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[ CAS No. 58481-01-9 ]

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Chemical Structure| 58481-01-9
Chemical Structure| 58481-01-9
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Product Details of [ 58481-01-9 ]

CAS No. :58481-01-9 MDL No. :MFCD03791263
Formula : C6H8N4O Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :152.15 g/mol Pubchem ID :-
Synonyms :

Safety of [ 58481-01-9 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 58481-01-9 ]

  • Downstream synthetic route of [ 58481-01-9 ]

[ 58481-01-9 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 58481-01-9 ]
  • [ 14527-26-5 ]
  • [ 77314-44-4 ]
  • 2
  • [ 13362-30-6 ]
  • *or 2-amino-isonicotinic acid methyl ester [ No CAS ]
  • [ 58481-01-9 ]
  • 3
  • [ 6937-03-7 ]
  • [ 58481-01-9 ]
YieldReaction ConditionsOperation in experiment
90% With hydrazine hydrate In methanol for 3h; Heating;
With hydrazine hydrate In ethanol Reflux;
With hydrazine hydrate In methanol for 3h; Reflux; 1 Intermediate 10: 4- (4-isopropyl-4H-1,1,4-triazol-3-yl) pyridin-2-amine (ZTB-81) Step 1: Add raw material methyl 2-aminoisonicotinate (4.32 g, 28.4 mmol) to a 100 mL reaction flask, add 50 mL of MeOH to dissolve the reaction, and add hydrazine hydrate (2.84 g, 56.8 mmol).Reflux for 3h.After the reaction was completed, the mixture was cooled to room temperature, a solid was precipitated, and the solid was washed with ethyl acetate (after 200 ml) and dried to obtain 3.72 g of a ZTB-80 compound.GainThe obtained ZTB-80 crude was directly used in the next reaction.
  • 4
  • [ 13362-30-6 ]
  • [ 58481-01-9 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; In ethanol; for 5h;Reflux; General procedure: For the synthesis of substituted benzoylhydrazines, a mixture of corresponding esters (20 mmol), 85percent hydrazine hydrate (20 mmol) in ethanol (35 ml) was heated to reflux for 5 h. After that, the solution was poured into ice-water. The precipitate was filtered and crystallized from ethanol.
Historical Records

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