[ CAS No. 59019-85-1 ] {[proInfo.proName]}

Name: 59019-85-1|5-Methoxythiazol-2-amine|97%
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SKU: A360919
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Quality Control of [ 59019-85-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 59019-85-1 ]

SDS Specification

Alternatived Products of [ 59019-85-1 ]

Product Details of [ 59019-85-1 ]

CAS No. :	59019-85-1	MDL No. :	MFCD01630757
Formula :	C₄H₆N₂OS	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OZNOHWKQLWLLAG-UHFFFAOYSA-N
M.W :	130.17	Pubchem ID :	20316283
Synonyms :

Calculated chemistry of [ 59019-85-1 ]

Physicochemical Properties

Num. heavy atoms :	8
Num. arom. heavy atoms :	5
Fraction Csp3 :	0.25
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	33.01
TPSA :	76.38 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.45 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.39
Log Po/w (XLOGP3) :	0.91
Log Po/w (WLOGP) :	0.74
Log Po/w (MLOGP) :	-0.81
Log Po/w (SILICOS-IT) :	1.44
Consensus Log Po/w :	0.73

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.62
Solubility :	3.15 mg/ml ; 0.0242 mol/l
Class :	Very soluble
Log S (Ali) :	-2.1
Solubility :	1.04 mg/ml ; 0.00795 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.03
Solubility :	12.3 mg/ml ; 0.0942 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.77

Safety of [ 59019-85-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P301+P312+P330	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 59019-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 59019-85-1 ]

[ 59019-85-1 ] Synthesis Path-Downstream 1~13

1
[ 41663-73-4 ]
[ 124-41-4 ]
[ 59019-85-1 ]

Reference： [1]Tetrahedron Letters,1976,p. 201 - 202

2
[ 3034-22-8 ]
[ 124-41-4 ]
[ 59019-85-1 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; at 17 - 25℃; for 12h;	The 2-amino-5-methoxythiazole used as a starting material was prepared as follows :- Sodium methoxide (0.724 g) was added to a solution of 2-amino-5-bromothiazole(0.6 g) in methanol (6 ml) and the resultant mixture was stirred at ambient temperature for 12 hours. The mixture was evaporated and the residue was purified by column chromatography on silica using increasingly polar mixtures of methylene chloride and ethyl acetate as eluent. There was thus obtained the required starting material (0.132 g); 1HNMR: (CDCl3) 3.82 (s, 3H), 4.53 (br s, 2H), 6.41 (s, IH).

Reference： [1]Tetrahedron Letters,1976,p. 201 - 202
[2]Patent: WO2006/40520,2006,A1 .Location in patent: Page/Page column 163

3
[ 122-01-0 ]
[ 59019-85-1 ]
2-(4-Chlorobenzoylamino)-5-methoxythiazole [ No CAS ]

Reference： [1]Collection of Czechoslovak Chemical Communications,1999,vol. 64,p. 299 - 312

4
[ 96568-04-6 ]
[ 122-51-0 ]
[ 59019-85-1 ]
(Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-(5-methoxy-thiazol-2-ylamino)-acrylic acid ethyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 5564 - 5575

5
[ 67-56-1 ]
[ 3034-22-8 ]
[ 124-41-4 ]
[ 59019-85-1 ]

Yield	Reaction Conditions	Operation in experiment
	at 17 - 25℃; for 12h;	The 2-amino-5-methoxythiazole used as a starting material was prepared as follows :- Sodium methoxide (0.724 g) was added to a solution of 2-amino-5-bromothiazole (0.6 g) in methanol (6 ml) and the resultant mixture was stirred at ambient temperature for12 hours. The mixture was evaporated and the residue was purified by column chromatography on silica using increasingly polar mixtures of methylene chloride and ethyl acetate as eluent. There was thus obtained the required starting material (0.132 g); 1H NMR:(CDCl3) 3.82 (s, 3H), 4.53 (br s, 2H), 6.41 (s, IH).
	at 50℃; for 14h;	The commeiciaily available HBr salt of 5-bromothiazol-2~arnine (Aldrich, 5 0 g, 19 mmol) was converted to its free base To a solution of 5-bromothiazol-2-amine, in methanol (100 mL) was added sodium methoxide (0 5M in methanol, 36 mL, 18 mmol) The reaction mixture was stirred at 50 0C for 14 hours, cooled and concentrated The residue was purified by column chromatography using an Analogix.(R). Intelliflash280 .(TM). (SiO2, 0-100 percent ethyl acetate in hexanes) to afford the title compound MS (ESf) m/z 131 (M+H)+

Reference： [1]Patent: WO2007/99317,2007,A1 .Location in patent: Page/Page column 100
[2]Patent: WO2007/140439,2007,A2 .Location in patent: Page/Page column 131

6
[ 1158210-56-0 ]
[ 59019-85-1 ]
[ 1158212-40-8 ]

Yield	Reaction Conditions	Operation in experiment
		Example 97 5-(2-Methoxyethyl)-N-[(5-methoxy-1,3-thiazol-2-yl)carbamoyl]-4-methylthiophene-2-sulfonamide The title compound was prepared in analogy to the procedure described in Example 54 starting from 5-(2-methoxy-ethyl)-4-methyl-thiophene-2-sulfonic acid amide and <strong>[59019-85-1]2-amino-5-methoxythiazole</strong> to obtain the desired compound as a white solid. MS (ISN): m/e 390.0 (M-H)-

Reference： [1]Patent: US2009/143448,2009,A1

7
[ 1143510-49-9 ]
[ 59019-85-1 ]
[ 1328983-38-5 ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20℃;	To a mixture of 2-(4-cyclopropanesulfonylphenyl)-2-(2,4-difluorophenoxy)acetic acid (0.1 g, 0.27 mmol), <strong>[59019-85-1]5-methoxy-thiazol-2-ylamine</strong> (0.042 g, 0.33 mmol), HOBt (0.044 g, 0.33 mmol), and EDCI (0.062 g, 0.33 mmol), in DMF (10 mL), was added N-methyl morpholine (0.034 g, 0.33 mmom). The resulting mixture was stirred at room temperature overnight followed by dilution with DCM. The reaction mixture was poured into water; organic layer was washed with water, brine, dried over sodium sulfate, and the organic solvent evaporated to get a residue which was purified by column chromatoghaphy using 40-50% ethylacetate in hexane as eluent to provide the title compound (0.045 g). 1H NMR (DMSO-d6, 400 MHz): delta 1.02-1.08 (m, 2H), 1.09-1.15 (m, 2H), 2.82-2.92 (m, 1H), 3.82 (s, 3H), 6.15 (s, 1H), 6.89 (s, 1H), 7.04-7.12 (m, 2H), 7.36-7.40 (m, 1H), 7.87 (d, J=8.4 Hz, 2H), 7.99 (d, J=8.4 Hz, 2H). MS (EI) m/z: 480.9 (M+1).

Reference： [1]Patent: US2010/310493,2010,A1 .Location in patent: Page/Page column 34

8
2-[1-(4-fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetic acid [ No CAS ]
[ 59019-85-1 ]
2-[1-(4-fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(5-methoxy-1,3-thiazol-2-yl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
8%		b) 2-[1-(4-Fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(5-methoxy-1,3-thiazol-2-yl)acetamide (example 88). [0274] Oxalyl chloride (66 muL; 0.75 mmol; 2.5 eq), followed by dimethylformamide (catalytic amount) was added to a solution of 2-[1-(4-fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetic acid (1-10) (120 mg; 0.30 mmol; 1 eq) in dichloromethane (6 mL). The reaction mixture was stirred at room temperature for 1 hour and 30 minutes. Pyridine (75 muL; 1.2 mmol; 4 eq) and <strong>[59019-85-1]5-methoxy-1,3-thiazol-2-amine</strong> (1-48) (58.2 mg; 0.44 mmol; 1.5 eq) were added. The reaction mixture was stirred at room temperature for 2 days. Ammonium chloride and ethyl acetate (20 mL) were added and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with saturated sodium chloride (3 x 15 mL), dried over sodium sulfate, filtered and concentrated to dryness. The crude was purified by preparative HPLC and the title compound 2-[1-(4-fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(5-methoxy-1,3-thiazol-2-yl)acetamide was obtained in 8% yield (12 mg) as a white powder. 1H-NMR (DMSO-d6): delta (ppm) 2.78 (m, 1H), 2.85 (m, 1H), 3.16 (d, 1H), 3.33 (m, 1H), 3.63 (m, 1H), 3.72 (s, 3H), 3.85 (s, 3H), 4.10 (m, 1H), 4.81 (m, 1H), 6.83 (m, 3H), 7.15 (d, 2H), 7.39 (m, 4H), 12.14 (s, 1H); MS (ESI+): m/z = 514.8 [M+H]+.
8%		b) 2-ri-(4-Fluorophenyl)-3-r2-(4-methoxyphenyl)ethyll-5-oxo-2- sulfanylideneimidazolidin-4-yll-N-(5-methoxy-l,3-thiazol-2-yl)acetamide (example 88). Oxalyl chloride (66 mu; 0.75 mmol; 2.5 eq), followed by dimethylformamide (catalytic amount) was added to a solution of 2-[l-(4-fluorophenyl)-3-[2-(4- methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetic acid (I- 10) (120 mg; 0.30 mmol; 1 eq) in dichloromethane (6 mL). The reaction mixture was stirred at room temperature for 1 hour and 30 minutes. Pyridine (75 mu; 1.2 mmol; 4 eq) and 5-methoxy-l,3-thiazol-2-amine (1-48) (58.2 mg; 0.44 mmol; 1.5 eq) were added. The reaction mixture was stirred at room temperature for 2 days. Ammonium chloride and ethyl acetate (20 mL) were added and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with saturated sodium chloride (3 x 15 mL), dried over sodium sulfate, filtered and concentrated to dryness. The crude was purified by preparative HPLC and the title compound 2-[l-(4- fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4- yl]-N-(5-methoxy-l,3-thiazol-2-yl)acetamide was obtained in 8% yield (12 mg) as a white powder. 1H-NMR (DMSO-d6): delta (ppm) 2.78 (m, 1H), 2.85 (m, 1H), 3.16 (d, 1H), 3.33 (m, 1H), 3.63 (m, 1H), 3.72 (s, 3H), 3.85 (s, 3H), 4.10 (m, 1H), 4.81 (m, 1H), 6.83 (m, 3H), 7.15 (d, 2H), 7.39 (m, 4H), 12.14 (s, 1H); MS (ESI+): m/z = 514.8 [M+H]+ .

Reference： [1]Patent: EP2664616,2013,A1 .Location in patent: Paragraph 0274-0275
[2]Patent: WO2013/171281,2013,A1 .Location in patent: Page/Page column 141-142

9
[ 124-41-4 ]
[ 61296-22-8 ]
[ 59019-85-1 ]

Yield	Reaction Conditions	Operation in experiment
38%	With methanol; potassium carbonate; at 20℃;	a) 5-Methoxy-1,3-thiazol-2-amine (I-45). [0272] Potassium carbonate (4.7 g; 34.4 mmol; 3 eq) and sodium methanoate (1.8 g; 34.4 mmol; 3 eq) were added to a solution of <strong>[61296-22-8]5-bromo-1,3-thiazol-2-amine hydrobromide</strong> (2.9 g; 11.5 mmol; 1 eq) in methanol (37 mL). The reaction mixture was stirred at room temperature overnight. The mixture was concentrated to dryness. The crude was purified on silica gel using ethyl acetate/ dichloromethane (80/20 to 100/0) as an eluent. The title compound 5-methoxy-1,3-thiazol-2-amine was obtained in 38% yield (564 mg) as a purple solid. 1H-NMR (CDCl3): delta (ppm) 3.82 (s, 3H), 4.48 (m, 2H), 6.41 (s, 1H).
38%	With methanol; potassium carbonate; at 20℃;	a) 5-Methoxy- 1 ,3-thiazol-2-amine (1-45) . K2C03, RT, overnight Potassium carbonate (4.7 g; 34.4 mmol; 3 eq) and sodium methanoate (1.8 g; 34.4 mmol; 3 eq) were added to a solution of 5-bromo-l,3-thiazol-2-amine hydrobromide (2.9 g; 11.5 mmol; 1 eq) in methanol (37 mL). The reaction mixture was stirred at room temperature overnight. The mixture was concentrated to dryness. The crude was purified on silica gel using ethyl acetate/dichloromethane (80/20 to 100/0) as an eluent. The title compound 5-methoxy-l,3-thiazol-2-amine was obtained in 38% yield (564 mg) as a purple solid. 1H-NMR (CDC13): delta (ppm) 3.82 (s, 3H), 4.48 (m, 2H), 6.41 (s, 1H).
	In methanol; at 0 - 20℃; for 1h;	To a solution of 5-bromo-l,3-tniazol-2-amine hydrobromide (26 g, 100 mmol) in methanol (100 mL) was added dropwise sodium methoxide (12 g, 222 mmol) in 40 mL methanol at 0 C. The resulting solution was stirred for 1 h at room temperature and the reaction was diluted with ethyl acetate. The solids were filtered out and the filtrate was concentrated in vacuo to afford 5-methoxy-l,3-thiazol-2- amine (6.5 g, crude) as a tan solid. LCMS (ESI): M+H+ = 131.0.

Reference： [1]Patent: EP2664616,2013,A1 .Location in patent: Paragraph 0272-0273
[2]Patent: WO2013/171281,2013,A1 .Location in patent: Page/Page column 141
[3]Patent: WO2015/52226,2015,A1 .Location in patent: Paragraph 0479

10
[ 22509-74-6 ]
[ 59019-85-1 ]
2-(5-methoxy-1,3-thiazol-2-yl)-2,3-dihydro-1H-isoindole-1,3-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
5 g	In acetonitrile; at 50℃;	To a solution of 5-methoxy-l,3-thiazol-2-amine (6.50 g, crude) in acetonitrile (100 mL) was added ethyl l,3-dioxo-2,3-dihydro-lH-isoindole-2-carboxylate (10.9 g, 49.9 mmol). The resulting solution was stirred overnight at 50 C and then concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with dichloromethane/petroleum ether (3/1) to afford 2-(5-methoxy- 1, 3-thiazol-2-yl)-2,3-dihydro-lH-isoindole-l,3-dione (5 g, 38%) as a light brown solid. LCMS (ESI): M+H+ = 261.0.

Reference： [1]Patent: WO2015/52226,2015,A1 .Location in patent: Paragraph 0480

11
2-bromo-1-(4-((tert-butyldimethylsilyl)oxy)-6-methoxybenzofuran-2-yl)-ethanone [ No CAS ]
[ 59019-85-1 ]
6-(4-((tert-Butyldimethylsilyl)oxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b]thiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	In tetrahydrofuran; at 60℃; for 18h;Inert atmosphere;	ompound 37b (1.8 g, 4.5 mmol) was dissolved in 25 mL of tetrahydrofuran under argon, and compound 2a (880 mg, 6.8 mmol) was added.The reaction was heated to 60 C for 18 hours. After the reaction has cooled to room temperature,The reaction solution was concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography using eluent system C.The title compound 37c (1.2 g, yield: 60%) was obtained.

Reference： [1]Patent: CN110218218,2019,A .Location in patent: Paragraph 0808; 0810; 0819-0821

12
2-bromo-1-(6-methoxy-4-((2-(4-methoxyphenyl)thiazol-4-yl)methoxy)benzofuran-2-yl)propan-1-one [ No CAS ]
[ 59019-85-1 ]
2-methoxy-6-(6-methoxy-4-((2-(4-methoxyphenyl)thiazol-4-yl)methoxy)benzofuran-2-yl)-5 -methylimidazo[2,1-b]thiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
31%	In isopropyl alcohol; at 80℃; for 24h;	Compound 39 (30 mg, 0 · 06 mmol) was dissolved in 5 mL of isopropanol.Compound 2a (13 mg, 0.1 mmol) was added.The reaction was heated to 80 C for 24 hours.After the reaction was cooled to room temperature, the reaction solution was concentrated under reduced pressure.The resulting residue was purified by silica gel column chromatography using eluent system A.The title compound 39 was obtained (13 mg, yield: 31%)

Reference： [1]Patent: CN110218218,2019,A .Location in patent: Paragraph 0849; 0851; 0865-0869

13
tert-butyl 4-(4-(((2-(2-bromoacetyl)-6-methoxybenzofuran-4-yl)oxy)methyl)thiazol-2-yl)piperazine-1-carboxylate [ No CAS ]
[ 59019-85-1 ]
tert-butyl 4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b]thiazol-6-yl)benzofuran-4-yl)oxy)methyl)tert-butylthiazol-2-yl)piperazine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
17%	In isopropyl alcohol; at 160℃; for 16h;	Compound 45d (60 mg, 0.1 mmol) was dissolved in 5 mL of isopropanol.Compound 2a (30 mg, 0.2 mmol) was added.The reaction was heated to 160 C for 16 hours.After the reaction was cooled to room temperature, the reaction solution was concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography using eluent system C.The title compound 45 (1 lmg, yield: 17%) was obtained.

Reference： [1]Patent: CN110218218,2019,A .Location in patent: Paragraph 0922; 0923; 0934-0937

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P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 59019-85-1 ] {[proInfo.proName]}

Quality Control of [ 59019-85-1 ]

Related Doc. of [ 59019-85-1 ]

Product Details of [ 59019-85-1 ]

Calculated chemistry of [ 59019-85-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 59019-85-1 ]

Application In Synthesis of [ 59019-85-1 ]

[ 59019-85-1 ] Synthesis Path-Downstream 1~13

Related Functional Groups of [ 59019-85-1 ]

Ethers

Amines

Related Parent Nucleus of [ 59019-85-1 ]

Thiazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 59019-85-1 ]

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[ 59019-85-1 ]