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Chemical Structure| 5904-62-1 Chemical Structure| 5904-62-1

Structure of 5904-62-1

Chemical Structure| 5904-62-1

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Product Details of [ 5904-62-1 ]

CAS No. :5904-62-1
Formula : C4H9NO
M.W : 87.12
SMILES Code : ON1CCCC1
MDL No. :MFCD00154179

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Application In Synthesis of [ 5904-62-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5904-62-1 ]

[ 5904-62-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5904-62-1 ]
  • [ 5467-57-2 ]
  • (R)-(2-Chloroquinolin-4-yl)(3-hydroxypyrrolidin-1-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; sodium hydrogencarbonate; triethylamine; In chloroform; Reference Example 104 (R)-(2-Chloroquinolin-4-yl)(3-hydroxypyrrolidin-1-yl)methanone A mixture of <strong>[5467-57-2]2-chloroquinoline-4-carboxylic acid</strong> (623 mg), thionyl chloride (2.19 mL), and chloroform (10 mL) was refluxed overnight, and the reaction mixture was concentrated. To the residue, triethylamine (502 muL) and chloroform (8 mL) were added, and the mixture was cooled to 0° C. A solution of (R)-pyrrolidinol in chloroform (2 mL) was added dropwise thereto, and the mixture was stirred at the same temperature as above for 1 hour. To the reaction mixture, water and a saturated aqueous solution of sodium bicarbonate were added, followed by extraction with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was washed with a dichloromethane-hexane (1:3) mixed solution to obtain the title compound (720 mg). 1H NMR (CDCl3, 400 MHz): delta (ppm) 8.04-8.09 (m, 1H), 7.82-7.86 (m, 1H), 7.75-7.81 (m, 1H), 7.58-7.63 (m, 1H), 7.37 (d, J=7.7 Hz, 1H), 4.43-4.70 (m, 1H), 3.79-3.98 (m, 2H), 3.10-3.50 (m, 2H), 1.94-2.20 (m, 2H) MS (ESI+) m/z: 277 [M+H]+
 

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