A
Hazard Statements:	H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 580-15-4 ]

Upstream synthesis route of [ 580-15-4 ]
Downstream synthetic route of [ 580-15-4 ]

[ 580-15-4 ] Synthesis Path-Upstream 1~5

1
[ 580-15-4 ]
[ 396-30-5 ]

Reference： [1] Journal of the American Chemical Society, 1949, vol. 71, p. 1785
[2] Patent: EP2172453, 2010, A1, . Location in patent: Page/Page column 10

2
[ 580-15-4 ]
[ 13327-31-6 ]

Yield	Reaction Conditions	Operation in experiment
79%	Stage #1: With trifluorormethanesulfonic acid; sodium nitrite In hexane; dimethyl sulfoxide at 5 - 20℃; for 1 h; Stage #2: With potassium iodide In hexane; water; dimethyl sulfoxide at 20℃; for 0.166667 h;	General procedure: To a solution of hexane (5 mL), DMSO (0.5 mL), and trifluoromethanesulfonicacid (0.54 mL, 6 mmol) at 5 °C were sequentially added thequinoline amine 4b or 4c (2 mmol) and NaNO2 (350 mg, 5 mmol) understirring, and the mixture was stirred for 10 min. The resultingmixture was then stirred for 50 min at r.t. until the starting aminehad been consumed as monitored by TLC. An emission of N2 bubbleswas not observed and the reaction solution gave the positive probeon diazonium salts with β-naphthol. Next, KI (2.4 mmol) in H2O (0.5mL) was added and the mixture was stirred 10 min at r.t. until evolutionof N2 bubbles ceased. In the case of 4b, the solid 3-iodoquinoline6 obtained was filtered, washed with H2O, and dried. In the case of 3c,the reaction mixture was poured into H2O and the oily product 7 was extracted with EtOAc (2 × 25 mL). The combined organic extractswere dried (Na2SO4), filtered, and the solvent was removed under reducedpressure on a rotary evaporator. The product 7 was purified bysilica gel flash chromatography (eluent: CH2Cl2).

Reference： [1] Synthesis (Germany), 2016, vol. 48, # 2, p. 256 - 262
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 16, p. 5836 - 5857

3
[ 580-15-4 ]
[ 4964-71-0 ]

Reference： [1] Journal fuer Praktische Chemie (Leipzig), 1906, vol. <2> 73, p. 249

4
[ 580-15-4 ]
[ 108-24-7 ]
[ 22433-76-7 ]

Reference： [1] Journal of Organic Chemistry, 2017, vol. 82, # 2, p. 1114 - 1126
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 5, p. 847 - 858
[3] Journal of the Chemical Society. Perkin Transactions 1, 2001, # 9, p. 955 - 977
[4] Justus Liebigs Annalen der Chemie, 1900, vol. 310, p. 75,84
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 17, p. 4533 - 4536

5
[ 580-15-4 ]
[ 176967-80-9 ]

Reference： [1] Journal fuer Praktische Chemie (Leipzig), 1906, vol. <2> 73, p. 249

[ 580-15-4 ] Synthesis Path-Downstream 1~25

1
[ 580-15-4 ]
[ 14394-60-6 ]
<i>N</i>²-[6]quinolyl-6-methyl-pyrimidine-2,4-diyldiamine [ No CAS ]

Reference： [1]Journal of the Chemical Society,1953,p. 50,55

2
[ 580-15-4 ]
[ 14527-26-5 ]
[ 109682-36-2 ]

Reference： [1]Journal of the Chemical Society,1949,p. 1257

3
[ 580-15-4 ]
[ 396-30-5 ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of 6-aminoquinoline (1.0 g) in 42percent tetrafluoroboric acid (5 ml), sodium nitrite (527 mg) was added under ice cooling and stirred at the same temperature for 1 hour. After addition of diethyl ether:ethyl acetate = 1:1 (10 ml), the reaction mixture was decanted and the precipitate was dried. To the dried product, toluene (20 ml) was added and heated under reflux for 2 hours. The reaction mixture was decanted, and the resulting residue was dissolved in 1M aqueous hydrochloric acid and alkalized with saturated aqueous sodium carbonate. Insoluble materials were filtered off and the filtrate was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then filtered to remove the desiccant, followed by distilling off the solvent under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluting solvent: n-hexane:diethyl ether = 4:1 to 1:1) to give 6-fluoroquinoline (273 mg) as an orange-colored oil. To a solution of 6-fluoroquinoline thus obtained (273 mg) in methanol (50 ml), 10percent palladium on activated carbon (50 mg) was added and stirred overnight under a hydrogen atmosphere (60 psi) at room temperature. After the reaction mixture was filtered, the solvent was distilled off under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluting solvent: n-hexane:ethyl acetate = 10:1 to 4:1) to give the titled compound, i.e., 6-fluoro-1,2,3,4-tetrahydroquinoline (172 mg) as a light-brown oil. 1H NMR (300 MHz, CHLOROFORM-D) delta 1.86-1.97 (m, 2 H), 2.74 (t, J=6.5 Hz, 2 H), 3.23-3.30 (m, 2 H), 3.69 (brs, 1 H), 6.35-6.45 (m, 1 H), 6.62-6.72 (m, 2 H).

Reference： [1]Journal of the American Chemical Society,1949,vol. 71,p. 1785
[2]Patent: EP2172453,2010,A1 .Location in patent: Page/Page column 10

4
[ 580-15-4 ]
[ 23395-72-4 ]

Reference： [1]Journal of the Chemical Society,1943,p. 419

5
[ 580-16-5 ]
[ 7462-74-0 ]
[ 580-15-4 ]
2-Hydroxy-2-methyl-N-quinolin-6-yl-propionamide [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1997,vol. 34,p. 1857 - 1860

6
N.N'-di-<quinonyl-(6)>-thiourea [ No CAS ]
[ 580-15-4 ]
[ 23395-72-4 ]

Reference： [1]Patent: DE259363,
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 11,p. 203

7
[ 188417-26-7 ]
[ 493-72-1 ]
[ 580-15-4 ]
2-ethoxy-4-(11-oxo-9-phenyl-7,8,9,10,11,12-hexahydrobenzo[b][4,7]phenanthrolin-12-yl)phenyl isobutyrate [ No CAS ]

Reference： [1]Russian Journal of General Chemistry,2005,vol. 75,p. 1562 - 1565

8
[ 580-15-4 ]
[ 57709-61-2 ]
[ 929895-50-1 ]

Reference： [1]Journal of the American Chemical Society,2007,vol. 129,p. 1856 - 1857

9
[ 580-15-4 ]
[ 4479-74-7 ]
[ 929895-48-7 ]

Reference： [1]Journal of the American Chemical Society,2007,vol. 129,p. 1856 - 1857

10
[ 580-15-4 ]
[ 176967-80-9 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1906,vol. <2> 73,p. 249

11
[ 580-16-5 ]
Cs₂ CO₃ [ No CAS ]
[ 7462-74-0 ]
[ 580-15-4 ]

Yield	Reaction Conditions	Operation in experiment
	With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; NaH; In 1,4-dioxane;	Preparation of 6-aminoquinoline To a solution of 6-hydroxyquinoline (537 mg, 3.70 mmol) in dioxane (20 mL) was added NaH (Aldrich, dry, 300 mg, 12.2 mmol) and Cs2 CO3 (4.00 g, 12.2 mmol). The resulting mixture was stirred at room temperature for about 30 minutes, then 2-bromo-2-methyl-propanamide (2.03 g, 12.2 mmol) was added and the resulting mixture was stirred at reflux for 16 h. After the reflux period, NMP (20 mL), DMPU (2 mL), and NaH (Aldrich, dry, 100 mg, 4.07 mmol) were added. The resulting mixture was stirred at 150 C. for 72 h. The reaction was cooled to room temp., and partitioned between water (50 mL) and EtOAc (100 mL). The aqueous layer was extracted with EtOAc (100 mL) and the combined organics washed with water (2*50 mL), dried (Na2 SO4), and concentrated to about 3 g of material. The brown oil was distilled by Kugelrohr to remove residual NMP and DMPU, then chromatographed on silica (200 mL, 4 cm diam. column), eluding with 70:30:1 EtOAc/hexane/NEt3 to obtain 6-aminoquinoline as a brown solid (210 mg, 1.45 mmol, 39.2% yield).: mp 111-113 C. (lit. 116 C., Sykes, W. O., Journal of the Chemical Society, 1956, 3087); 1 H NMR (300 MHz, CDCl3) delta8.66 (dd, 1 H, J=4.27, 1.63 Hz), 7.93-7.87 (m, 2 H), 7.26 (dd, 1 H, J=8.24, 4.23 Hz), 7.16 (dd, 1 H, J=9.05, 2.69), 6.90 (d, 1 H, J=2.74), 3.97 (br s, 2 H, NH2); 13 C NMR (75 MHz, CDCl3) delta146.8, 144.5, 143.5, 133.7, 130.6, 129.7, 121.5, 121.4, 107.4; MS (CI/NH3) 145.

Reference： [1]Patent: US6034241,2000,A

12
[ 580-15-4 ]
[ 102308-97-4 ]
[ 530-62-1 ]
N-(1-Methyl-5-indolyl)-N'-(6-quinolyl)-urea hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	In dichloromethane; water; N,N-dimethyl-formamide;	Example 10 N-(1-Methyl-5-indolyl)-N'-(6-quinolyl)-urea hydrochloride (E10) A stirred suspension of carbonyl diimidazole (0.34 g, 2.1 mM) in dry dichloromethane (5 ml) was treated with a solution of 5-amino 1-methyl indole (D2, 0.29 g, 2 mM) in dry dichloromethane (5 ml). After 0.25 h, the reaction mixture was evaporated to dryness and the residue dissolved in DMF (10 ml). 6-Aminoquinoline (0.32 g, 2.2 mM) was added and the reaction mixture heated to 90 C. for 1 h then cooled and added to water (200 ml) with vigorous stirring. The precipitate was filtered, dried and recrystallized from ethanol, affording the product as a white solid (0.32 g, 51%).

Reference： [1]Patent: US5508288,1996,A

13
[ 872-50-4 ]
[ 580-16-5 ]
[ 7462-74-0 ]
[ 580-15-4 ]

Yield	Reaction Conditions	Operation in experiment
	With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; NaH; caesium carbonate; In 1,4-dioxane;	Preparation of 6-aminoquinoline. To a solution of 6-hydroxyquinoline (537 mg, 3.70 mmol) in dioxane (20 mL) was added NaH (Aldrich, dry, 300 mg, 12.2 mmol) and Cs2CO3 (4.00 g, 12.2 mmol). The resulting mixture was stirred at room temperature for about 30 minutes, then 2-bromo-2-methyl-propanamide (2.03 g, 12.2 mmol) was added and the resulting mixture was stirred at reflux for 16 h. After the reflux period, NMP (20 mL), DMPU (2 mL), and NaH (Aldrich, dry, 100 mg, 4.07 mmol) were added. The resulting mixture was stirred at 150 C for 72 h. The reaction was cooled to room temp., and partitioned between water (50 mL) and EtOAc (100 mL). The aqueous layer was extracted with EtOAc (100 mL) and the combined organics washed with water (2 x 50 mL), dried (Na2SO4), and concentrated to about 3 g of material. The brown oil was distilled by Kugelrohr to remove residual NMP and DMPU, then chromatographed on silica (200 mL, 4 cm diam. column), eluding with 70:30:1 EtOAc/hexane/NEt3 to obtain 6-aminoquinoline as a brown solid (210 mg, 1.45 mmol, 39.2 % yield).: mp 111-113 C (lit. 116 C, Sykes, W.O., Journal of the Chemical Society, 1956, 3087); 1H NMR (300 MHz, CDCl3) delta 8.66 (dd, 1 H, J = 4.27, 1.63 Hz), 7.93-7.87 (m, 2 H), 7.26 (dd, 1 H, J = 8.24, 4.23 Hz), 7.16 (dd, 1 H, J = 9.05, 2.69), 6.90 (d, 1 H, J = 2.74), 3.97 (br s, 2 H, NH2); 13C NMR (75 MHz, CDCl3) delta 146.8, 144.5, 143.5, 133.7, 130.6, 129.7, 121.5, 121.4, 107.4; MS (CI/NH3) 145.

Reference： [1]Patent: EP944600,2002,B1

14
[ 580-15-4 ]
[ 24415-66-5 ]
(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)quinolin-6-ylamine [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2008,vol. 51,p. 3649 - 3653

15
[ 612-57-7 ]
[ 580-15-4 ]

Reference： [1]Angewandte Chemie - International Edition,2010,vol. 49,p. 4071 - 4074
[2]Organic Letters,2015,vol. 17,p. 5934 - 5937
[3]Chemistry - A European Journal,2013,vol. 19,p. 2131 - 2141
[4]Organic Letters,2013,vol. 15,p. 3734 - 3737
[5]Organic Letters,2014,vol. 16,p. 4388 - 4391
[6]Angewandte Chemie - International Edition,2015,vol. 54,p. 3773 - 3777
Angew. Chem.,2015,vol. 127,p. 3844 - 3848,5
[7]Angewandte Chemie - International Edition,2015,vol. 54,p. 3768 - 3772
Angew. Chem.,2015,vol. 127,p. 3839 - 3843,5

16
[ 580-15-4 ]
[ 24424-99-5 ]
[ 120205-50-7 ]
6-(tert-butoxycarbonyl)aminoquinoline [ No CAS ]
[ 1307229-35-1 ]

Yield	Reaction Conditions	Operation in experiment
		jV-Boc-Dap-6-aminoquinoIine (14). Method A: To a stirring solution of Boc-Dap1 (6, 87.2 mg; 0.3 mmol) in DMF (2 mL) and pyridine (0.1 mL) was added Boc20 (0.183 g; 0.84 mmol). After 10 min, 6-aminoquinoline (6-AQ; 50.4 mg; 0.35 mmol) was added to the solution, and stirring was continued for 64 h, at which time starting material was still present. Solvent was removed from the mixture, and the residue was fractionated by column chromatography in hexane-acetone (5:1 to 2:1 gradient). The first fractions to elute contained Boc-6-AQ (35 mg): NMR (CDCI3, 300 MHz) delta 8.79 (1H, dd, J= 4.5, 1.5 Hz), 8.01-8.12 (3H, m), 7.48 (1H, dd, J = 9, 2.7 Hz), 7.36 (1H, dd, J= 7.1, 4.2 Hz), 7.03 (1H, br s), 1.55 (9H, s). [0179] Following the elution of the remaining Boc-Dap (6), compound 14 (29.7 mg, 0.07 mmol, 23% yield, or 28% based on 14.9-mg recovery of 6-AQ) was collected: NMR (CDC13, 300 MHz) S 8.82 (2H, m), 8.45 (1H, br s), 8.11 (1H, d, J= 8.1 Hz), 8.04 (1H, d, J= 9.3 Hz), 7.72 (1H, br), 7.37 (1H, dd, J= 8.4, 4.2 Hz), 4.15-3.90 (2H, m, NCH, OCH), 3.55 (3H, s, OC¾), 3.43 (m, 1H), 3.27 (m, 1H), 2.72 (1H, m), 2.06-1.76 (4H, m), 1.50 (9H, s), 1.39 (3H, m); MS (APCI+) mlz 414.2408 [M + H]+ (calcd for C23H32N3O4, 414.2393).

Reference： [1]Journal of Natural Products,2011,vol. 74,p. 962 - 968
[2]Patent: WO2012/135440,2012,A1 .Location in patent: Page/Page column 43

17
[ 580-15-4 ]
[ 13327-31-6 ]

Yield	Reaction Conditions	Operation in experiment
79%		General procedure: To a solution of hexane (5 mL), DMSO (0.5 mL), and trifluoromethanesulfonicacid (0.54 mL, 6 mmol) at 5 C were sequentially added thequinoline amine 4b or 4c (2 mmol) and NaNO2 (350 mg, 5 mmol) understirring, and the mixture was stirred for 10 min. The resultingmixture was then stirred for 50 min at r.t. until the starting aminehad been consumed as monitored by TLC. An emission of N2 bubbleswas not observed and the reaction solution gave the positive probeon diazonium salts with beta-naphthol. Next, KI (2.4 mmol) in H2O (0.5mL) was added and the mixture was stirred 10 min at r.t. until evolutionof N2 bubbles ceased. In the case of 4b, the solid 3-iodoquinoline6 obtained was filtered, washed with H2O, and dried. In the case of 3c,the reaction mixture was poured into H2O and the oily product 7 was extracted with EtOAc (2 × 25 mL). The combined organic extractswere dried (Na2SO4), filtered, and the solvent was removed under reducedpressure on a rotary evaporator. The product 7 was purified bysilica gel flash chromatography (eluent: CH2Cl2).

Reference： [1]Synthesis,2016,vol. 48,p. 256 - 262
[2]Journal of Medicinal Chemistry,2011,vol. 54,p. 5836 - 5857

18
[ 580-15-4 ]
[ 120205-50-7 ]
Dap-6-aminoquinoline trifluoroacetate [ No CAS ]

Reference： [1]Patent: WO2012/135440,2012,A1

19
[ 580-15-4 ]
[ 4489-34-3 ]
N-[6-chloro-2-(methylsulfonyl)pyrimidin-4-yl]isoquinolin-6-amine [ No CAS ]

Reference： [1]Synthesis,2013,vol. 45,p. 1764 - 1784

20
[ 580-15-4 ]
[ 35578-47-3 ]
C₁₅H₁₉N₂O₆Pol [ No CAS ]
C₃₈H₃₂Br₂N₅O₅Pol [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 9271 - 9274,4
Angew. Chem.,2014,vol. 126,p. 9425 - 9428,4
Angewandte Chemie,2014,vol. 126,p. 9425 - 9428,4

21
[ 580-15-4 ]
[ 5521-55-1 ]
5-methylpyrazine-2-carboxylic acid quinolin-6-ylamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20℃; for 24h;	General procedure: To a solution of the corresponding acid (1.0 to 2.0 equiv) and amine (1.0 equiv) in CH2CI2 was added DIPEA (3.0 equiv). HBTU (2.0 equiv) was added at 0 C. The resulting mixture was stirred at r.t. for 24 h. The reaction mixture was diluted with CH2CI2 and washed with water. The organic layer was separated and dried over anhydrous Na2SO4. The solution was concentrated to give a crude product, which was purified with a silica gel column (EtOAc/hexane) to obtain the desired product.

Reference： [1]Patent: WO2016/187544,2016,A1 .Location in patent: Page/Page column 82

22
[ 580-15-4 ]
[ 2498-50-2 ]
(E)-4-((6-aminoquinolin-5-yl)diazenyl)benzimidamide [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2017,vol. 8,p. 492 - 497

23
[ 13327-31-6 ]
[ 580-15-4 ]

Reference： [1]Organic Letters,2017,vol. 19,p. 2809 - 2812
[2]Organic and Biomolecular Chemistry,2019,vol. 17,p. 1791 - 1795

24
[ 580-15-4 ]
[ 10320-42-0 ]
N-(5-nitropyrimidin-2-yl)quinolin-6-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	In acetonitrile;Inert atmosphere;	The first step: a vacuum 50mL reaction bottle is vacuumed three times,After adding quinoline-6-amine (144 mg, 1.0 mmol, 1.0 equiv) to the reaction jar,Add 10.0 mL of dried acetonitrile and stir until quinoline-6-amine is completely dissolved.Then <strong>[10320-42-0]2-chloro-5-nitropyrimidine</strong> (0.1593 g, 1.0 mmol, 1.0 equiv) was added to the reaction flask.The entire mixture was reacted under nitrogen pressure for 4-5 hours.The reaction detects the progress of the reaction by TLC.The reaction can be stopped if it is detected that all the aniline is completely reacted.The experimental treatment is to drain the solution in the reaction;The solute in the reaction flask was dissolved with ethyl acetate.And transferred to a 100 mL round bottom flask,Add 2 mL (200-300 mesh) of silica gel to the round bottom flask for spin-drying (petroleum ether and acetic acid B)Ester) over silica gel in the column.The intermediate product was pale yellow crystals N-(5-nitropyrimidin-2-yl)quinolin-6-amine (240 mg, 90% yield).

Reference： [1]Patent: CN108148005,2018,A .Location in patent: Paragraph 0181; 0181; 0182
[2]Organometallics,2019,vol. 38,p. 2084 - 2091

25
[ 91-22-5 ]
[ 580-19-8 ]
[ 580-15-4 ]
[ 578-66-5 ]
[ 611-34-7 ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 532 - 536
Angew. Chem.,2019,vol. 131,p. 542 - 546,5

Related Products

Historical Records

Related Functional Groups of
[ 580-15-4 ]

Amines

[ 129844-69-5 ]

6-Methylquinolin-7-amine

Similarity: 0.96

[ 611-34-7 ]

Quinolin-5-amine

Similarity: 0.96

[ 578-68-7 ]

4-Aminoquinoline

Similarity: 0.96

[ 1246556-01-3 ]

Quinolin-7-amine hydrochloride

Similarity: 0.96

[ 578-66-5 ]

8-Aminoquinoline

Similarity: 0.92

Related Parent Nucleus of
[ 580-15-4 ]

Quinolines

[ 612-58-8 ]

3-Methylquinoline

Similarity: 0.96

[ 129844-69-5 ]

6-Methylquinolin-7-amine

Similarity: 0.96

[ 611-34-7 ]

Quinolin-5-amine

Similarity: 0.96

[ 578-68-7 ]

4-Aminoquinoline

Similarity: 0.96

[ 1246556-01-3 ]

Quinolin-7-amine hydrochloride

Similarity: 0.96

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 580-15-4 ]

Quality Control of [ 580-15-4 ]

Related Doc. of [ 580-15-4 ]

Product Details of [ 580-15-4 ]

Safety of [ 580-15-4 ]

Application In Synthesis of [ 580-15-4 ]

[ 580-15-4 ] Synthesis Path-Upstream 1~5

[ 580-15-4 ] Synthesis Path-Downstream 1~25

Related Functional Groups of [ 580-15-4 ]

Amines

Related Parent Nucleus of [ 580-15-4 ]

Quinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 580-15-4 ]

Related Parent Nucleus of
[ 580-15-4 ]