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[ CAS No. 58331-99-0 ] {[proInfo.proName]}

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Chemical Structure| 58331-99-0
Chemical Structure| 58331-99-0
Structure of 58331-99-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 58331-99-0 ]

CAS No. :58331-99-0 MDL No. :MFCD22199275
Formula : C10H6N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 186.17 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 58331-99-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 58331-99-0 ]

[ 58331-99-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 54335-33-0 ]
  • copper(l) cyanide [ No CAS ]
  • [ 58331-99-0 ]
YieldReaction ConditionsOperation in experiment
72.8% With sodium iodide; In N,N-dimethyl-formamide; at 160℃;Inert atmosphere; Step 1: To a 2 L round-bottom flask, 2,4-dibromobenzoicacid (250 g, 0.90 mol) in MeOH (2 L) and concentrated H2SO4 (18.4 g, 0.19 mol) were added. The mixture was refluxed overnight before cooled to room temperature. The resulting precipitate was then filtered, washed with cold methanol and dried under vacuum. It yielded 213.6 g <strong>[54335-33-0]methyl 2,4-dibromobenzoate</strong> as a yellow solid. To a 2 L round-bottom flask was added 2,4-dibromobenzoate (200.7 g, 0.69 mol) in 1 L dry DMF. CuCN (123.8 g, 1.38 mol) and NaI (22.8 g, 0.15 mol) were introduced next. The mixture was stirred overnight at 160 °C under nitrogen atmosphere. After the reaction was complete, it was extracted with ethyl acetate (500 mL × 3),washed with water (500 mL) and purified over silica gel (PE/EtOAc = 5/1) to give 93.5 g methyl 2,4-dicyanobenzoate as a brown solid (yield: 72.8 percent).
  • 2
  • [ 611-00-7 ]
  • [ 58331-99-0 ]
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