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Chemical Structure| 59-30-3 Chemical Structure| 59-30-3
Chemical Structure| 59-30-3

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Folic acid (Vitamin B9) is an orally active essential nutrient from the vitamin B group with antidepressant effects. It reduces the risk of neural tube defects in newborns and is used in studies of megaloblastic anemia and macrocytic anemia caused by folate deficiency.

Synonyms: Vitamin B9; Vitamin M; Vitamin Be

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Product Citations

Product Citations

Shameer M. Kondengadan ; Shubham Bansal ; Xiaoxiao Yang ; Binghe Wang ;

Abstract: Carbon monoxide (CO) is an endogenous produced molecule and has shown efficacy in animal models of inflammation, organ injury, colitis and cancer metastasis. Because of its gaseous nature, there is a need for developing efficient CO delivery approaches, especially those capable of targeted delivery. In this study, we aim to take advantage of a previously reported approach of enrichment-triggered prodrug activation to achieve targeted delivery by targeting the folate receptor. The general idea is to exploit folate receptor-mediated enrichment as a way to accelerate a biomolecular Diels-Alder reaction for prodrug activation. In doing so, we first need to find ways to tune the reaction kinetics in order to ensure minimal rection without enrichment and optimal activation upon enrichment. In this feasibility study, we synthesized two diene-dienophile pairs and studied their reaction kinetics and ability to target the folate receptor. We found that folate conjugation significantly affects the reaction kinetics of the original diene-dienophile pairs. Such information will be very useful in future designs of similar targeted approaches of CO delivery.

Keywords: Enrichment triggered delivery ; Carbon Monoxide ; Folate conjugate ; Reaction kinetics ; Diels-Alder reaction

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Product Details of Folic acid

CAS No. :59-30-3
Formula : C19H19N7O6
M.W : 441.40
SMILES Code : O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O
Synonyms :
Vitamin B9; Vitamin M; Vitamin Be
MDL No. :MFCD00079305
InChI Key :OVBPIULPVIDEAO-LBPRGKRZSA-N
Pubchem ID :135398658

Safety of Folic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Folic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59-30-3 ]

[ 59-30-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 188497-71-4 ]
  • folic acid disodium salt [ No CAS ]
  • [ 68-04-2 ]
  • [ 59-30-3 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; Preparation A An aqueous solution of folic acid, dihydrofolic acid and citric acid was prepared using sodium hydroxide solution. The pH value of the solution was 10.4. 100 g solution contained 16 mmol folic acid disodium salt, 1 mmol dihydrofolic acid, sodium salt, and 5 mmol tri<strong>[68-04-2]sodium citrate</strong>.
  • 2
  • [ 29390-67-8 ]
  • [ 59-30-3 ]
  • βCyD6-FAα [ No CAS ]
  • βCyD6-FAγ [ No CAS ]
 

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