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Chemical Structure| 586-22-1 Chemical Structure| 586-22-1

Structure of 586-22-1

Chemical Structure| 586-22-1

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Product Details of [ 586-22-1 ]

CAS No. :586-22-1
Formula : C10H11FO2
M.W : 182.19
SMILES Code : CCC(C1=CC=C(OC)C(F)=C1)=O
MDL No. :MFCD01814881
InChI Key :SQXQCZIODUUTAD-UHFFFAOYSA-N
Pubchem ID :276284

Safety of [ 586-22-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 586-22-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 586-22-1 ]

[ 586-22-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 331-62-4 ]
  • [ 925-90-6 ]
  • [ 586-22-1 ]
YieldReaction ConditionsOperation in experiment
57% In tetrahydrofuran; diethyl ether; at 0 - 20℃; To a solution of <strong>[331-62-4]3-fluoro-4-methoxybenzonitrile</strong> (350 mg, 2.32 mmol) in 15 mL anhydrous THF was added ethylmagnesium bromide (1 M in Et20, 4.63 mL) at 0 °C. The reaction mixture was stirred at rt overnight, then quenched with sat. NaHC(, extracted with EtOAc, washed with brine, dried and evaporated. The residue was purified by column chromatography (eluent: petroleum ether/EtOAc = 5/1) over silica gel to give the product (239 mg, 57percent yield) as a yellow solid.
 

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